Patent ductus arteriosus treatment in preterm neonates, which is the drug of choice paracetamol vs ibuprofen?
Background Patent ductus arteriosus (PDA) is one of the most prevalent problems in preterm infants. Although ibuprofen represents one of the choices for the closure of PDA, this treatment can cause severe gastrointestinal and adverse renal effects and worsen platelet function. Effective therapy for...
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| Format: | Article |
| Language: | English |
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General Organization of Teaching Hospitals and Institutes
2020-01-01
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| Series: | Journal of Medicine in Scientific Research |
| Subjects: | |
| Online Access: | http://www.jmsr.eg.net/article.asp?issn=2537-091X;year=2020;volume=3;issue=2;spage=108;epage=111;aulast=Abd |
| _version_ | 1797226411525668864 |
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| author | Reham S Abd Al Hamid |
| author_facet | Reham S Abd Al Hamid |
| author_sort | Reham S Abd Al Hamid |
| collection | DOAJ |
| description | Background
Patent ductus arteriosus (PDA) is one of the most prevalent problems in preterm infants. Although ibuprofen represents one of the choices for the closure of PDA, this treatment can cause severe gastrointestinal and adverse renal effects and worsen platelet function. Effective therapy for PDA had been suggested as paracetamol.
Aim
Our study is aiming to compare the efficacy and safety of paracetamol and ibuprofen.
Patients and methods
A prospective observational, single-center study was performed from December 2016 until August 2017, at ElGalaa Teaching Hospital in Cairo. In this study we included neonates with a gestational age of 28–36 weeks, diagnosed with a significant hemodynamically PDA using clinical and ultrasonographic cardiac evaluation. The pediatric cardiologist performed an echocardiographic examination before the start of the treatment and after seven days.
Results
We found that paracetamol had good efficacy on PDA in preterm infants, and the closure rate of paracetamol was comparable to that of ibuprofen.
Conclusion
Paracetamol may confer comparable treatment efficacy for the closure of PDA to ibuprofen, although paracetamol is associated with lower risk of adverse events. |
| first_indexed | 2024-04-24T14:24:29Z |
| format | Article |
| id | doaj.art-3f74c80407684b639e0164952558a3d2 |
| institution | Directory Open Access Journal |
| issn | 2537-091X 2537-0928 |
| language | English |
| last_indexed | 2024-04-24T14:24:29Z |
| publishDate | 2020-01-01 |
| publisher | General Organization of Teaching Hospitals and Institutes |
| record_format | Article |
| series | Journal of Medicine in Scientific Research |
| spelling | doaj.art-3f74c80407684b639e0164952558a3d22024-04-03T05:22:05ZengGeneral Organization of Teaching Hospitals and InstitutesJournal of Medicine in Scientific Research2537-091X2537-09282020-01-013210811110.4103/JMISR.JMISR_56_18Patent ductus arteriosus treatment in preterm neonates, which is the drug of choice paracetamol vs ibuprofen?Reham S Abd Al HamidBackground Patent ductus arteriosus (PDA) is one of the most prevalent problems in preterm infants. Although ibuprofen represents one of the choices for the closure of PDA, this treatment can cause severe gastrointestinal and adverse renal effects and worsen platelet function. Effective therapy for PDA had been suggested as paracetamol. Aim Our study is aiming to compare the efficacy and safety of paracetamol and ibuprofen. Patients and methods A prospective observational, single-center study was performed from December 2016 until August 2017, at ElGalaa Teaching Hospital in Cairo. In this study we included neonates with a gestational age of 28–36 weeks, diagnosed with a significant hemodynamically PDA using clinical and ultrasonographic cardiac evaluation. The pediatric cardiologist performed an echocardiographic examination before the start of the treatment and after seven days. Results We found that paracetamol had good efficacy on PDA in preterm infants, and the closure rate of paracetamol was comparable to that of ibuprofen. Conclusion Paracetamol may confer comparable treatment efficacy for the closure of PDA to ibuprofen, although paracetamol is associated with lower risk of adverse events.http://www.jmsr.eg.net/article.asp?issn=2537-091X;year=2020;volume=3;issue=2;spage=108;epage=111;aulast=Abdechocardiographyibuprofenparacetamolpatent ductus arteriosus |
| spellingShingle | Reham S Abd Al Hamid Patent ductus arteriosus treatment in preterm neonates, which is the drug of choice paracetamol vs ibuprofen? Journal of Medicine in Scientific Research echocardiography ibuprofen paracetamol patent ductus arteriosus |
| title | Patent ductus arteriosus treatment in preterm neonates, which is the drug of choice paracetamol vs ibuprofen? |
| title_full | Patent ductus arteriosus treatment in preterm neonates, which is the drug of choice paracetamol vs ibuprofen? |
| title_fullStr | Patent ductus arteriosus treatment in preterm neonates, which is the drug of choice paracetamol vs ibuprofen? |
| title_full_unstemmed | Patent ductus arteriosus treatment in preterm neonates, which is the drug of choice paracetamol vs ibuprofen? |
| title_short | Patent ductus arteriosus treatment in preterm neonates, which is the drug of choice paracetamol vs ibuprofen? |
| title_sort | patent ductus arteriosus treatment in preterm neonates which is the drug of choice paracetamol vs ibuprofen |
| topic | echocardiography ibuprofen paracetamol patent ductus arteriosus |
| url | http://www.jmsr.eg.net/article.asp?issn=2537-091X;year=2020;volume=3;issue=2;spage=108;epage=111;aulast=Abd |
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