The efficacy of combined treatment of secondary hyperthyroidism in pre-dialysis chronic kidney disease patients
Background. It is well known that chronic kidney disease (CKD) patients develop mineral and bone disturbances which lead to the development of renal osteodystrophy and its complications. Secondary hyperthyroidism is the main reason for the development of mineral and bone disoders in these patients...
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| Format: | Article |
| Language: | English |
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Zaslavsky O.Yu.
2023-03-01
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| Series: | Bolʹ, Sustavy, Pozvonočnik |
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| Online Access: | https://pjs.zaslavsky.com.ua/index.php/journal/article/view/356 |
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| author | L.P. Martynyuk O.I. Shershun T.L. Malska |
| author_facet | L.P. Martynyuk O.I. Shershun T.L. Malska |
| author_sort | L.P. Martynyuk |
| collection | DOAJ |
| description | Background. It is well known that chronic kidney disease (CKD) patients develop mineral and bone disturbances which lead to the development of renal osteodystrophy and its complications. Secondary hyperthyroidism is the main reason for the development of mineral and bone disoders in these patients. The purpose of the study was to evaluate the efficacy of combined therapy with Alfacalcidol and Quercetin in the treatment of secondary hyperthyroidism in pre-dialysis CKD patients. Materials and methods. 61 patients with CKD 3 and 4 stages aged 20–78 years were included in the study. Patients were divided into 2 groups: 35 patients received combined treatment with Alfacalcidol and Quercetin granules, and 26 patients received standard treatment with calcium carbonate. Indices of calcium, phosphorus, magnesium, and alkaline phosphatase were analyzed by photocolometry method and parathyroid hormone (PTH) by immune assay method. Statistical analysis was performed in the Statistica 5.0 program (StatSoft Inc., USA). Results. It was shown that intake of Alfacalcidol (0,25–0,5 mcg daily) and Quercetin granules 1.0 g three times per day provided normalization of calcium-phosphorous homeostasis, correction of hyperthyroidism but also has pronounced analgesic effect as compared with patients receiving monotherapy with calcium carbonate. Conclusions. Combined treatment with Alfacalcidol and Quercetin granules in predialysis CKD patients with secondary hyperthyroidism leads to calcium and phosphorus metabolism normalization, correction of secondary hyperthyroidism, and has an analgesic effect. |
| first_indexed | 2024-03-11T21:27:41Z |
| format | Article |
| id | doaj.art-3f7697512e674de79c17e6987972b55d |
| institution | Directory Open Access Journal |
| issn | 2224-1507 2307-1133 |
| language | English |
| last_indexed | 2024-03-11T21:27:41Z |
| publishDate | 2023-03-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Bolʹ, Sustavy, Pozvonočnik |
| spelling | doaj.art-3f7697512e674de79c17e6987972b55d2023-09-27T17:40:35ZengZaslavsky O.Yu.Bolʹ, Sustavy, Pozvonočnik2224-15072307-11332023-03-01131384510.22141/pjs.13.1.2023.356356The efficacy of combined treatment of secondary hyperthyroidism in pre-dialysis chronic kidney disease patientsL.P. Martynyuk0https://orcid.org/0000-0003-0870-2720O.I. Shershun1https://orcid.org/0000-0003-2732-6302T.L. Malska2https://orcid.org/0000-0002-9308-3065State Institution of Higher Education “I. Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine”, Ternopil, UkraineState Institution of Higher Education “I. Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine”, Ternopil, UkraineState Institution of Higher Education “I. Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine”, Ternopil, UkraineBackground. It is well known that chronic kidney disease (CKD) patients develop mineral and bone disturbances which lead to the development of renal osteodystrophy and its complications. Secondary hyperthyroidism is the main reason for the development of mineral and bone disoders in these patients. The purpose of the study was to evaluate the efficacy of combined therapy with Alfacalcidol and Quercetin in the treatment of secondary hyperthyroidism in pre-dialysis CKD patients. Materials and methods. 61 patients with CKD 3 and 4 stages aged 20–78 years were included in the study. Patients were divided into 2 groups: 35 patients received combined treatment with Alfacalcidol and Quercetin granules, and 26 patients received standard treatment with calcium carbonate. Indices of calcium, phosphorus, magnesium, and alkaline phosphatase were analyzed by photocolometry method and parathyroid hormone (PTH) by immune assay method. Statistical analysis was performed in the Statistica 5.0 program (StatSoft Inc., USA). Results. It was shown that intake of Alfacalcidol (0,25–0,5 mcg daily) and Quercetin granules 1.0 g three times per day provided normalization of calcium-phosphorous homeostasis, correction of hyperthyroidism but also has pronounced analgesic effect as compared with patients receiving monotherapy with calcium carbonate. Conclusions. Combined treatment with Alfacalcidol and Quercetin granules in predialysis CKD patients with secondary hyperthyroidism leads to calcium and phosphorus metabolism normalization, correction of secondary hyperthyroidism, and has an analgesic effect.https://pjs.zaslavsky.com.ua/index.php/journal/article/view/356chronic kidney diseasemineral and bone disorderssecondary hyperthyroidism |
| spellingShingle | L.P. Martynyuk O.I. Shershun T.L. Malska The efficacy of combined treatment of secondary hyperthyroidism in pre-dialysis chronic kidney disease patients Bolʹ, Sustavy, Pozvonočnik chronic kidney disease mineral and bone disorders secondary hyperthyroidism |
| title | The efficacy of combined treatment of secondary hyperthyroidism in pre-dialysis chronic kidney disease patients |
| title_full | The efficacy of combined treatment of secondary hyperthyroidism in pre-dialysis chronic kidney disease patients |
| title_fullStr | The efficacy of combined treatment of secondary hyperthyroidism in pre-dialysis chronic kidney disease patients |
| title_full_unstemmed | The efficacy of combined treatment of secondary hyperthyroidism in pre-dialysis chronic kidney disease patients |
| title_short | The efficacy of combined treatment of secondary hyperthyroidism in pre-dialysis chronic kidney disease patients |
| title_sort | efficacy of combined treatment of secondary hyperthyroidism in pre dialysis chronic kidney disease patients |
| topic | chronic kidney disease mineral and bone disorders secondary hyperthyroidism |
| url | https://pjs.zaslavsky.com.ua/index.php/journal/article/view/356 |
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