Umbilical Cord Serum Lipid Profile of Normal Preterm Neonates and Preterm Neonates with Respiratory Distress Syndrome: A Hospital-based Cross-sectional Study
Introduction: Respiratory Distress Syndrome (RDS) is a common cause of morbidity and mortality in preterm neonates. Levels of minor phospholipids and lecithin in amniotic fluid are significantly influenced by lipid metabolism. Aim: To evaluate umbilical cord lipid profile of preterm infants with R...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Pvt. Ltd.
2020-10-01
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| Series: | Indian Journal of Neonatal Medicine and Research |
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| Online Access: | http://www.ijnmr.net/articles/PDF/2282/45965_CE[Ra]_F(Sh)_PF1(AD_OM)_PN(SHU).pdf |
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| author | Ram Narain Sehra Ankush Gar Suniti Verma |
| author_facet | Ram Narain Sehra Ankush Gar Suniti Verma |
| author_sort | Ram Narain Sehra |
| collection | DOAJ |
| description | Introduction: Respiratory Distress Syndrome (RDS) is a common cause of morbidity and mortality in preterm neonates. Levels of minor phospholipids and lecithin in amniotic fluid are significantly influenced by lipid metabolism.
Aim: To evaluate umbilical cord lipid profile of preterm infants with RDS and normal preterm group without RDS.
Materials and Methods: This was a hospital-based crosssectional study carried out in neonatal unit of at a Tertiary Care Centre at SMS Medical College, Jaipur, from June 2017 to May 2018. Out of total 80 preterm infants, 40 developed RDS and 40 infants served as controls. Umbilical cord blood lipid profile of neonates were done in both the groups and compared. Chi-Square test and unpaired Student’s t-test were used for statistical analysis. Probability was considered significant if less than 0.05
Results: Mean weight of babies was 1494.75±201.66 grams in normal preterm group and 1450.25±233.23 grams in preterm with RDS group (p=0.364). Mean gestational age was 31.45±1.36 weeks in normal preterm group and 30.98±1.49 weeks in preterm with RDS group p=0.140). Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL) were higher in male babies in both the groups as compared to female babies (p>0.05). Mean cord blood Triglyceride (TG), Total Cholesterol (TC), Very Low Density Lipoprotein (VLDL), LDL and HDL levels were significantly lower in preterms with RDS as compared to normal preterms without RDS which was statistically significant (p <0.05). Mean cord blood TG, TC, VLDL and HDL levels in all gestational age were higher in normal preterm as compared to preterm with RDS (p <0.05), except for LDL on 34-36 weeks age.
Conclusion: Preterm newborns with lower cord serum lipids may develop RDS. The cord blood, which is easily available, can be used for lipid levels at birth to predict RDS. |
| first_indexed | 2024-12-20T17:11:25Z |
| format | Article |
| id | doaj.art-3f85b2cdd3b2477cb92b4f927d882733 |
| institution | Directory Open Access Journal |
| issn | 2277-8527 2455-6890 |
| language | English |
| last_indexed | 2024-12-20T17:11:25Z |
| publishDate | 2020-10-01 |
| publisher | JCDR Research and Publications Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Neonatal Medicine and Research |
| spelling | doaj.art-3f85b2cdd3b2477cb92b4f927d8827332022-12-21T19:32:07ZengJCDR Research and Publications Pvt. Ltd.Indian Journal of Neonatal Medicine and Research2277-85272455-68902020-10-0184343810.7860/IJNMR/2020/45965.2282Umbilical Cord Serum Lipid Profile of Normal Preterm Neonates and Preterm Neonates with Respiratory Distress Syndrome: A Hospital-based Cross-sectional StudyRam Narain SehraAnkush GarSuniti VermaIntroduction: Respiratory Distress Syndrome (RDS) is a common cause of morbidity and mortality in preterm neonates. Levels of minor phospholipids and lecithin in amniotic fluid are significantly influenced by lipid metabolism. Aim: To evaluate umbilical cord lipid profile of preterm infants with RDS and normal preterm group without RDS. Materials and Methods: This was a hospital-based crosssectional study carried out in neonatal unit of at a Tertiary Care Centre at SMS Medical College, Jaipur, from June 2017 to May 2018. Out of total 80 preterm infants, 40 developed RDS and 40 infants served as controls. Umbilical cord blood lipid profile of neonates were done in both the groups and compared. Chi-Square test and unpaired Student’s t-test were used for statistical analysis. Probability was considered significant if less than 0.05 Results: Mean weight of babies was 1494.75±201.66 grams in normal preterm group and 1450.25±233.23 grams in preterm with RDS group (p=0.364). Mean gestational age was 31.45±1.36 weeks in normal preterm group and 30.98±1.49 weeks in preterm with RDS group p=0.140). Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL) were higher in male babies in both the groups as compared to female babies (p>0.05). Mean cord blood Triglyceride (TG), Total Cholesterol (TC), Very Low Density Lipoprotein (VLDL), LDL and HDL levels were significantly lower in preterms with RDS as compared to normal preterms without RDS which was statistically significant (p <0.05). Mean cord blood TG, TC, VLDL and HDL levels in all gestational age were higher in normal preterm as compared to preterm with RDS (p <0.05), except for LDL on 34-36 weeks age. Conclusion: Preterm newborns with lower cord serum lipids may develop RDS. The cord blood, which is easily available, can be used for lipid levels at birth to predict RDS.http://www.ijnmr.net/articles/PDF/2282/45965_CE[Ra]_F(Sh)_PF1(AD_OM)_PN(SHU).pdfprematurityrespirationumbilical cord |
| spellingShingle | Ram Narain Sehra Ankush Gar Suniti Verma Umbilical Cord Serum Lipid Profile of Normal Preterm Neonates and Preterm Neonates with Respiratory Distress Syndrome: A Hospital-based Cross-sectional Study Indian Journal of Neonatal Medicine and Research prematurity respiration umbilical cord |
| title | Umbilical Cord Serum Lipid Profile of Normal Preterm Neonates and Preterm Neonates with Respiratory Distress Syndrome: A Hospital-based Cross-sectional Study |
| title_full | Umbilical Cord Serum Lipid Profile of Normal Preterm Neonates and Preterm Neonates with Respiratory Distress Syndrome: A Hospital-based Cross-sectional Study |
| title_fullStr | Umbilical Cord Serum Lipid Profile of Normal Preterm Neonates and Preterm Neonates with Respiratory Distress Syndrome: A Hospital-based Cross-sectional Study |
| title_full_unstemmed | Umbilical Cord Serum Lipid Profile of Normal Preterm Neonates and Preterm Neonates with Respiratory Distress Syndrome: A Hospital-based Cross-sectional Study |
| title_short | Umbilical Cord Serum Lipid Profile of Normal Preterm Neonates and Preterm Neonates with Respiratory Distress Syndrome: A Hospital-based Cross-sectional Study |
| title_sort | umbilical cord serum lipid profile of normal preterm neonates and preterm neonates with respiratory distress syndrome a hospital based cross sectional study |
| topic | prematurity respiration umbilical cord |
| url | http://www.ijnmr.net/articles/PDF/2282/45965_CE[Ra]_F(Sh)_PF1(AD_OM)_PN(SHU).pdf |
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