Novel Enterobacter Lineage as Leading Cause of Nosocomial Outbreak Involving Carbapenemase-Producing Strains
We investigated unusual carbapenemase-producing Enterobacter cloacae complex isolates (n = 8) in the novel sequence type (ST) 873, which caused nosocomial infections in 2 hospitals in France. Whole-genome sequence typing showed the 1-year persistence of the epidemic strain, which harbored a blaVIM-4...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2018-08-01
|
| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/24/8/18-0151_article |
| _version_ | 1818153858276261888 |
|---|---|
| author | Racha Beyrouthy Marion Barets Elodie Marion Cédric Dananché Olivier Dauwalder Frédéric Robin Lauraine Gauthier Agnès Jousset Laurent Dortet François Guérin Thomas Bénet Pierre Cassier Philippe Vanhems Richard Bonnet |
| author_facet | Racha Beyrouthy Marion Barets Elodie Marion Cédric Dananché Olivier Dauwalder Frédéric Robin Lauraine Gauthier Agnès Jousset Laurent Dortet François Guérin Thomas Bénet Pierre Cassier Philippe Vanhems Richard Bonnet |
| author_sort | Racha Beyrouthy |
| collection | DOAJ |
| description | We investigated unusual carbapenemase-producing Enterobacter cloacae complex isolates (n = 8) in the novel sequence type (ST) 873, which caused nosocomial infections in 2 hospitals in France. Whole-genome sequence typing showed the 1-year persistence of the epidemic strain, which harbored a blaVIM-4 ST1-IncHI2 plasmid, in 1 health institution and 2 closely related strains harboring blaCTX-M-15 in the other. These isolates formed a new subgroup in the E. hormaechei metacluster, according to their hsp60 sequences and phylogenomic analysis. The average nucleotide identities, specific biochemical properties, and pangenomic and functional investigations of isolates suggested isolates of a novel species that had acquired genes associated with adhesion and mobility. The emergence of this novel Enterobacter phylogenetic lineage within hospitals should be closely monitored because of its ability to persist and spread. |
| first_indexed | 2024-12-11T14:17:17Z |
| format | Article |
| id | doaj.art-3f76df21a4e24a1e855805efcde6c604 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-11T14:17:17Z |
| publishDate | 2018-08-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-3f76df21a4e24a1e855805efcde6c6042022-12-22T01:03:05ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592018-08-012481505151510.3201/eid2408.180151Novel Enterobacter Lineage as Leading Cause of Nosocomial Outbreak Involving Carbapenemase-Producing StrainsRacha BeyrouthyMarion BaretsElodie MarionCédric DananchéOlivier DauwalderFrédéric RobinLauraine GauthierAgnès JoussetLaurent DortetFrançois GuérinThomas BénetPierre CassierPhilippe VanhemsRichard BonnetWe investigated unusual carbapenemase-producing Enterobacter cloacae complex isolates (n = 8) in the novel sequence type (ST) 873, which caused nosocomial infections in 2 hospitals in France. Whole-genome sequence typing showed the 1-year persistence of the epidemic strain, which harbored a blaVIM-4 ST1-IncHI2 plasmid, in 1 health institution and 2 closely related strains harboring blaCTX-M-15 in the other. These isolates formed a new subgroup in the E. hormaechei metacluster, according to their hsp60 sequences and phylogenomic analysis. The average nucleotide identities, specific biochemical properties, and pangenomic and functional investigations of isolates suggested isolates of a novel species that had acquired genes associated with adhesion and mobility. The emergence of this novel Enterobacter phylogenetic lineage within hospitals should be closely monitored because of its ability to persist and spread.https://wwwnc.cdc.gov/eid/article/24/8/18-0151_articleCarbapenemaseEnterobacter cloacae complexEnterobacteriaceaeb-lactamasenosocomial outbreakVIM-4 |
| spellingShingle | Racha Beyrouthy Marion Barets Elodie Marion Cédric Dananché Olivier Dauwalder Frédéric Robin Lauraine Gauthier Agnès Jousset Laurent Dortet François Guérin Thomas Bénet Pierre Cassier Philippe Vanhems Richard Bonnet Novel Enterobacter Lineage as Leading Cause of Nosocomial Outbreak Involving Carbapenemase-Producing Strains Emerging Infectious Diseases Carbapenemase Enterobacter cloacae complex Enterobacteriaceae b-lactamase nosocomial outbreak VIM-4 |
| title | Novel Enterobacter Lineage as Leading Cause of Nosocomial Outbreak Involving Carbapenemase-Producing Strains |
| title_full | Novel Enterobacter Lineage as Leading Cause of Nosocomial Outbreak Involving Carbapenemase-Producing Strains |
| title_fullStr | Novel Enterobacter Lineage as Leading Cause of Nosocomial Outbreak Involving Carbapenemase-Producing Strains |
| title_full_unstemmed | Novel Enterobacter Lineage as Leading Cause of Nosocomial Outbreak Involving Carbapenemase-Producing Strains |
| title_short | Novel Enterobacter Lineage as Leading Cause of Nosocomial Outbreak Involving Carbapenemase-Producing Strains |
| title_sort | novel enterobacter lineage as leading cause of nosocomial outbreak involving carbapenemase producing strains |
| topic | Carbapenemase Enterobacter cloacae complex Enterobacteriaceae b-lactamase nosocomial outbreak VIM-4 |
| url | https://wwwnc.cdc.gov/eid/article/24/8/18-0151_article |
| work_keys_str_mv | AT rachabeyrouthy novelenterobacterlineageasleadingcauseofnosocomialoutbreakinvolvingcarbapenemaseproducingstrains AT marionbarets novelenterobacterlineageasleadingcauseofnosocomialoutbreakinvolvingcarbapenemaseproducingstrains AT elodiemarion novelenterobacterlineageasleadingcauseofnosocomialoutbreakinvolvingcarbapenemaseproducingstrains AT cedricdananche novelenterobacterlineageasleadingcauseofnosocomialoutbreakinvolvingcarbapenemaseproducingstrains AT olivierdauwalder novelenterobacterlineageasleadingcauseofnosocomialoutbreakinvolvingcarbapenemaseproducingstrains AT fredericrobin novelenterobacterlineageasleadingcauseofnosocomialoutbreakinvolvingcarbapenemaseproducingstrains AT laurainegauthier novelenterobacterlineageasleadingcauseofnosocomialoutbreakinvolvingcarbapenemaseproducingstrains AT agnesjousset novelenterobacterlineageasleadingcauseofnosocomialoutbreakinvolvingcarbapenemaseproducingstrains AT laurentdortet novelenterobacterlineageasleadingcauseofnosocomialoutbreakinvolvingcarbapenemaseproducingstrains AT francoisguerin novelenterobacterlineageasleadingcauseofnosocomialoutbreakinvolvingcarbapenemaseproducingstrains AT thomasbenet novelenterobacterlineageasleadingcauseofnosocomialoutbreakinvolvingcarbapenemaseproducingstrains AT pierrecassier novelenterobacterlineageasleadingcauseofnosocomialoutbreakinvolvingcarbapenemaseproducingstrains AT philippevanhems novelenterobacterlineageasleadingcauseofnosocomialoutbreakinvolvingcarbapenemaseproducingstrains AT richardbonnet novelenterobacterlineageasleadingcauseofnosocomialoutbreakinvolvingcarbapenemaseproducingstrains |