Closed-state inactivation and pore-blocker modulation mechanisms of human CaV2.2

Closed-state inactivation and pore-blocker modulation mechanisms of human CaV2.2

Summary: N-type voltage-gated calcium (CaV) channels mediate Ca2+ influx at presynaptic terminals in response to action potentials and play vital roles in synaptogenesis, release of neurotransmitters, and nociceptive transmission. Here, we elucidate a cryo-electron microscopy (cryo-EM) structure of...

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Bibliographic Details
Main Authors: Yanli Dong, Yiwei Gao, Shuai Xu, Yuhang Wang, Zhuoya Yu, Yue Li, Bin Li, Tian Yuan, Bei Yang, Xuejun Cai Zhang, Daohua Jiang, Zhuo Huang, Yan Zhao
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Cell Reports
Subjects:
CaV2.2
closed-state inactivation
channel blocker
ziconotide
N-type
voltage-gated calcium channel
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721014042

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