Deformability of Erythrocytes and Oxidative Damage in Alzheimer Disease
Purpose: A lowered cerebral perfusion as a consequence of hemodynamic microcirculatory insufficiency is one of the factors underlying in Alzheimer's disease, which is a neurodegenerative disorder leading to progressive cognitive impairment. Erythrocyte deformability is one of the major factors...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cukurova University
2012-04-01
|
| Series: | Çukurova Üniversitesi Tıp Fakültesi Dergisi |
| Subjects: | |
| Online Access: | http://www.scopemed.org/fulltextpdf.php?mno=21427 |
| _version_ | 1797923241028747264 |
|---|---|
| author | Mukerrem Betul Yerer Sami Aydogan Emel Koseoglu Recep Bastug |
| author_facet | Mukerrem Betul Yerer Sami Aydogan Emel Koseoglu Recep Bastug |
| author_sort | Mukerrem Betul Yerer |
| collection | DOAJ |
| description | Purpose: A lowered cerebral perfusion as a consequence of hemodynamic microcirculatory insufficiency is one of the factors underlying in Alzheimer's disease, which is a neurodegenerative disorder leading to progressive cognitive impairment. Erythrocyte deformability is one of the major factors affecting the microcirculatory hemodynamics which is closely related to the oxidative damage. The aim of this study is to investigate the relationship between the erythrocyte deformability, nitric oxide levels and oxidative stress in Alzheimer's disease. Methods: The blood samples of 30 elderly people in three groups consisting of healthy control and different severities of the disease (low and severe) were used. Then the erythrocytes were isolated and the deformability of erythrocytes was determined by Rheodyne SSD evaluating the elongation indexes of the erythrocytes under different shear stress. The catalase, glutathione peroxidase and plasma nitric oxide levels were measured spectrophotometric ally. Results: The plasma nitric oxide levels, catalase activities were found significantly higher and glutathione peroxidase activity was significantly lower in severe Alzheimer's disease patients compared to the control group. However, the deformability of erythrocytes was not significantly affected from these alterations. Conclusion: the oxidant-antioxidant status is dramatically changed in Alzheimer's disease patients with the severity of the disease and similar alterations were seen in the nitric oxide levels without any significant change in erythrocyte deformability. [Cukurova Med J 2012; 37(2.000): 65-75] |
| first_indexed | 2024-04-10T14:43:29Z |
| format | Article |
| id | doaj.art-3f731b59c9b348de93d5591af46c6e15 |
| institution | Directory Open Access Journal |
| issn | 0250-5150 |
| language | English |
| last_indexed | 2024-04-10T14:43:29Z |
| publishDate | 2012-04-01 |
| publisher | Cukurova University |
| record_format | Article |
| series | Çukurova Üniversitesi Tıp Fakültesi Dergisi |
| spelling | doaj.art-3f731b59c9b348de93d5591af46c6e152023-02-15T16:08:02ZengCukurova UniversityÇukurova Üniversitesi Tıp Fakültesi Dergisi0250-51502012-04-013726575Deformability of Erythrocytes and Oxidative Damage in Alzheimer DiseaseMukerrem Betul YererSami AydoganEmel KoseogluRecep BastugPurpose: A lowered cerebral perfusion as a consequence of hemodynamic microcirculatory insufficiency is one of the factors underlying in Alzheimer's disease, which is a neurodegenerative disorder leading to progressive cognitive impairment. Erythrocyte deformability is one of the major factors affecting the microcirculatory hemodynamics which is closely related to the oxidative damage. The aim of this study is to investigate the relationship between the erythrocyte deformability, nitric oxide levels and oxidative stress in Alzheimer's disease. Methods: The blood samples of 30 elderly people in three groups consisting of healthy control and different severities of the disease (low and severe) were used. Then the erythrocytes were isolated and the deformability of erythrocytes was determined by Rheodyne SSD evaluating the elongation indexes of the erythrocytes under different shear stress. The catalase, glutathione peroxidase and plasma nitric oxide levels were measured spectrophotometric ally. Results: The plasma nitric oxide levels, catalase activities were found significantly higher and glutathione peroxidase activity was significantly lower in severe Alzheimer's disease patients compared to the control group. However, the deformability of erythrocytes was not significantly affected from these alterations. Conclusion: the oxidant-antioxidant status is dramatically changed in Alzheimer's disease patients with the severity of the disease and similar alterations were seen in the nitric oxide levels without any significant change in erythrocyte deformability. [Cukurova Med J 2012; 37(2.000): 65-75]http://www.scopemed.org/fulltextpdf.php?mno=21427Alzheimer ’s diseaseerythrocyte deformabilitynitric oxideantioxidant enzymes |
| spellingShingle | Mukerrem Betul Yerer Sami Aydogan Emel Koseoglu Recep Bastug Deformability of Erythrocytes and Oxidative Damage in Alzheimer Disease Çukurova Üniversitesi Tıp Fakültesi Dergisi Alzheimer ’s disease erythrocyte deformability nitric oxide antioxidant enzymes |
| title | Deformability of Erythrocytes and Oxidative Damage in Alzheimer Disease |
| title_full | Deformability of Erythrocytes and Oxidative Damage in Alzheimer Disease |
| title_fullStr | Deformability of Erythrocytes and Oxidative Damage in Alzheimer Disease |
| title_full_unstemmed | Deformability of Erythrocytes and Oxidative Damage in Alzheimer Disease |
| title_short | Deformability of Erythrocytes and Oxidative Damage in Alzheimer Disease |
| title_sort | deformability of erythrocytes and oxidative damage in alzheimer disease |
| topic | Alzheimer ’s disease erythrocyte deformability nitric oxide antioxidant enzymes |
| url | http://www.scopemed.org/fulltextpdf.php?mno=21427 |
| work_keys_str_mv | AT mukerrembetulyerer deformabilityoferythrocytesandoxidativedamageinalzheimerdisease AT samiaydogan deformabilityoferythrocytesandoxidativedamageinalzheimerdisease AT emelkoseoglu deformabilityoferythrocytesandoxidativedamageinalzheimerdisease AT recepbastug deformabilityoferythrocytesandoxidativedamageinalzheimerdisease |