Screening for Predictors of Chronic Ciguatera Poisoning: An Exploratory Analysis among Hospitalized Cases from French Polynesia
Ciguatera poisoning is a globally occurring seafood disease caused by the ingestion of marine products contaminated with dinoflagellate produced neurotoxins. Persistent forms of ciguatera, which prove to be highly debilitating, are poorly studied and represent a significant medical issue. The presen...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/13/9/646 |
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| author | Clémence Mahana iti Gatti Kiyojiken Chung Erwan Oehler T. J. Pierce Matthew O. Gribble Mireille Chinain |
| author_facet | Clémence Mahana iti Gatti Kiyojiken Chung Erwan Oehler T. J. Pierce Matthew O. Gribble Mireille Chinain |
| author_sort | Clémence Mahana iti Gatti |
| collection | DOAJ |
| description | Ciguatera poisoning is a globally occurring seafood disease caused by the ingestion of marine products contaminated with dinoflagellate produced neurotoxins. Persistent forms of ciguatera, which prove to be highly debilitating, are poorly studied and represent a significant medical issue. The present study aims to better understand chronic ciguatera manifestations and identify potential predictive factors for their duration. Medical files of 49 patients were analyzed, and the post-hospitalization evolution of the disease assessed through a follow-up questionnaire. A rigorous logistic lasso regression model was applied to select significant predictors from a list of 37 patient characteristics potentially predictive of having chronic symptoms. Missing data were handled by complete case analysis, and a survival analysis was implemented. All models used standardized variables, and multiple comparisons in the survival analyses were handled by Bonferroni correction. Among all studied variables, five significant predictors of having symptoms lasting ≥3 months were identified: age, tobacco consumption, acute bradycardia, laboratory measures of urea, and neutrophils. This exploratory, hypothesis-generating study contributes to the development of ciguatera epidemiology by narrowing the list from 37 possible predictors to a list of five predictors that seem worth further investigation as candidate risk factors in more targeted studies of ciguatera symptom duration. |
| first_indexed | 2024-03-10T07:09:27Z |
| format | Article |
| id | doaj.art-3f8511eda4b043a083f1c625d1a791e9 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T07:09:27Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-3f8511eda4b043a083f1c625d1a791e92023-11-22T15:31:26ZengMDPI AGToxins2072-66512021-09-0113964610.3390/toxins13090646Screening for Predictors of Chronic Ciguatera Poisoning: An Exploratory Analysis among Hospitalized Cases from French PolynesiaClémence Mahana iti Gatti0Kiyojiken Chung1Erwan Oehler2T. J. Pierce3Matthew O. Gribble4Mireille Chinain5Laboratory of Marine Biotoxins, Institut Louis Malardé (ILM), UMR 241-EIO (IFREMER, ILM, IRD, Univ. Polynésie Française), Papeete, Tahiti 98713, French PolynesiaLaboratory of Marine Biotoxins, Institut Louis Malardé (ILM), UMR 241-EIO (IFREMER, ILM, IRD, Univ. Polynésie Française), Papeete, Tahiti 98713, French PolynesiaCentre Hospitalier de Polynésie française, Papeete, Tahiti 98713, French PolynesiaGangarosa Department of Environmental Health, Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA 30322, USADepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35233, USALaboratory of Marine Biotoxins, Institut Louis Malardé (ILM), UMR 241-EIO (IFREMER, ILM, IRD, Univ. Polynésie Française), Papeete, Tahiti 98713, French PolynesiaCiguatera poisoning is a globally occurring seafood disease caused by the ingestion of marine products contaminated with dinoflagellate produced neurotoxins. Persistent forms of ciguatera, which prove to be highly debilitating, are poorly studied and represent a significant medical issue. The present study aims to better understand chronic ciguatera manifestations and identify potential predictive factors for their duration. Medical files of 49 patients were analyzed, and the post-hospitalization evolution of the disease assessed through a follow-up questionnaire. A rigorous logistic lasso regression model was applied to select significant predictors from a list of 37 patient characteristics potentially predictive of having chronic symptoms. Missing data were handled by complete case analysis, and a survival analysis was implemented. All models used standardized variables, and multiple comparisons in the survival analyses were handled by Bonferroni correction. Among all studied variables, five significant predictors of having symptoms lasting ≥3 months were identified: age, tobacco consumption, acute bradycardia, laboratory measures of urea, and neutrophils. This exploratory, hypothesis-generating study contributes to the development of ciguatera epidemiology by narrowing the list from 37 possible predictors to a list of five predictors that seem worth further investigation as candidate risk factors in more targeted studies of ciguatera symptom duration.https://www.mdpi.com/2072-6651/13/9/646ciguatera poisoningepidemiologyleast absolute shrinkage and selection operatormachine learningdata sciencemedical informatics |
| spellingShingle | Clémence Mahana iti Gatti Kiyojiken Chung Erwan Oehler T. J. Pierce Matthew O. Gribble Mireille Chinain Screening for Predictors of Chronic Ciguatera Poisoning: An Exploratory Analysis among Hospitalized Cases from French Polynesia Toxins ciguatera poisoning epidemiology least absolute shrinkage and selection operator machine learning data science medical informatics |
| title | Screening for Predictors of Chronic Ciguatera Poisoning: An Exploratory Analysis among Hospitalized Cases from French Polynesia |
| title_full | Screening for Predictors of Chronic Ciguatera Poisoning: An Exploratory Analysis among Hospitalized Cases from French Polynesia |
| title_fullStr | Screening for Predictors of Chronic Ciguatera Poisoning: An Exploratory Analysis among Hospitalized Cases from French Polynesia |
| title_full_unstemmed | Screening for Predictors of Chronic Ciguatera Poisoning: An Exploratory Analysis among Hospitalized Cases from French Polynesia |
| title_short | Screening for Predictors of Chronic Ciguatera Poisoning: An Exploratory Analysis among Hospitalized Cases from French Polynesia |
| title_sort | screening for predictors of chronic ciguatera poisoning an exploratory analysis among hospitalized cases from french polynesia |
| topic | ciguatera poisoning epidemiology least absolute shrinkage and selection operator machine learning data science medical informatics |
| url | https://www.mdpi.com/2072-6651/13/9/646 |
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