Acute Fatal Hemorrhage-Induced Activation of Lipid Peroxidation Processes and Cardiac Lesion

The time course of changes in myocardial lipid peroxidation processes was studied in an experiment on albino male rats that had experienced 4-minute clinical death. There was an alternation of periods of a significant increase (minute 90, hours 3—6, and days 1—3 and 14) and a decrease (days 7, 21, a...

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Main Authors: V. T. Dolgikh, F. I. Razgonov, L. G. Shikunova
Format: Article
Language:English
Published: Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia 2006-12-01
Series:Общая реаниматология
Subjects:
Online Access:https://www.reanimatology.com/rmt/article/view/1361
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author V. T. Dolgikh
F. I. Razgonov
L. G. Shikunova
author_facet V. T. Dolgikh
F. I. Razgonov
L. G. Shikunova
author_sort V. T. Dolgikh
collection DOAJ
description The time course of changes in myocardial lipid peroxidation processes was studied in an experiment on albino male rats that had experienced 4-minute clinical death. There was an alternation of periods of a significant increase (minute 90, hours 3—6, and days 1—3 and 14) and a decrease (days 7, 21, and 30) in the rate of lipoprotein processes and corresponding changes in the content of lipid hydroperoxides and Schiff s bases. Activation of lipid peroxidation processes occurred with deficiency of bioantioxidants and with inhibition of enzymes that made antiradical and antiperoxide protection of cardiomyocytes.acute fatal hemorrhage; resuscitation; heart; lipid peroxidation
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publishDate 2006-12-01
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spelling doaj.art-3f6c964f943d424e8908a1a796d6be3b2023-03-13T09:32:46ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102006-12-0126505410.15360/1813-9779-2006-6-50-541361Acute Fatal Hemorrhage-Induced Activation of Lipid Peroxidation Processes and Cardiac LesionV. T. Dolgikh0F. I. Razgonov1L. G. Shikunova2Омская государственная медицинская академия (кафедра патофизиологии, кафедра военной и экстремальной медицины)Омская государственная медицинская академия (кафедра патофизиологии, кафедра военной и экстремальной медицины)ГУ НИИ общей реаниматологии РАМН, МоскваThe time course of changes in myocardial lipid peroxidation processes was studied in an experiment on albino male rats that had experienced 4-minute clinical death. There was an alternation of periods of a significant increase (minute 90, hours 3—6, and days 1—3 and 14) and a decrease (days 7, 21, and 30) in the rate of lipoprotein processes and corresponding changes in the content of lipid hydroperoxides and Schiff s bases. Activation of lipid peroxidation processes occurred with deficiency of bioantioxidants and with inhibition of enzymes that made antiradical and antiperoxide protection of cardiomyocytes.acute fatal hemorrhage; resuscitation; heart; lipid peroxidationhttps://www.reanimatology.com/rmt/article/view/1361острая смертельная кровопотеряреанимациясердцеперекисное окисление липидов
spellingShingle V. T. Dolgikh
F. I. Razgonov
L. G. Shikunova
Acute Fatal Hemorrhage-Induced Activation of Lipid Peroxidation Processes and Cardiac Lesion
Общая реаниматология
острая смертельная кровопотеря
реанимация
сердце
перекисное окисление липидов
title Acute Fatal Hemorrhage-Induced Activation of Lipid Peroxidation Processes and Cardiac Lesion
title_full Acute Fatal Hemorrhage-Induced Activation of Lipid Peroxidation Processes and Cardiac Lesion
title_fullStr Acute Fatal Hemorrhage-Induced Activation of Lipid Peroxidation Processes and Cardiac Lesion
title_full_unstemmed Acute Fatal Hemorrhage-Induced Activation of Lipid Peroxidation Processes and Cardiac Lesion
title_short Acute Fatal Hemorrhage-Induced Activation of Lipid Peroxidation Processes and Cardiac Lesion
title_sort acute fatal hemorrhage induced activation of lipid peroxidation processes and cardiac lesion
topic острая смертельная кровопотеря
реанимация
сердце
перекисное окисление липидов
url https://www.reanimatology.com/rmt/article/view/1361
work_keys_str_mv AT vtdolgikh acutefatalhemorrhageinducedactivationoflipidperoxidationprocessesandcardiaclesion
AT firazgonov acutefatalhemorrhageinducedactivationoflipidperoxidationprocessesandcardiaclesion
AT lgshikunova acutefatalhemorrhageinducedactivationoflipidperoxidationprocessesandcardiaclesion