The Affect of Preoperative Neutrophil-Lymphocyte Ratio on Distant Metastasis and Disease Specific Survival in Patients Who Underwent Nephrectomy for Localized Renal Cell Carcinoma
INTRODUCTION: In this study, we aimed to evaluate the effects of pre-nephrectomy Neutrophil-Lymphocyte ratio (NLR) on development of distant metastasis and disease specific survival (DSS). METHODS: The data of 780 patients who underwent radical or partial nephrectomy for localized renal cell carcino...
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| Format: | Article |
| Language: | English |
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Van Yuzuncu Yil University, School of Medicine
2017-07-01
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| Series: | Van Tıp Dergisi |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-29591 |
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| author | Nurullah Hamidi Evren Süer Mehmet İlker Gökçe Yaşar Bedük |
| author_facet | Nurullah Hamidi Evren Süer Mehmet İlker Gökçe Yaşar Bedük |
| author_sort | Nurullah Hamidi |
| collection | DOAJ |
| description | INTRODUCTION: In this study, we aimed to evaluate the effects of pre-nephrectomy Neutrophil-Lymphocyte ratio (NLR) on development of distant metastasis and disease specific survival (DSS). METHODS: The data of 780 patients who underwent radical or partial nephrectomy for localized renal cell carcinoma (RCC) between January 1995 and December 2014 was evaluated retrospectively. The demographics, pathologic stage, histological type of tumor, tumor grade were recorded. Furthermore, data of white blood cell, platelet, neutrophil, lymphocyte counts and NLR (level within 14 days before nephrectomy) were recorded. Primary endpoints of this study were distant metastasis development and DSS. RESULTS: For all patients mean age was 58.4+-12. During median 44 months follow-up period, distant metastasis developed in 210 (26.9%) patients and death occurred due to RCC in 132 (16.9%) patients. High NLR levels (NLR≥4) were related to higher Fuhrmann tumor grade, advanced tumor stage, distant metastasis development and disease specific mortality (for all comparisons p<0.001). On multivariate analysis, Fuhrmann tumor grade 3-4, pathological stage 3-4 and NLR≥4 were found as independent predictive factor to predict metastasis development. To predict DSS, pathological stage 3-4 and NLR≥4 were found as independent predictive factor. DISCUSSION AND CONCLUSION: High NLR associated with high risk of metastasis development and DSS. However, multicenter and prospective trials are needed to support our results. |
| first_indexed | 2024-03-09T08:26:30Z |
| format | Article |
| id | doaj.art-3f874f6b4451441eb78523d542692792 |
| institution | Directory Open Access Journal |
| issn | 2587-0351 |
| language | English |
| last_indexed | 2024-03-09T08:26:30Z |
| publishDate | 2017-07-01 |
| publisher | Van Yuzuncu Yil University, School of Medicine |
| record_format | Article |
| series | Van Tıp Dergisi |
| spelling | doaj.art-3f874f6b4451441eb78523d5426927922023-12-02T21:08:29ZengVan Yuzuncu Yil University, School of MedicineVan Tıp Dergisi2587-03512017-07-0124313514010.5505/vtd.2017.29591VTD-29591The Affect of Preoperative Neutrophil-Lymphocyte Ratio on Distant Metastasis and Disease Specific Survival in Patients Who Underwent Nephrectomy for Localized Renal Cell CarcinomaNurullah Hamidi0Evren Süer1Mehmet İlker Gökçe2Yaşar Bedük3Department of Urology, Ankara University, Ankara, TurkeyDepartment of Urology, Ankara University, Ankara, TurkeyDepartment of Urology, Ankara University, Ankara, TurkeyDepartment of Urology, Ankara University, Ankara, TurkeyINTRODUCTION: In this study, we aimed to evaluate the effects of pre-nephrectomy Neutrophil-Lymphocyte ratio (NLR) on development of distant metastasis and disease specific survival (DSS). METHODS: The data of 780 patients who underwent radical or partial nephrectomy for localized renal cell carcinoma (RCC) between January 1995 and December 2014 was evaluated retrospectively. The demographics, pathologic stage, histological type of tumor, tumor grade were recorded. Furthermore, data of white blood cell, platelet, neutrophil, lymphocyte counts and NLR (level within 14 days before nephrectomy) were recorded. Primary endpoints of this study were distant metastasis development and DSS. RESULTS: For all patients mean age was 58.4+-12. During median 44 months follow-up period, distant metastasis developed in 210 (26.9%) patients and death occurred due to RCC in 132 (16.9%) patients. High NLR levels (NLR≥4) were related to higher Fuhrmann tumor grade, advanced tumor stage, distant metastasis development and disease specific mortality (for all comparisons p<0.001). On multivariate analysis, Fuhrmann tumor grade 3-4, pathological stage 3-4 and NLR≥4 were found as independent predictive factor to predict metastasis development. To predict DSS, pathological stage 3-4 and NLR≥4 were found as independent predictive factor. DISCUSSION AND CONCLUSION: High NLR associated with high risk of metastasis development and DSS. However, multicenter and prospective trials are needed to support our results.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-29591kidney tumormetastasisneutrophil-lymphocyte ratiosurvival |
| spellingShingle | Nurullah Hamidi Evren Süer Mehmet İlker Gökçe Yaşar Bedük The Affect of Preoperative Neutrophil-Lymphocyte Ratio on Distant Metastasis and Disease Specific Survival in Patients Who Underwent Nephrectomy for Localized Renal Cell Carcinoma Van Tıp Dergisi kidney tumor metastasis neutrophil-lymphocyte ratio survival |
| title | The Affect of Preoperative Neutrophil-Lymphocyte Ratio on Distant Metastasis and Disease Specific Survival in Patients Who Underwent Nephrectomy for Localized Renal Cell Carcinoma |
| title_full | The Affect of Preoperative Neutrophil-Lymphocyte Ratio on Distant Metastasis and Disease Specific Survival in Patients Who Underwent Nephrectomy for Localized Renal Cell Carcinoma |
| title_fullStr | The Affect of Preoperative Neutrophil-Lymphocyte Ratio on Distant Metastasis and Disease Specific Survival in Patients Who Underwent Nephrectomy for Localized Renal Cell Carcinoma |
| title_full_unstemmed | The Affect of Preoperative Neutrophil-Lymphocyte Ratio on Distant Metastasis and Disease Specific Survival in Patients Who Underwent Nephrectomy for Localized Renal Cell Carcinoma |
| title_short | The Affect of Preoperative Neutrophil-Lymphocyte Ratio on Distant Metastasis and Disease Specific Survival in Patients Who Underwent Nephrectomy for Localized Renal Cell Carcinoma |
| title_sort | affect of preoperative neutrophil lymphocyte ratio on distant metastasis and disease specific survival in patients who underwent nephrectomy for localized renal cell carcinoma |
| topic | kidney tumor metastasis neutrophil-lymphocyte ratio survival |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-29591 |
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