Latissimus dorsi myocutaneous flap repair is effective after neoadjuvant chemotherapy for locally advanced breast cancer
Abstract Objective To describe the clinical outcome and physical condition of patients with locally advanced breast cancer (LABC) who received neoadjuvant chemotherapy followed by mastectomy and latissimus dorsi myocutaneous flap repair. Methods A retrospective review of 142 patients with locally ad...
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-022-02598-y |
| _version_ | 1817982324116029440 |
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| author | Lu Li Yue Yang Wang Li Xian Zhao Jia He Shuo Mei Xuejun Guo Xibin Zhang Jianghua Ran |
| author_facet | Lu Li Yue Yang Wang Li Xian Zhao Jia He Shuo Mei Xuejun Guo Xibin Zhang Jianghua Ran |
| author_sort | Lu Li |
| collection | DOAJ |
| description | Abstract Objective To describe the clinical outcome and physical condition of patients with locally advanced breast cancer (LABC) who received neoadjuvant chemotherapy followed by mastectomy and latissimus dorsi myocutaneous flap repair. Methods A retrospective review of 142 patients with locally advanced breast cancer was selected from 1156 breast cancer patients in the South and North areas of The Affiliated Calmette Hospital of Kunming Medical University between May 2008 and December 2018. Results All participants (n = 142) were women aged 40–55 years (average age 47.35 ± 0.43 years) who received neoadjuvant chemotherapy followed by mastectomy and latissimus dorsi flap repair. The median follow-up period was 16 months (range 12–24 months). For stage of disease, there were 19 cases (13%) in stage IIB, 31 cases (22%) in stage IIIA, 39 cases (28%) in stage IIIB, and 53 cases (37%) in stage IIIC, which were statistically significant with the physical condition of patients (≤ 0.001). Neoadjuvant chemotherapy was administered to shrink the tumors, and an average tumor size decrease from 10.05 ± 1.59 cm × (8.07 ± 1.54) cm to 6.11 ± 1.72 cm × (3.91 ± 1.52) cm (P < 0.001) was considered statistically significant. A t test was used for the ECOG score statistics, and the results showed that the scores were statistically significant (≤ 0.001) before and after neoadjuvant chemotherapy and after surgery. Conclusions Neoadjuvant chemotherapy is an accepted treatment option for patients with locally advanced breast cancer, and the use of a latissimus dorsi musculocutaneous flap for post-mastectomy reconstruction may improve the patients’ physical condition. Our results indicated that this strategy was safe and feasible. |
| first_indexed | 2024-04-13T23:19:22Z |
| format | Article |
| id | doaj.art-3f83f50c8fc345cb832b37a3cd7aee62 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-13T23:19:22Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-3f83f50c8fc345cb832b37a3cd7aee622022-12-22T02:25:18ZengBMCWorld Journal of Surgical Oncology1477-78192022-04-0120111010.1186/s12957-022-02598-yLatissimus dorsi myocutaneous flap repair is effective after neoadjuvant chemotherapy for locally advanced breast cancerLu Li0Yue Yang1Wang Li2Xian Zhao3Jia He4Shuo Mei5Xuejun Guo6Xibin Zhang7Jianghua Ran8Department of Breast Surgery, The Affiliated Calmette Hospital of Kunming Medical UniversityDepartment of Breast Surgery, The Affiliated Calmette Hospital of Kunming Medical UniversityDepartment of Hepatopancreatobiliary Surgery, The Affiliated Calmette Hospital of Kunming Medical UniversityDepartment of Plastic Surgery, The Affiliated Calmette Hospital of Kunming Medical UniversityDepartment of Plastic Surgery, The Affiliated Calmette Hospital of Kunming Medical UniversityDepartment of Breast Surgery, The Affiliated Calmette Hospital of Kunming Medical UniversityDepartment of Breast Surgery, The Affiliated Calmette Hospital of Kunming Medical UniversityDepartment of Hepatopancreatobiliary Surgery, The Affiliated Calmette Hospital of Kunming Medical UniversityDepartment of Hepatopancreatobiliary Surgery, The Affiliated Calmette Hospital of Kunming Medical UniversityAbstract Objective To describe the clinical outcome and physical condition of patients with locally advanced breast cancer (LABC) who received neoadjuvant chemotherapy followed by mastectomy and latissimus dorsi myocutaneous flap repair. Methods A retrospective review of 142 patients with locally advanced breast cancer was selected from 1156 breast cancer patients in the South and North areas of The Affiliated Calmette Hospital of Kunming Medical University between May 2008 and December 2018. Results All participants (n = 142) were women aged 40–55 years (average age 47.35 ± 0.43 years) who received neoadjuvant chemotherapy followed by mastectomy and latissimus dorsi flap repair. The median follow-up period was 16 months (range 12–24 months). For stage of disease, there were 19 cases (13%) in stage IIB, 31 cases (22%) in stage IIIA, 39 cases (28%) in stage IIIB, and 53 cases (37%) in stage IIIC, which were statistically significant with the physical condition of patients (≤ 0.001). Neoadjuvant chemotherapy was administered to shrink the tumors, and an average tumor size decrease from 10.05 ± 1.59 cm × (8.07 ± 1.54) cm to 6.11 ± 1.72 cm × (3.91 ± 1.52) cm (P < 0.001) was considered statistically significant. A t test was used for the ECOG score statistics, and the results showed that the scores were statistically significant (≤ 0.001) before and after neoadjuvant chemotherapy and after surgery. Conclusions Neoadjuvant chemotherapy is an accepted treatment option for patients with locally advanced breast cancer, and the use of a latissimus dorsi musculocutaneous flap for post-mastectomy reconstruction may improve the patients’ physical condition. Our results indicated that this strategy was safe and feasible.https://doi.org/10.1186/s12957-022-02598-yBreast cancerNeoadjuvant chemotherapyLatissimus dorsi musculocutaneous flapReconstructionModified radical mastectomyDefect repair |
| spellingShingle | Lu Li Yue Yang Wang Li Xian Zhao Jia He Shuo Mei Xuejun Guo Xibin Zhang Jianghua Ran Latissimus dorsi myocutaneous flap repair is effective after neoadjuvant chemotherapy for locally advanced breast cancer World Journal of Surgical Oncology Breast cancer Neoadjuvant chemotherapy Latissimus dorsi musculocutaneous flap Reconstruction Modified radical mastectomy Defect repair |
| title | Latissimus dorsi myocutaneous flap repair is effective after neoadjuvant chemotherapy for locally advanced breast cancer |
| title_full | Latissimus dorsi myocutaneous flap repair is effective after neoadjuvant chemotherapy for locally advanced breast cancer |
| title_fullStr | Latissimus dorsi myocutaneous flap repair is effective after neoadjuvant chemotherapy for locally advanced breast cancer |
| title_full_unstemmed | Latissimus dorsi myocutaneous flap repair is effective after neoadjuvant chemotherapy for locally advanced breast cancer |
| title_short | Latissimus dorsi myocutaneous flap repair is effective after neoadjuvant chemotherapy for locally advanced breast cancer |
| title_sort | latissimus dorsi myocutaneous flap repair is effective after neoadjuvant chemotherapy for locally advanced breast cancer |
| topic | Breast cancer Neoadjuvant chemotherapy Latissimus dorsi musculocutaneous flap Reconstruction Modified radical mastectomy Defect repair |
| url | https://doi.org/10.1186/s12957-022-02598-y |
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