Association between anticholinergic burden and dementia in UK Biobank
Abstract Background Previous studies on the relationship between anticholinergic drugs and dementia have reported heterogeneous results. This variability could be due to different anticholinergic scales and differential effects of distinct classes of drugs. Methods Using Cox proportional hazards mod...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/trc2.12290 |
| _version_ | 1797949052445261824 |
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| author | Jure Mur Tom C. Russ Simon R. Cox Riccardo E. Marioni Graciela Muniz‐Terrera |
| author_facet | Jure Mur Tom C. Russ Simon R. Cox Riccardo E. Marioni Graciela Muniz‐Terrera |
| author_sort | Jure Mur |
| collection | DOAJ |
| description | Abstract Background Previous studies on the relationship between anticholinergic drugs and dementia have reported heterogeneous results. This variability could be due to different anticholinergic scales and differential effects of distinct classes of drugs. Methods Using Cox proportional hazards models, we computed the association between annual anticholinergic burden (AChB) and the risk of dementia in UK Biobank with linked general practitioner prescription records between the years 2000 and 2015 (n = 171,775). Results AChB according to most anticholinergic scales (standardized odds ratio range: 1.027–1.125) and the slope of the AChB trajectory (hazard ratio = 1.094; 95% confidence interval: 1.068–1.119) were predictive of dementia. However, the association between AChB and dementia held only for some classes of drugs, especially antidepressants, antiepileptics, and antidiuretics. Discussion The heterogeneity in previous findings may partially be due to different effects for different classes of drugs. Future studies should establish differences in more detail and further examine the practicality of a general measure of AChB relating to the risk of dementia. |
| first_indexed | 2024-04-10T21:53:14Z |
| format | Article |
| id | doaj.art-3f6f8ca98f194a85879d64232fdb9790 |
| institution | Directory Open Access Journal |
| issn | 2352-8737 |
| language | English |
| last_indexed | 2024-04-10T21:53:14Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj.art-3f6f8ca98f194a85879d64232fdb97902023-01-18T11:41:03ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372022-01-0181n/an/a10.1002/trc2.12290Association between anticholinergic burden and dementia in UK BiobankJure Mur0Tom C. Russ1Simon R. Cox2Riccardo E. Marioni3Graciela Muniz‐Terrera4Lothian Birth Cohorts Group Department of Psychology University of Edinburgh Edinburgh UKAlzheimer Scotland Dementia Research Centre University of Edinburgh Edinburgh UKLothian Birth Cohorts Group Department of Psychology University of Edinburgh Edinburgh UKCentre for Genomic and Experimental Medicine Institute of Genetics and Cancer University of Edinburgh Edinburgh UKEdinburgh Dementia Prevention University of Edinburgh Edinburgh UKAbstract Background Previous studies on the relationship between anticholinergic drugs and dementia have reported heterogeneous results. This variability could be due to different anticholinergic scales and differential effects of distinct classes of drugs. Methods Using Cox proportional hazards models, we computed the association between annual anticholinergic burden (AChB) and the risk of dementia in UK Biobank with linked general practitioner prescription records between the years 2000 and 2015 (n = 171,775). Results AChB according to most anticholinergic scales (standardized odds ratio range: 1.027–1.125) and the slope of the AChB trajectory (hazard ratio = 1.094; 95% confidence interval: 1.068–1.119) were predictive of dementia. However, the association between AChB and dementia held only for some classes of drugs, especially antidepressants, antiepileptics, and antidiuretics. Discussion The heterogeneity in previous findings may partially be due to different effects for different classes of drugs. Future studies should establish differences in more detail and further examine the practicality of a general measure of AChB relating to the risk of dementia.https://doi.org/10.1002/trc2.12290anticholinergic drugscohort studydementiaprescriptions drugsprimary care |
| spellingShingle | Jure Mur Tom C. Russ Simon R. Cox Riccardo E. Marioni Graciela Muniz‐Terrera Association between anticholinergic burden and dementia in UK Biobank Alzheimer’s & Dementia: Translational Research & Clinical Interventions anticholinergic drugs cohort study dementia prescriptions drugs primary care |
| title | Association between anticholinergic burden and dementia in UK Biobank |
| title_full | Association between anticholinergic burden and dementia in UK Biobank |
| title_fullStr | Association between anticholinergic burden and dementia in UK Biobank |
| title_full_unstemmed | Association between anticholinergic burden and dementia in UK Biobank |
| title_short | Association between anticholinergic burden and dementia in UK Biobank |
| title_sort | association between anticholinergic burden and dementia in uk biobank |
| topic | anticholinergic drugs cohort study dementia prescriptions drugs primary care |
| url | https://doi.org/10.1002/trc2.12290 |
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