Association Between Polymorphisms of the Complement 3 Gene and Schizophrenia in a Han Chinese Population
Background/Aims: Schizophrenia is a severe psychiatric disorder, and complement 3 (C3) is closely related to schizophrenia. We investigated the association between C3 polymorphisms and schizophrenia in a Northeast Han Chinese population. Methods: A total of 2240 Chinese people, consisting of 1086 pa...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cell Physiol Biochem Press GmbH & Co KG
2018-05-01
|
| Series: | Cellular Physiology and Biochemistry |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/489654 |
| _version_ | 1831523123209437184 |
|---|---|
| author | Shangchao Zhang Na Zhou Rui Liu Wenwang Rao Mingjia Yang Bonan Cao Guojun Kang Qi Kang Xiaojing Zhu Rixin Li Yaqin Yu Qiong Yu |
| author_facet | Shangchao Zhang Na Zhou Rui Liu Wenwang Rao Mingjia Yang Bonan Cao Guojun Kang Qi Kang Xiaojing Zhu Rixin Li Yaqin Yu Qiong Yu |
| author_sort | Shangchao Zhang |
| collection | DOAJ |
| description | Background/Aims: Schizophrenia is a severe psychiatric disorder, and complement 3 (C3) is closely related to schizophrenia. We investigated the association between C3 polymorphisms and schizophrenia in a Northeast Han Chinese population. Methods: A total of 2240 Chinese people, consisting of 1086 patients with schizophrenia and 1154 healthy controls, were recruited for this study. Ten single nucleotide polymorphisms (SNPs; rs11569562, rs344555, rs2241393, rs2241392, rs11569514, rs445750, rs451760, rs11672613, rs2230205, and rs2250656) in C3 were selected and genotyped. Results: Genotype distribution analysis indicated that rs11569514 was significantly associated with schizophrenia. In the dominant model (AA vs. GG+GA genotypes), we found a significant protective effect for rs344555 against schizophrenia (odds ratio [OR]: 0.72, 95% confidence interval [CI]: 0.53–0.99, P = 0.04). In the codominant model (TT vs. AA), we found a significant risk effect for rs11569514 on schizophrenia (OR: 4.39, 95% CI: 2.06–9.37, P < 0.001). Haplotypes, including TG (rs11569562 and rs344555), TGG (rs11569562-rs344555-rs2241393), AG (rs344555-rs2241393), CGGGT (rs11569562-rs344555-rs2241393-rs2241392-rs11569514), and ACGTG (rs11569514-rs445750-rs451760-rs11672613-rs2230205), showed either a risk or protective role for schizophrenia. Conclusions: SNP rs11569514 in C3 and haplotypes of C3 variants were associated with schizophrenia in a Han Chinese population. |
| first_indexed | 2024-12-14T11:11:34Z |
| format | Article |
| id | doaj.art-3f8096f36eaf4a33a3082bbca659feeb |
| institution | Directory Open Access Journal |
| issn | 1015-8987 1421-9778 |
| language | English |
| last_indexed | 2024-12-14T11:11:34Z |
| publishDate | 2018-05-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Cellular Physiology and Biochemistry |
| spelling | doaj.art-3f8096f36eaf4a33a3082bbca659feeb2022-12-21T23:04:15ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782018-05-014662480248610.1159/000489654489654Association Between Polymorphisms of the Complement 3 Gene and Schizophrenia in a Han Chinese PopulationShangchao ZhangNa ZhouRui LiuWenwang RaoMingjia YangBonan CaoGuojun KangQi KangXiaojing ZhuRixin LiYaqin YuQiong YuBackground/Aims: Schizophrenia is a severe psychiatric disorder, and complement 3 (C3) is closely related to schizophrenia. We investigated the association between C3 polymorphisms and schizophrenia in a Northeast Han Chinese population. Methods: A total of 2240 Chinese people, consisting of 1086 patients with schizophrenia and 1154 healthy controls, were recruited for this study. Ten single nucleotide polymorphisms (SNPs; rs11569562, rs344555, rs2241393, rs2241392, rs11569514, rs445750, rs451760, rs11672613, rs2230205, and rs2250656) in C3 were selected and genotyped. Results: Genotype distribution analysis indicated that rs11569514 was significantly associated with schizophrenia. In the dominant model (AA vs. GG+GA genotypes), we found a significant protective effect for rs344555 against schizophrenia (odds ratio [OR]: 0.72, 95% confidence interval [CI]: 0.53–0.99, P = 0.04). In the codominant model (TT vs. AA), we found a significant risk effect for rs11569514 on schizophrenia (OR: 4.39, 95% CI: 2.06–9.37, P < 0.001). Haplotypes, including TG (rs11569562 and rs344555), TGG (rs11569562-rs344555-rs2241393), AG (rs344555-rs2241393), CGGGT (rs11569562-rs344555-rs2241393-rs2241392-rs11569514), and ACGTG (rs11569514-rs445750-rs451760-rs11672613-rs2230205), showed either a risk or protective role for schizophrenia. Conclusions: SNP rs11569514 in C3 and haplotypes of C3 variants were associated with schizophrenia in a Han Chinese population.https://www.karger.com/Article/FullText/489654SchizophreniaComplement 3 geneSingle nucleotide polymorphisms (SNPs) |
| spellingShingle | Shangchao Zhang Na Zhou Rui Liu Wenwang Rao Mingjia Yang Bonan Cao Guojun Kang Qi Kang Xiaojing Zhu Rixin Li Yaqin Yu Qiong Yu Association Between Polymorphisms of the Complement 3 Gene and Schizophrenia in a Han Chinese Population Cellular Physiology and Biochemistry Schizophrenia Complement 3 gene Single nucleotide polymorphisms (SNPs) |
| title | Association Between Polymorphisms of the Complement 3 Gene and Schizophrenia in a Han Chinese Population |
| title_full | Association Between Polymorphisms of the Complement 3 Gene and Schizophrenia in a Han Chinese Population |
| title_fullStr | Association Between Polymorphisms of the Complement 3 Gene and Schizophrenia in a Han Chinese Population |
| title_full_unstemmed | Association Between Polymorphisms of the Complement 3 Gene and Schizophrenia in a Han Chinese Population |
| title_short | Association Between Polymorphisms of the Complement 3 Gene and Schizophrenia in a Han Chinese Population |
| title_sort | association between polymorphisms of the complement 3 gene and schizophrenia in a han chinese population |
| topic | Schizophrenia Complement 3 gene Single nucleotide polymorphisms (SNPs) |
| url | https://www.karger.com/Article/FullText/489654 |
| work_keys_str_mv | AT shangchaozhang associationbetweenpolymorphismsofthecomplement3geneandschizophreniainahanchinesepopulation AT nazhou associationbetweenpolymorphismsofthecomplement3geneandschizophreniainahanchinesepopulation AT ruiliu associationbetweenpolymorphismsofthecomplement3geneandschizophreniainahanchinesepopulation AT wenwangrao associationbetweenpolymorphismsofthecomplement3geneandschizophreniainahanchinesepopulation AT mingjiayang associationbetweenpolymorphismsofthecomplement3geneandschizophreniainahanchinesepopulation AT bonancao associationbetweenpolymorphismsofthecomplement3geneandschizophreniainahanchinesepopulation AT guojunkang associationbetweenpolymorphismsofthecomplement3geneandschizophreniainahanchinesepopulation AT qikang associationbetweenpolymorphismsofthecomplement3geneandschizophreniainahanchinesepopulation AT xiaojingzhu associationbetweenpolymorphismsofthecomplement3geneandschizophreniainahanchinesepopulation AT rixinli associationbetweenpolymorphismsofthecomplement3geneandschizophreniainahanchinesepopulation AT yaqinyu associationbetweenpolymorphismsofthecomplement3geneandschizophreniainahanchinesepopulation AT qiongyu associationbetweenpolymorphismsofthecomplement3geneandschizophreniainahanchinesepopulation |