Metagenomic and metabolomic analyses reveal synergistic effects of fecal microbiota transplantation and anti-PD-1 therapy on treating colorectal cancer

Metagenomic and metabolomic analyses reveal synergistic effects of fecal microbiota transplantation and anti-PD-1 therapy on treating colorectal cancer

Anti-PD-1 immunotherapy has saved numerous lives of cancer patients; however, it only exerts efficacy in 10-15% of patients with colorectal cancer. Fecal microbiota transplantation (FMT) is a potential approach to improving the efficacy of anti-PD-1 therapy, whereas the detailed mechanisms and the a...

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Bibliographic Details
Main Authors: Jiayuan Huang, Xing Zheng, Wanying Kang, Huaijie Hao, Yudan Mao, Hua Zhang, Yuan Chen, Yan Tan, Yulong He, Wenjing Zhao, Yiming Yin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
fecal microbiota transplantation
anti-PD-1 therapy
immunotherapy
colorectal cancer
Bacteroides
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.874922/full

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