Bridging the Nanoscopy-Immunology Gap
Bridging the gap between traditional immunology and nanoscale biophysics has proved more difficult than originally thought. For cell biology applications however, super-resolution microscopy has already facilitated considerable advances. From neuronal segmentation to nuclear pores and 3D focal adhes...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-01-01
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| Series: | Frontiers in Physics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphy.2018.00157/full |
| _version_ | 1818194619399143424 |
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| author | Michael Shannon Dylan M. Owen |
| author_facet | Michael Shannon Dylan M. Owen |
| author_sort | Michael Shannon |
| collection | DOAJ |
| description | Bridging the gap between traditional immunology and nanoscale biophysics has proved more difficult than originally thought. For cell biology applications however, super-resolution microscopy has already facilitated considerable advances. From neuronal segmentation to nuclear pores and 3D focal adhesion structure—nanoscopy has begun to illuminate links between nanoscale organization and function. With immunology, the explanation must go further, relating nanoscale biophysical phenomena to the manifestation of specific diseases, or the altered activity of specific immune cell types in a bodily compartment. What follows is a summary of how nanoscopy has elucidated single cell immunological function, and what might be achieved in the future to link quantifiable, nanoscale, biophysical phenomena with cell and whole tissue functionality. We explore where the gaps in our understanding occur, and how they might be addressed. |
| first_indexed | 2024-12-12T01:05:10Z |
| format | Article |
| id | doaj.art-3f6dab39ed0b4cbd81940b141e0befb0 |
| institution | Directory Open Access Journal |
| issn | 2296-424X |
| language | English |
| last_indexed | 2024-12-12T01:05:10Z |
| publishDate | 2019-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physics |
| spelling | doaj.art-3f6dab39ed0b4cbd81940b141e0befb02022-12-22T00:43:35ZengFrontiers Media S.A.Frontiers in Physics2296-424X2019-01-01610.3389/fphy.2018.00157426629Bridging the Nanoscopy-Immunology GapMichael ShannonDylan M. OwenBridging the gap between traditional immunology and nanoscale biophysics has proved more difficult than originally thought. For cell biology applications however, super-resolution microscopy has already facilitated considerable advances. From neuronal segmentation to nuclear pores and 3D focal adhesion structure—nanoscopy has begun to illuminate links between nanoscale organization and function. With immunology, the explanation must go further, relating nanoscale biophysical phenomena to the manifestation of specific diseases, or the altered activity of specific immune cell types in a bodily compartment. What follows is a summary of how nanoscopy has elucidated single cell immunological function, and what might be achieved in the future to link quantifiable, nanoscale, biophysical phenomena with cell and whole tissue functionality. We explore where the gaps in our understanding occur, and how they might be addressed.https://www.frontiersin.org/article/10.3389/fphy.2018.00157/fullT cellsimmunologySMLMnanoscopysuper-resolution |
| spellingShingle | Michael Shannon Dylan M. Owen Bridging the Nanoscopy-Immunology Gap Frontiers in Physics T cells immunology SMLM nanoscopy super-resolution |
| title | Bridging the Nanoscopy-Immunology Gap |
| title_full | Bridging the Nanoscopy-Immunology Gap |
| title_fullStr | Bridging the Nanoscopy-Immunology Gap |
| title_full_unstemmed | Bridging the Nanoscopy-Immunology Gap |
| title_short | Bridging the Nanoscopy-Immunology Gap |
| title_sort | bridging the nanoscopy immunology gap |
| topic | T cells immunology SMLM nanoscopy super-resolution |
| url | https://www.frontiersin.org/article/10.3389/fphy.2018.00157/full |
| work_keys_str_mv | AT michaelshannon bridgingthenanoscopyimmunologygap AT dylanmowen bridgingthenanoscopyimmunologygap |