Acute toxicity investigation of polysaccharide extracts of Lentinus polychrous in rats
Lentinus polychrous (LP) is an edible mushroom that has been increasingly used as a food or a nutritional supplement. The present study investigated acute toxicity of LP in rats. Male and female rats (n = 10/group) were administered a single-dose of 50, 500, and 2,500 mg/kg of polysaccharide extra...
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| Format: | Article |
| Language: | English |
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Prince of Songkla University
2015-08-01
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| Series: | Songklanakarin Journal of Science and Technology (SJST) |
| Subjects: | |
| Online Access: | http://rdo.psu.ac.th/sjstweb/journal/37-4/37-4-8.pdf |
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| author | Catheleeya Mekjaruskul Niramai Fangkrathok Bungorn Sripanidkulchai |
| author_facet | Catheleeya Mekjaruskul Niramai Fangkrathok Bungorn Sripanidkulchai |
| author_sort | Catheleeya Mekjaruskul |
| collection | DOAJ |
| description | Lentinus polychrous (LP) is an edible mushroom that has been increasingly used as a food or a nutritional supplement.
The present study investigated acute toxicity of LP in rats. Male and female rats (n = 10/group) were administered
a single-dose of 50, 500, and 2,500 mg/kg of polysaccharide extract from either LP fruiting body (PSF) or LP mycelium (PSM).
Two control groups, untreated and vehicle (distilled water) administered were included. Body weight, food and water intake,
general signs, and mortality were observed for 14 days. Blood samples and organ weights were evaluated at day 14. All
treatments caused no effects on food and water consumption, body weight, general signs, gross pathology of organs, organ
weight, hematological parameters, or changes in biochemical parameters. We conclude that the NOAEL (no observedadverse-effect level) dose is greater than 2,500 mg/kg. |
| first_indexed | 2024-04-13T05:43:54Z |
| format | Article |
| id | doaj.art-3f6e36f6102645f2ba321e975a85a2e6 |
| institution | Directory Open Access Journal |
| issn | 0125-3395 |
| language | English |
| last_indexed | 2024-04-13T05:43:54Z |
| publishDate | 2015-08-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Songklanakarin Journal of Science and Technology (SJST) |
| spelling | doaj.art-3f6e36f6102645f2ba321e975a85a2e62022-12-22T03:00:00ZengPrince of Songkla UniversitySongklanakarin Journal of Science and Technology (SJST)0125-33952015-08-01374433439Acute toxicity investigation of polysaccharide extracts of Lentinus polychrous in ratsCatheleeya Mekjaruskul0Niramai Fangkrathok1Bungorn Sripanidkulchai2Faculty of Pharmacy, Mahasarakham University, Kantharawichai, Maha Sarakham, 44150 Thailand.Faculty of Agricultural Technology, Burapha University Sakaeo Campus, Watthana Nakhon, Sa Kaeo, 27160 Thailand.Center for Research and Development of Herbal Health Products, Khon Kaen University, Mueang, Khon Kaen, 40002 Thailand.Lentinus polychrous (LP) is an edible mushroom that has been increasingly used as a food or a nutritional supplement. The present study investigated acute toxicity of LP in rats. Male and female rats (n = 10/group) were administered a single-dose of 50, 500, and 2,500 mg/kg of polysaccharide extract from either LP fruiting body (PSF) or LP mycelium (PSM). Two control groups, untreated and vehicle (distilled water) administered were included. Body weight, food and water intake, general signs, and mortality were observed for 14 days. Blood samples and organ weights were evaluated at day 14. All treatments caused no effects on food and water consumption, body weight, general signs, gross pathology of organs, organ weight, hematological parameters, or changes in biochemical parameters. We conclude that the NOAEL (no observedadverse-effect level) dose is greater than 2,500 mg/kg.http://rdo.psu.ac.th/sjstweb/journal/37-4/37-4-8.pdfLentinus polychrousmushroommyceliafruiting bodyacute toxicity |
| spellingShingle | Catheleeya Mekjaruskul Niramai Fangkrathok Bungorn Sripanidkulchai Acute toxicity investigation of polysaccharide extracts of Lentinus polychrous in rats Songklanakarin Journal of Science and Technology (SJST) Lentinus polychrous mushroom mycelia fruiting body acute toxicity |
| title | Acute toxicity investigation of polysaccharide extracts of Lentinus polychrous in rats |
| title_full | Acute toxicity investigation of polysaccharide extracts of Lentinus polychrous in rats |
| title_fullStr | Acute toxicity investigation of polysaccharide extracts of Lentinus polychrous in rats |
| title_full_unstemmed | Acute toxicity investigation of polysaccharide extracts of Lentinus polychrous in rats |
| title_short | Acute toxicity investigation of polysaccharide extracts of Lentinus polychrous in rats |
| title_sort | acute toxicity investigation of polysaccharide extracts of lentinus polychrous in rats |
| topic | Lentinus polychrous mushroom mycelia fruiting body acute toxicity |
| url | http://rdo.psu.ac.th/sjstweb/journal/37-4/37-4-8.pdf |
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