Cytokine Storm Management in Severe COVID-19: Exploring Four Effective Medicinal Plants as Potential Interventions
COVID-19, caused by the SARS-CoV-2 virus, has emerged as a global health threat. Due to coronovirus mutations and genetic variations, effective treatments remain elusive. Currently, the primary strategy for disease management revolves around coronovirus vaccines, representing the sole avenue for dis...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2023-12-01
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| Series: | Trends in Pharmaceutical Sciences |
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| Online Access: | https://tips.sums.ac.ir/article_49800_518a1529b83d4e0ec8a03149d5853529.pdf |
| _version_ | 1797216823804952576 |
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| author | Mina Shafiee Samira Sadat Abolmaali Mohsen Salmanpour Ehsan Amiri Alimohammad Tamaddon |
| author_facet | Mina Shafiee Samira Sadat Abolmaali Mohsen Salmanpour Ehsan Amiri Alimohammad Tamaddon |
| author_sort | Mina Shafiee |
| collection | DOAJ |
| description | COVID-19, caused by the SARS-CoV-2 virus, has emerged as a global health threat. Due to coronovirus mutations and genetic variations, effective treatments remain elusive. Currently, the primary strategy for disease management revolves around coronovirus vaccines, representing the sole avenue for disease control. A prominent factor in the pathogenesis of COVID-19 is the severe inflammation triggered by a phenomenon known as cytokine storm. This review delves into the pivotal role of interleukin-6 (IL-6) in orchestrating the cytokine storm and explores the intricate network of signaling pathways and inhibitors, including phytochemicals. Numerous clinical trials have explored the potential of anti-cytokine agents and medicinal plants with cytokine-modulating attributes in COVID-19 patients. According to various studies investigating the effects of medicinal plants on COVID-19, four specific plants—Silybum marianum L., Tanacetum parthenium L., Curcuma longa L., and Zingiber officinale Rosc.—have exhibited significant anti-IL-6 signaling properties. However, further rigorous clinical data are needed to establish their prophylactic or therapeutic efficacy. Overall, both in-vivo and clinical studies suggest that the aforementioned medicinal plants, endowed with proven anti-inflammatory and immune-modulatory properties, particularly through IL-6 reduction, could make valuable contributions to the management of COVID-19. |
| first_indexed | 2024-04-24T11:52:05Z |
| format | Article |
| id | doaj.art-3f7a0d4826ab4de29aa81b8621ecddab |
| institution | Directory Open Access Journal |
| issn | 2423-5652 |
| language | English |
| last_indexed | 2024-04-24T11:52:05Z |
| publishDate | 2023-12-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Trends in Pharmaceutical Sciences |
| spelling | doaj.art-3f7a0d4826ab4de29aa81b8621ecddab2024-04-09T07:38:53ZengShiraz University of Medical SciencesTrends in Pharmaceutical Sciences2423-56522023-12-019427928610.30476/tips.2023.99758.120949800Cytokine Storm Management in Severe COVID-19: Exploring Four Effective Medicinal Plants as Potential InterventionsMina Shafiee0Samira Sadat Abolmaali1Mohsen Salmanpour2Ehsan Amiri3Alimohammad Tamaddon4Center for Nanotechnology in Drug Delivery, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Center for Nanotechnology in Drug Delivery, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Center for Nanotechnology in Drug Delivery, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Phytopharmaceuticals (Traditional Pharmacy), Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranCenter for Nanotechnology in Drug Delivery, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.COVID-19, caused by the SARS-CoV-2 virus, has emerged as a global health threat. Due to coronovirus mutations and genetic variations, effective treatments remain elusive. Currently, the primary strategy for disease management revolves around coronovirus vaccines, representing the sole avenue for disease control. A prominent factor in the pathogenesis of COVID-19 is the severe inflammation triggered by a phenomenon known as cytokine storm. This review delves into the pivotal role of interleukin-6 (IL-6) in orchestrating the cytokine storm and explores the intricate network of signaling pathways and inhibitors, including phytochemicals. Numerous clinical trials have explored the potential of anti-cytokine agents and medicinal plants with cytokine-modulating attributes in COVID-19 patients. According to various studies investigating the effects of medicinal plants on COVID-19, four specific plants—Silybum marianum L., Tanacetum parthenium L., Curcuma longa L., and Zingiber officinale Rosc.—have exhibited significant anti-IL-6 signaling properties. However, further rigorous clinical data are needed to establish their prophylactic or therapeutic efficacy. Overall, both in-vivo and clinical studies suggest that the aforementioned medicinal plants, endowed with proven anti-inflammatory and immune-modulatory properties, particularly through IL-6 reduction, could make valuable contributions to the management of COVID-19.https://tips.sums.ac.ir/article_49800_518a1529b83d4e0ec8a03149d5853529.pdfcovid-19cytokine storminterleukin-6herbal medicine |
| spellingShingle | Mina Shafiee Samira Sadat Abolmaali Mohsen Salmanpour Ehsan Amiri Alimohammad Tamaddon Cytokine Storm Management in Severe COVID-19: Exploring Four Effective Medicinal Plants as Potential Interventions Trends in Pharmaceutical Sciences covid-19 cytokine storm interleukin-6 herbal medicine |
| title | Cytokine Storm Management in Severe COVID-19: Exploring Four Effective Medicinal Plants as Potential Interventions |
| title_full | Cytokine Storm Management in Severe COVID-19: Exploring Four Effective Medicinal Plants as Potential Interventions |
| title_fullStr | Cytokine Storm Management in Severe COVID-19: Exploring Four Effective Medicinal Plants as Potential Interventions |
| title_full_unstemmed | Cytokine Storm Management in Severe COVID-19: Exploring Four Effective Medicinal Plants as Potential Interventions |
| title_short | Cytokine Storm Management in Severe COVID-19: Exploring Four Effective Medicinal Plants as Potential Interventions |
| title_sort | cytokine storm management in severe covid 19 exploring four effective medicinal plants as potential interventions |
| topic | covid-19 cytokine storm interleukin-6 herbal medicine |
| url | https://tips.sums.ac.ir/article_49800_518a1529b83d4e0ec8a03149d5853529.pdf |
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