Dual control of pcdh8l/PCNS expression and function in Xenopus laevis neural crest cells by adam13/33 via the transcription factors tfap2α and arid3a

Dual control of pcdh8l/PCNS expression and function in Xenopus laevis neural crest cells by adam13/33 via the transcription factors tfap2α and arid3a

Adam13/33 is a cell surface metalloprotease critical for cranial neural crest (CNC) cell migration. It can cleave multiple substrates including itself, fibronectin, ephrinB, cadherin-11, pcdh8 and pcdh8l (this work). Cleavage of cadherin-11 produces an extracellular fragment that promotes CNC migrat...

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Bibliographic Details
Main Authors: Vikram Khedgikar, Genevieve Abbruzzese, Ketan Mathavan, Hannah Szydlo, Helene Cousin, Dominique Alfandari
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
neural crest
ADAM
metalloprotease
protocadherin
cell migration
embryo
Online Access:https://elifesciences.org/articles/26898

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