Functional Imaging of Hypoxia: PET and MRI
Molecular and functional imaging have critical roles in cancer care. Existing evidence suggests that noninvasive detection of hypoxia within a particular type of cancer can provide new information regarding the relationship between hypoxia, cancer aggressiveness and altered therapeutic responses. Fo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/13/3336 |
| _version_ | 1797591959195353088 |
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| author | Ryan C. Perez DaeHee Kim Aaron W. P. Maxwell Juan C. Camacho |
| author_facet | Ryan C. Perez DaeHee Kim Aaron W. P. Maxwell Juan C. Camacho |
| author_sort | Ryan C. Perez |
| collection | DOAJ |
| description | Molecular and functional imaging have critical roles in cancer care. Existing evidence suggests that noninvasive detection of hypoxia within a particular type of cancer can provide new information regarding the relationship between hypoxia, cancer aggressiveness and altered therapeutic responses. Following the identification of hypoxia inducible factor (HIF), significant progress in understanding the regulation of hypoxia-induced genes has been made. These advances have provided the ability to therapeutically target HIF and tumor-associated hypoxia. Therefore, by utilizing the molecular basis of hypoxia, hypoxia-based theranostic strategies are in the process of being developed which will further personalize care for cancer patients. The aim of this review is to provide an overview of the significance of tumor hypoxia and its relevance in cancer management as well as to lay out the role of imaging in detecting hypoxia within the context of cancer. |
| first_indexed | 2024-03-11T01:45:59Z |
| format | Article |
| id | doaj.art-3f8180d66aae4df98667089d38e2b48e |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T01:45:59Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-3f8180d66aae4df98667089d38e2b48e2023-11-18T16:15:32ZengMDPI AGCancers2072-66942023-06-011513333610.3390/cancers15133336Functional Imaging of Hypoxia: PET and MRIRyan C. Perez0DaeHee Kim1Aaron W. P. Maxwell2Juan C. Camacho3Florida State University College of Medicine, Tallahassee, FL 32306, USADepartment of Diagnostic Imaging, The Warren Alpert Medical School, Brown University, Providence, RI 02903, USADepartment of Diagnostic Imaging, The Warren Alpert Medical School, Brown University, Providence, RI 02903, USADepartment of Clinical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306, USAMolecular and functional imaging have critical roles in cancer care. Existing evidence suggests that noninvasive detection of hypoxia within a particular type of cancer can provide new information regarding the relationship between hypoxia, cancer aggressiveness and altered therapeutic responses. Following the identification of hypoxia inducible factor (HIF), significant progress in understanding the regulation of hypoxia-induced genes has been made. These advances have provided the ability to therapeutically target HIF and tumor-associated hypoxia. Therefore, by utilizing the molecular basis of hypoxia, hypoxia-based theranostic strategies are in the process of being developed which will further personalize care for cancer patients. The aim of this review is to provide an overview of the significance of tumor hypoxia and its relevance in cancer management as well as to lay out the role of imaging in detecting hypoxia within the context of cancer.https://www.mdpi.com/2072-6694/15/13/3336hypoxiamagnetic resonance imagingpositron emission tomographycarcinogenesistreatment resistance |
| spellingShingle | Ryan C. Perez DaeHee Kim Aaron W. P. Maxwell Juan C. Camacho Functional Imaging of Hypoxia: PET and MRI Cancers hypoxia magnetic resonance imaging positron emission tomography carcinogenesis treatment resistance |
| title | Functional Imaging of Hypoxia: PET and MRI |
| title_full | Functional Imaging of Hypoxia: PET and MRI |
| title_fullStr | Functional Imaging of Hypoxia: PET and MRI |
| title_full_unstemmed | Functional Imaging of Hypoxia: PET and MRI |
| title_short | Functional Imaging of Hypoxia: PET and MRI |
| title_sort | functional imaging of hypoxia pet and mri |
| topic | hypoxia magnetic resonance imaging positron emission tomography carcinogenesis treatment resistance |
| url | https://www.mdpi.com/2072-6694/15/13/3336 |
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