Plasmablastic lymphoma in Malawi
Abstract Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV are highly endemic. We identified 12 patients with pathologically confirmed PBL from a prospective cohort in Lilongwe, Malawi. Median age was 46 (range 26–71), seven (58%) were...
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| Format: | Article |
| Language: | English |
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BMC
2018-06-01
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| Series: | Infectious Agents and Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13027-018-0195-4 |
| _version_ | 1819082900882063360 |
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| author | Takondwa Zuze Matthew S. Painschab Ryan Seguin Evarista Kudowa Bongani Kaimila Edwards Kasonkanji Tamiwe Tomoka Bal Mukunda Dhungel Maurice Mulenga Maria Chikasema Blessings Tewete Asekanadziwa Ntangwanika Sarah Chiyoyola Fred Chimzimu Coxcilly Kampani Robert Krysiak Nathan D. Montgomery Yuri Fedoriw Satish Gopal |
| author_facet | Takondwa Zuze Matthew S. Painschab Ryan Seguin Evarista Kudowa Bongani Kaimila Edwards Kasonkanji Tamiwe Tomoka Bal Mukunda Dhungel Maurice Mulenga Maria Chikasema Blessings Tewete Asekanadziwa Ntangwanika Sarah Chiyoyola Fred Chimzimu Coxcilly Kampani Robert Krysiak Nathan D. Montgomery Yuri Fedoriw Satish Gopal |
| author_sort | Takondwa Zuze |
| collection | DOAJ |
| description | Abstract Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV are highly endemic. We identified 12 patients with pathologically confirmed PBL from a prospective cohort in Lilongwe, Malawi. Median age was 46 (range 26–71), seven (58%) were male, and six (50%) were HIV-positive. Eight patients were treated with CHOP and four with a modified EPOCH regimen. One-year overall survival was 56% (95% CI 24–79%), without clear differences based on HIV status. PBL occurs in Malawi in HIV-positive and HIV-negative individuals and can be treated successfully with curative intent, even in a low-resource setting in SSA. |
| first_indexed | 2024-12-21T20:24:01Z |
| format | Article |
| id | doaj.art-3f82c56fb85e494a85160f3e0804d2fc |
| institution | Directory Open Access Journal |
| issn | 1750-9378 |
| language | English |
| last_indexed | 2024-12-21T20:24:01Z |
| publishDate | 2018-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Agents and Cancer |
| spelling | doaj.art-3f82c56fb85e494a85160f3e0804d2fc2022-12-21T18:51:25ZengBMCInfectious Agents and Cancer1750-93782018-06-011311410.1186/s13027-018-0195-4Plasmablastic lymphoma in MalawiTakondwa Zuze0Matthew S. Painschab1Ryan Seguin2Evarista Kudowa3Bongani Kaimila4Edwards Kasonkanji5Tamiwe Tomoka6Bal Mukunda Dhungel7Maurice Mulenga8Maria Chikasema9Blessings Tewete10Asekanadziwa Ntangwanika11Sarah Chiyoyola12Fred Chimzimu13Coxcilly Kampani14Robert Krysiak15Nathan D. Montgomery16Yuri Fedoriw17Satish Gopal18UNC Project-MalawiUNC Project-MalawiUNC Project-MalawiUNC Project-MalawiUNC Project-MalawiUNC Project-MalawiUNC Project-MalawiUNC Project-MalawiKamuzu Central HospitalUNC Project-MalawiUNC Project-MalawiUNC Project-MalawiUNC Project-MalawiUNC Project-MalawiUNC Project-MalawiUNC Project-MalawiUniversity of North CarolinaUniversity of North CarolinaUNC Project-MalawiAbstract Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV are highly endemic. We identified 12 patients with pathologically confirmed PBL from a prospective cohort in Lilongwe, Malawi. Median age was 46 (range 26–71), seven (58%) were male, and six (50%) were HIV-positive. Eight patients were treated with CHOP and four with a modified EPOCH regimen. One-year overall survival was 56% (95% CI 24–79%), without clear differences based on HIV status. PBL occurs in Malawi in HIV-positive and HIV-negative individuals and can be treated successfully with curative intent, even in a low-resource setting in SSA.http://link.springer.com/article/10.1186/s13027-018-0195-4Plasmablastic lymphomaHIVEBVEPOCHSub-Saharan Africa |
| spellingShingle | Takondwa Zuze Matthew S. Painschab Ryan Seguin Evarista Kudowa Bongani Kaimila Edwards Kasonkanji Tamiwe Tomoka Bal Mukunda Dhungel Maurice Mulenga Maria Chikasema Blessings Tewete Asekanadziwa Ntangwanika Sarah Chiyoyola Fred Chimzimu Coxcilly Kampani Robert Krysiak Nathan D. Montgomery Yuri Fedoriw Satish Gopal Plasmablastic lymphoma in Malawi Infectious Agents and Cancer Plasmablastic lymphoma HIV EBV EPOCH Sub-Saharan Africa |
| title | Plasmablastic lymphoma in Malawi |
| title_full | Plasmablastic lymphoma in Malawi |
| title_fullStr | Plasmablastic lymphoma in Malawi |
| title_full_unstemmed | Plasmablastic lymphoma in Malawi |
| title_short | Plasmablastic lymphoma in Malawi |
| title_sort | plasmablastic lymphoma in malawi |
| topic | Plasmablastic lymphoma HIV EBV EPOCH Sub-Saharan Africa |
| url | http://link.springer.com/article/10.1186/s13027-018-0195-4 |
| work_keys_str_mv | AT takondwazuze plasmablasticlymphomainmalawi AT matthewspainschab plasmablasticlymphomainmalawi AT ryanseguin plasmablasticlymphomainmalawi AT evaristakudowa plasmablasticlymphomainmalawi AT bonganikaimila plasmablasticlymphomainmalawi AT edwardskasonkanji plasmablasticlymphomainmalawi AT tamiwetomoka plasmablasticlymphomainmalawi AT balmukundadhungel plasmablasticlymphomainmalawi AT mauricemulenga plasmablasticlymphomainmalawi AT mariachikasema plasmablasticlymphomainmalawi AT blessingstewete plasmablasticlymphomainmalawi AT asekanadziwantangwanika plasmablasticlymphomainmalawi AT sarahchiyoyola plasmablasticlymphomainmalawi AT fredchimzimu plasmablasticlymphomainmalawi AT coxcillykampani plasmablasticlymphomainmalawi AT robertkrysiak plasmablasticlymphomainmalawi AT nathandmontgomery plasmablasticlymphomainmalawi AT yurifedoriw plasmablasticlymphomainmalawi AT satishgopal plasmablasticlymphomainmalawi |