Strongyloides—An uncommon cause of eosinophilia whilst on durvalumab
Abstract Background In malignancy, eosinophils have been shown to play an important role in the tumour micro‐environment. Increasingly, development of eosinophilia with immune checkpoint inhibitor (ICI) use is thought to be predictive of prognosis and development of immune‐related adverse events. Ho...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-10-01
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| Series: | Cancer Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cnr2.1682 |
| _version_ | 1828204932277207040 |
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| author | Gaik Tin Quah Gillian Blanchard Neil Miller Paul Wilson Ina Nordman |
| author_facet | Gaik Tin Quah Gillian Blanchard Neil Miller Paul Wilson Ina Nordman |
| author_sort | Gaik Tin Quah |
| collection | DOAJ |
| description | Abstract Background In malignancy, eosinophils have been shown to play an important role in the tumour micro‐environment. Increasingly, development of eosinophilia with immune checkpoint inhibitor (ICI) use is thought to be predictive of prognosis and development of immune‐related adverse events. However, there are many other causes for developing eosinophilia which can contribute to the difficulties in diagnosis and management. Case Here, we present a case of Strongyloides parasitic infection as an uncommon differential for eosinophilia in a patient with lung cancer receiving a PDL‐1 ICI, durvalumab, in Australia. Conclusion This case highlights the complexities exploring the multiple potential causes of eosinophilia and the subsequent management, to allow safe continuation of ICI. |
| first_indexed | 2024-04-12T12:31:49Z |
| format | Article |
| id | doaj.art-3f76d5676bfc4c358730d5adfe2f3e2a |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-04-12T12:31:49Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-3f76d5676bfc4c358730d5adfe2f3e2a2022-12-22T03:33:00ZengWileyCancer Reports2573-83482022-10-01510n/an/a10.1002/cnr2.1682Strongyloides—An uncommon cause of eosinophilia whilst on durvalumabGaik Tin Quah0Gillian Blanchard1Neil Miller2Paul Wilson3Ina Nordman4Department of Medical Oncology, Calvary Mater Newcastle Waratah AustraliaDepartment of Medical Oncology, Calvary Mater Newcastle Waratah AustraliaDepartment of Infectious Diseases Calvary Mater Newcastle Waratah AustraliaDepartment of Infectious Diseases Calvary Mater Newcastle Waratah AustraliaDepartment of Medical Oncology, Calvary Mater Newcastle Waratah AustraliaAbstract Background In malignancy, eosinophils have been shown to play an important role in the tumour micro‐environment. Increasingly, development of eosinophilia with immune checkpoint inhibitor (ICI) use is thought to be predictive of prognosis and development of immune‐related adverse events. However, there are many other causes for developing eosinophilia which can contribute to the difficulties in diagnosis and management. Case Here, we present a case of Strongyloides parasitic infection as an uncommon differential for eosinophilia in a patient with lung cancer receiving a PDL‐1 ICI, durvalumab, in Australia. Conclusion This case highlights the complexities exploring the multiple potential causes of eosinophilia and the subsequent management, to allow safe continuation of ICI.https://doi.org/10.1002/cnr2.1682durvalumabeosinophiliaimmune checkpoint inhibitorsimmunotherapyStrongyloides |
| spellingShingle | Gaik Tin Quah Gillian Blanchard Neil Miller Paul Wilson Ina Nordman Strongyloides—An uncommon cause of eosinophilia whilst on durvalumab Cancer Reports durvalumab eosinophilia immune checkpoint inhibitors immunotherapy Strongyloides |
| title | Strongyloides—An uncommon cause of eosinophilia whilst on durvalumab |
| title_full | Strongyloides—An uncommon cause of eosinophilia whilst on durvalumab |
| title_fullStr | Strongyloides—An uncommon cause of eosinophilia whilst on durvalumab |
| title_full_unstemmed | Strongyloides—An uncommon cause of eosinophilia whilst on durvalumab |
| title_short | Strongyloides—An uncommon cause of eosinophilia whilst on durvalumab |
| title_sort | strongyloides an uncommon cause of eosinophilia whilst on durvalumab |
| topic | durvalumab eosinophilia immune checkpoint inhibitors immunotherapy Strongyloides |
| url | https://doi.org/10.1002/cnr2.1682 |
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