Pseudoneutropenia from cold agglutinin leucoagglutination

Pseudoneutropenia or low leucocyte count secondary to leucoagglutination is caused by ethylene diamine tetra acetic acid (EDTA) or cold agglutinins and is seen in benign and malignant disorders. We report a 34-year-old lady who was admitted with fever, vomiting, respiratory distress and productive...

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Main Authors: Momin M, Yashovardhan A, Quadri A, Aluri A, Ingle A, Satyanarayana M, Agarwal R
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2015-01-01
Series:Journal of Clinical and Scientific Research
Subjects:
Online Access:http://svimstpt.ap.nic.in/jcsr/jan-mar15_files/5cr15.pdf
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author Momin M
Yashovardhan A
Quadri A
Aluri A
Ingle A
Satyanarayana M
Agarwal R
author_facet Momin M
Yashovardhan A
Quadri A
Aluri A
Ingle A
Satyanarayana M
Agarwal R
author_sort Momin M
collection DOAJ
description Pseudoneutropenia or low leucocyte count secondary to leucoagglutination is caused by ethylene diamine tetra acetic acid (EDTA) or cold agglutinins and is seen in benign and malignant disorders. We report a 34-year-old lady who was admitted with fever, vomiting, respiratory distress and productive cough. Complete blood count (CBC) at initial presentation revealed low haemoglobin (11.6 g/dL), total leucocyte count (TLC) (5900/mm3 ) with 50% polymorphs. Peripheral blood smear showed leucocytes in clusters. Another sample was asked for in citrate anticoagulant which showed a TLC of 5900/mm3 with 50% polymorphs and evidence of auto agglutination. Another collected in a prewarmed ethylene diamine tetra acetic acid (EDTA) tube, CBC showed a TLC of 9800/mm3 with 39% neutrophils suggestive of pseudoneutropenia due to cold agglutinins.
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spelling doaj.art-3f70fca9221f4f73af75f1ea6b296be92022-12-22T04:14:28ZengWolters Kluwer Medknow PublicationsJournal of Clinical and Scientific Research2277-57062277-83572015-01-01415860http://dx.doi.org/10.15380/2277-5706.JCSR.14.016Pseudoneutropenia from cold agglutinin leucoagglutinationMomin M0Yashovardhan A1Quadri A2Aluri A3Ingle A4Satyanarayana M5Agarwal R6Yashoda Hospitals, HyderabadYashoda Hospitals, HyderabadYashoda Hospitals, HyderabadYashoda Hospitals, HyderabadYashoda Hospitals, HyderabadYashoda Hospitals, HyderabadYashoda Hospitals, HyderabadPseudoneutropenia or low leucocyte count secondary to leucoagglutination is caused by ethylene diamine tetra acetic acid (EDTA) or cold agglutinins and is seen in benign and malignant disorders. We report a 34-year-old lady who was admitted with fever, vomiting, respiratory distress and productive cough. Complete blood count (CBC) at initial presentation revealed low haemoglobin (11.6 g/dL), total leucocyte count (TLC) (5900/mm3 ) with 50% polymorphs. Peripheral blood smear showed leucocytes in clusters. Another sample was asked for in citrate anticoagulant which showed a TLC of 5900/mm3 with 50% polymorphs and evidence of auto agglutination. Another collected in a prewarmed ethylene diamine tetra acetic acid (EDTA) tube, CBC showed a TLC of 9800/mm3 with 39% neutrophils suggestive of pseudoneutropenia due to cold agglutinins.http://svimstpt.ap.nic.in/jcsr/jan-mar15_files/5cr15.pdfLeucoagglutinationPseudoneutropeniaCold agglutinins
spellingShingle Momin M
Yashovardhan A
Quadri A
Aluri A
Ingle A
Satyanarayana M
Agarwal R
Pseudoneutropenia from cold agglutinin leucoagglutination
Journal of Clinical and Scientific Research
Leucoagglutination
Pseudoneutropenia
Cold agglutinins
title Pseudoneutropenia from cold agglutinin leucoagglutination
title_full Pseudoneutropenia from cold agglutinin leucoagglutination
title_fullStr Pseudoneutropenia from cold agglutinin leucoagglutination
title_full_unstemmed Pseudoneutropenia from cold agglutinin leucoagglutination
title_short Pseudoneutropenia from cold agglutinin leucoagglutination
title_sort pseudoneutropenia from cold agglutinin leucoagglutination
topic Leucoagglutination
Pseudoneutropenia
Cold agglutinins
url http://svimstpt.ap.nic.in/jcsr/jan-mar15_files/5cr15.pdf
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