The Neutrophil-to-Lymphocyte Ratio is Related to Disease Activity in Relapsing Remitting Multiple Sclerosis
Background: The role of the neutrophil-to-lymphocyte ratio (NLR) of peripheral blood has been investigated in relation to several autoimmune diseases. Limited studies have addressed the significance of the NLR in terms of being a marker of disease activity in multiple sclerosis (MS). Methods: This i...
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MDPI AG
2019-09-01
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| Online Access: | https://www.mdpi.com/2073-4409/8/10/1114 |
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| author | Emanuele D’Amico Aurora Zanghì Alessandra Romano Mariangela Sciandra Giuseppe Alberto Maria Palumbo Francesco Patti |
| author_facet | Emanuele D’Amico Aurora Zanghì Alessandra Romano Mariangela Sciandra Giuseppe Alberto Maria Palumbo Francesco Patti |
| author_sort | Emanuele D’Amico |
| collection | DOAJ |
| description | Background: The role of the neutrophil-to-lymphocyte ratio (NLR) of peripheral blood has been investigated in relation to several autoimmune diseases. Limited studies have addressed the significance of the NLR in terms of being a marker of disease activity in multiple sclerosis (MS). Methods: This is a retrospective study in relapsing−remitting MS patients (RRMS) admitted to the tertiary MS center of Catania, Italy during the period of 1 January to 31 December 2018. The aim of the present study was to investigate the significance of the NLR in reflecting the disease activity in a cohort of early diagnosed RRMS patients. Results: Among a total sample of 132 patients diagnosed with RRMS, 84 were enrolled in the present study. In the association analysis, a relation between the NLR value and disease activity at onset was found (V-Cramer 0.271, <i>p</i> = 0.013). In the logistic regression model, the variable NLR (<i>p</i> = 0.03 ExpB 3.5, CI 95% 1.089−11.4) was related to disease activity at onset. Conclusion: An elevated NLR is associated with disease activity at onset in RRMS patients. More large-scale studies with a longer follow-up are needed. |
| first_indexed | 2024-03-12T08:29:36Z |
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| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T08:29:36Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-3f7ba75792f14123884295f8d4c5f9d52023-09-02T17:50:33ZengMDPI AGCells2073-44092019-09-01810111410.3390/cells8101114cells8101114The Neutrophil-to-Lymphocyte Ratio is Related to Disease Activity in Relapsing Remitting Multiple SclerosisEmanuele D’Amico0Aurora Zanghì1Alessandra Romano2Mariangela Sciandra3Giuseppe Alberto Maria Palumbo4Francesco Patti5Department “G.F. Ingrassia”, MS Center, University of Catania, Via Santa Sofia 78, 95123 Catania, ItalyDepartment “G.F. Ingrassia”, MS Center, University of Catania, Via Santa Sofia 78, 95123 Catania, ItalyDepartment of Surgery and Medical Specialties, Division of Hematology-A.O.U. Policlinico-OVE, Catania, Via Santa Sofia 78, 95123 Catania, ItalyDepartment of Economics, Business and Statistics, University of Palermo, 90128 Palermo, ItalyDepartment “G.F. Ingrassia”, Division of Hematology-A.O.U. Policlinico-OVE, Catania, University of Catania, Via Santa Sofia 78, 95123 Catania, ItalyDepartment “G.F. Ingrassia”, MS Center, University of Catania, Via Santa Sofia 78, 95123 Catania, ItalyBackground: The role of the neutrophil-to-lymphocyte ratio (NLR) of peripheral blood has been investigated in relation to several autoimmune diseases. Limited studies have addressed the significance of the NLR in terms of being a marker of disease activity in multiple sclerosis (MS). Methods: This is a retrospective study in relapsing−remitting MS patients (RRMS) admitted to the tertiary MS center of Catania, Italy during the period of 1 January to 31 December 2018. The aim of the present study was to investigate the significance of the NLR in reflecting the disease activity in a cohort of early diagnosed RRMS patients. Results: Among a total sample of 132 patients diagnosed with RRMS, 84 were enrolled in the present study. In the association analysis, a relation between the NLR value and disease activity at onset was found (V-Cramer 0.271, <i>p</i> = 0.013). In the logistic regression model, the variable NLR (<i>p</i> = 0.03 ExpB 3.5, CI 95% 1.089−11.4) was related to disease activity at onset. Conclusion: An elevated NLR is associated with disease activity at onset in RRMS patients. More large-scale studies with a longer follow-up are needed.https://www.mdpi.com/2073-4409/8/10/1114neutrophilslymphocytesNLRmultiple sclerosisdisease activity |
| spellingShingle | Emanuele D’Amico Aurora Zanghì Alessandra Romano Mariangela Sciandra Giuseppe Alberto Maria Palumbo Francesco Patti The Neutrophil-to-Lymphocyte Ratio is Related to Disease Activity in Relapsing Remitting Multiple Sclerosis Cells neutrophils lymphocytes NLR multiple sclerosis disease activity |
| title | The Neutrophil-to-Lymphocyte Ratio is Related to Disease Activity in Relapsing Remitting Multiple Sclerosis |
| title_full | The Neutrophil-to-Lymphocyte Ratio is Related to Disease Activity in Relapsing Remitting Multiple Sclerosis |
| title_fullStr | The Neutrophil-to-Lymphocyte Ratio is Related to Disease Activity in Relapsing Remitting Multiple Sclerosis |
| title_full_unstemmed | The Neutrophil-to-Lymphocyte Ratio is Related to Disease Activity in Relapsing Remitting Multiple Sclerosis |
| title_short | The Neutrophil-to-Lymphocyte Ratio is Related to Disease Activity in Relapsing Remitting Multiple Sclerosis |
| title_sort | neutrophil to lymphocyte ratio is related to disease activity in relapsing remitting multiple sclerosis |
| topic | neutrophils lymphocytes NLR multiple sclerosis disease activity |
| url | https://www.mdpi.com/2073-4409/8/10/1114 |
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