Changing the course of schizophrenia - predictors of treatment outcome revisited
Multiple factors play a role in determining the outcome of schizophrenia. However, the role of these factors is poorly understood, and research findings so far have been inconclusive and sometimes contradictory. Various demographic and baseline clinical factors have been reported to be associated wi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AOSIS
2007-02-01
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| Series: | South African Journal of Psychiatry |
| Online Access: | http://www.sajp.org.za/index.php/sajp/article/view/4 |
| _version_ | 1811291440294133760 |
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| author | R Emsley P Oosthuizen D Niehaus L Koen B Chiliza |
| author_facet | R Emsley P Oosthuizen D Niehaus L Koen B Chiliza |
| author_sort | R Emsley |
| collection | DOAJ |
| description | Multiple factors play a role in determining the outcome of schizophrenia. However, the role of these factors is poorly understood, and research findings so far have been inconclusive and sometimes contradictory. Various demographic and baseline clinical factors have been reported to be associated with treatment outcome. Also, early symptom reduction after initiation of antipsychotic therapy is closely related to later treatment response. However, associations as such do not necessarily imply predictive value, and none of these factors can be regarded as clinically useful in predicting treatment outcome. This article discusses selected aspects of treatment outcome and its prediction in schizophrenia, focusing particularly on early treatment response, ethnicity, neurological soft signs, and the predictive value of a discriminant functional analysis model utilising a combination of putative predictors. Such a model holds promise, and it is to be hoped that future refinements will lead to a clinically useful model for predicting outcome. |
| first_indexed | 2024-04-13T04:29:25Z |
| format | Article |
| id | doaj.art-3f6e4e95f48747659cf31f62cf2d5f01 |
| institution | Directory Open Access Journal |
| issn | 1608-9685 2078-6786 |
| language | English |
| last_indexed | 2024-04-13T04:29:25Z |
| publishDate | 2007-02-01 |
| publisher | AOSIS |
| record_format | Article |
| series | South African Journal of Psychiatry |
| spelling | doaj.art-3f6e4e95f48747659cf31f62cf2d5f012022-12-22T03:02:22ZengAOSISSouth African Journal of Psychiatry1608-96852078-67862007-02-0113110.4102/sajpsychiatry.v13i1.4185Changing the course of schizophrenia - predictors of treatment outcome revisitedR Emsley0P Oosthuizen1D Niehaus2L Koen3B Chiliza4Department of Psychiatry, Stellenbosch University, Tygerberg, Western CapeDepartment of Psychiatry, Stellenbosch University, Tygerberg, Western CapeDepartment of Psychiatry, Stellenbosch University, Tygerberg, Western CapeDepartment of Psychiatry, Stellenbosch University, Tygerberg, Western CapeDepartment of Psychiatry, Stellenbosch University, Tygerberg, Western CapeMultiple factors play a role in determining the outcome of schizophrenia. However, the role of these factors is poorly understood, and research findings so far have been inconclusive and sometimes contradictory. Various demographic and baseline clinical factors have been reported to be associated with treatment outcome. Also, early symptom reduction after initiation of antipsychotic therapy is closely related to later treatment response. However, associations as such do not necessarily imply predictive value, and none of these factors can be regarded as clinically useful in predicting treatment outcome. This article discusses selected aspects of treatment outcome and its prediction in schizophrenia, focusing particularly on early treatment response, ethnicity, neurological soft signs, and the predictive value of a discriminant functional analysis model utilising a combination of putative predictors. Such a model holds promise, and it is to be hoped that future refinements will lead to a clinically useful model for predicting outcome.http://www.sajp.org.za/index.php/sajp/article/view/4 |
| spellingShingle | R Emsley P Oosthuizen D Niehaus L Koen B Chiliza Changing the course of schizophrenia - predictors of treatment outcome revisited South African Journal of Psychiatry |
| title | Changing the course of schizophrenia - predictors of treatment outcome revisited |
| title_full | Changing the course of schizophrenia - predictors of treatment outcome revisited |
| title_fullStr | Changing the course of schizophrenia - predictors of treatment outcome revisited |
| title_full_unstemmed | Changing the course of schizophrenia - predictors of treatment outcome revisited |
| title_short | Changing the course of schizophrenia - predictors of treatment outcome revisited |
| title_sort | changing the course of schizophrenia predictors of treatment outcome revisited |
| url | http://www.sajp.org.za/index.php/sajp/article/view/4 |
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