Cystic Parathyroid Adenomas as a Risk Factor for Severe Hypercalcemia
(1) Background: Parathyroid cystic adenomas (PCA) are rare entities representing only 0.5–1% of parathyroid adenomas, accounting for 1–2% of cases of primary hyperparathyroidism (PHPT). The purpose of this study was to compare classical and functional/secreting cystic parathyroid lesions and identif...
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MDPI AG
2023-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/15/4939 |
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| author | Monika Kaszczewska Witold Chudziński Piotr Kaszczewski Michał Popow Jakub Grzybowski Anna Skowrońska-Szcześniak Herbert Kozubek Zbigniew Gałązka |
| author_facet | Monika Kaszczewska Witold Chudziński Piotr Kaszczewski Michał Popow Jakub Grzybowski Anna Skowrońska-Szcześniak Herbert Kozubek Zbigniew Gałązka |
| author_sort | Monika Kaszczewska |
| collection | DOAJ |
| description | (1) Background: Parathyroid cystic adenomas (PCA) are rare entities representing only 0.5–1% of parathyroid adenomas, accounting for 1–2% of cases of primary hyperparathyroidism (PHPT). The purpose of this study was to compare classical and functional/secreting cystic parathyroid lesions and identify risk factors for severe hypercalcemia; (2) Methods: A total of 17 patients with PHPT and parathyroid cysts (study group) were compared with the group of 100 patients with hyperparathyroidism caused by adenoma or hyperplasia (control group). In both groups the majority were women (88% vs. 12%, with gender ratio 7, 3:1). The patients were examined preoperatively and postoperatively: PTH, creatine, calcium and phosphate serum and urine concentrations and calcidiol serum levels were assessed; (3) Results: Patients with parathyroid cyst had statistically higher PTH and calcium serum concentration, higher calciuria and lower serum phosphate concentration. There were no statistically significant differences in the concentration of creatine in serum and urine and tubular reabsorption of phosphorus (TRP); (4) Conclusions: Due to higher PTH and calcium levels, cystic parathyroid adenomas could be one of the rare risk factors for severe hypercalcemia and hypercalcemic crisis which can be life threatening. |
| first_indexed | 2024-03-11T00:24:12Z |
| format | Article |
| id | doaj.art-3f79671ddab04f7cad9ad410954d7099 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T00:24:12Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-3f79671ddab04f7cad9ad410954d70992023-11-18T23:07:15ZengMDPI AGJournal of Clinical Medicine2077-03832023-07-011215493910.3390/jcm12154939Cystic Parathyroid Adenomas as a Risk Factor for Severe HypercalcemiaMonika Kaszczewska0Witold Chudziński1Piotr Kaszczewski2Michał Popow3Jakub Grzybowski4Anna Skowrońska-Szcześniak5Herbert Kozubek6Zbigniew Gałązka7Department of General, Vascular, Endocrine and Transplantation Surgery, Medical University of Warsaw, 02-097 Warsaw, PolandDepartment of General, Vascular, Endocrine and Transplantation Surgery, Medical University of Warsaw, 02-097 Warsaw, PolandDepartment of General, Vascular, Endocrine and Transplantation Surgery, Medical University of Warsaw, 02-097 Warsaw, PolandDepartment of Endocrinology and Internal Medicine, Medical University of Warsaw, 02-097 Warsaw, PolandDepartment of Pathology, Medical University of Warsaw, 02-097 Warsaw, PolandDepartment of Endocrinology and Internal Medicine, Medical University of Warsaw, 02-097 Warsaw, PolandDepartment of General, Vascular, Endocrine and Transplantation Surgery, Medical University of Warsaw, 02-097 Warsaw, PolandDepartment of General, Vascular, Endocrine and Transplantation Surgery, Medical University of Warsaw, 02-097 Warsaw, Poland(1) Background: Parathyroid cystic adenomas (PCA) are rare entities representing only 0.5–1% of parathyroid adenomas, accounting for 1–2% of cases of primary hyperparathyroidism (PHPT). The purpose of this study was to compare classical and functional/secreting cystic parathyroid lesions and identify risk factors for severe hypercalcemia; (2) Methods: A total of 17 patients with PHPT and parathyroid cysts (study group) were compared with the group of 100 patients with hyperparathyroidism caused by adenoma or hyperplasia (control group). In both groups the majority were women (88% vs. 12%, with gender ratio 7, 3:1). The patients were examined preoperatively and postoperatively: PTH, creatine, calcium and phosphate serum and urine concentrations and calcidiol serum levels were assessed; (3) Results: Patients with parathyroid cyst had statistically higher PTH and calcium serum concentration, higher calciuria and lower serum phosphate concentration. There were no statistically significant differences in the concentration of creatine in serum and urine and tubular reabsorption of phosphorus (TRP); (4) Conclusions: Due to higher PTH and calcium levels, cystic parathyroid adenomas could be one of the rare risk factors for severe hypercalcemia and hypercalcemic crisis which can be life threatening.https://www.mdpi.com/2077-0383/12/15/4939parathyroid cystcystic parathyroid adenomaprimary hyperparathyroidismsevere hypercalcemiahypercalcemic crisis |
| spellingShingle | Monika Kaszczewska Witold Chudziński Piotr Kaszczewski Michał Popow Jakub Grzybowski Anna Skowrońska-Szcześniak Herbert Kozubek Zbigniew Gałązka Cystic Parathyroid Adenomas as a Risk Factor for Severe Hypercalcemia Journal of Clinical Medicine parathyroid cyst cystic parathyroid adenoma primary hyperparathyroidism severe hypercalcemia hypercalcemic crisis |
| title | Cystic Parathyroid Adenomas as a Risk Factor for Severe Hypercalcemia |
| title_full | Cystic Parathyroid Adenomas as a Risk Factor for Severe Hypercalcemia |
| title_fullStr | Cystic Parathyroid Adenomas as a Risk Factor for Severe Hypercalcemia |
| title_full_unstemmed | Cystic Parathyroid Adenomas as a Risk Factor for Severe Hypercalcemia |
| title_short | Cystic Parathyroid Adenomas as a Risk Factor for Severe Hypercalcemia |
| title_sort | cystic parathyroid adenomas as a risk factor for severe hypercalcemia |
| topic | parathyroid cyst cystic parathyroid adenoma primary hyperparathyroidism severe hypercalcemia hypercalcemic crisis |
| url | https://www.mdpi.com/2077-0383/12/15/4939 |
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