A Predictive Nomogram for Lymph Node Metastasis in Supraglottic Laryngeal Squamous Cell Carcinoma
PurposeLymph node metastasis (LNM) has a negative impact on the survival of patients with laryngeal squamous cell carcinoma (LSCC). Supraglottic LSCC is the most common cause of cervical lymph node metastases due to the extensive submucosal lymphatic plexus. The accurate evaluation of LNM before sur...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.786207/full |
| _version_ | 1828751211889688576 |
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| author | Lulu Song Yu Heng Chi-Yao Hsueh Huiying Huang Lei Tao Liang Zhou Ming Zhang |
| author_facet | Lulu Song Yu Heng Chi-Yao Hsueh Huiying Huang Lei Tao Liang Zhou Ming Zhang |
| author_sort | Lulu Song |
| collection | DOAJ |
| description | PurposeLymph node metastasis (LNM) has a negative impact on the survival of patients with laryngeal squamous cell carcinoma (LSCC). Supraglottic LSCC is the most common cause of cervical lymph node metastases due to the extensive submucosal lymphatic plexus. The accurate evaluation of LNM before surgery can inform improved decisions in the clinic. In this study, we aimed to construct a nomogram to predict LNM in primary supraglottic LSCC patients.MethodsThe data from 314 patients with clinico-pathological confirmed supraglottic LSCC who underwent partial or total laryngectomy in our department from 2016 to 2020 were retrospectively analyzed (243 cases in the training set and 71 cases in the validation set). A multivariate logistic regression model was used to screen out independent risk factors and a nomogram was established. The accuracy and discrimination ability of the nomogram was evaluated using a consistency index and calibration curves.ResultsTumor size, tumor differentiation degree and LMR (lymphocyte-monocyte ratio) were selected to construct the nomogram. The C-index was 0.731 in the training set and 0.707 in the validation set. The calibration curves of the training and validation group both exhibited close agreement between the predicted and the actual presence of LNM.ConclusionsA nomogram was established based on routinely measured pretreatment variables and the predicted results improved the management of patients with LNM. |
| first_indexed | 2024-12-10T20:50:04Z |
| format | Article |
| id | doaj.art-3f8854c5c9df48138e253f3d7f2e281a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-10T20:50:04Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-3f8854c5c9df48138e253f3d7f2e281a2022-12-22T01:34:07ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-03-011210.3389/fonc.2022.786207786207A Predictive Nomogram for Lymph Node Metastasis in Supraglottic Laryngeal Squamous Cell CarcinomaLulu SongYu HengChi-Yao HsuehHuiying HuangLei TaoLiang ZhouMing ZhangPurposeLymph node metastasis (LNM) has a negative impact on the survival of patients with laryngeal squamous cell carcinoma (LSCC). Supraglottic LSCC is the most common cause of cervical lymph node metastases due to the extensive submucosal lymphatic plexus. The accurate evaluation of LNM before surgery can inform improved decisions in the clinic. In this study, we aimed to construct a nomogram to predict LNM in primary supraglottic LSCC patients.MethodsThe data from 314 patients with clinico-pathological confirmed supraglottic LSCC who underwent partial or total laryngectomy in our department from 2016 to 2020 were retrospectively analyzed (243 cases in the training set and 71 cases in the validation set). A multivariate logistic regression model was used to screen out independent risk factors and a nomogram was established. The accuracy and discrimination ability of the nomogram was evaluated using a consistency index and calibration curves.ResultsTumor size, tumor differentiation degree and LMR (lymphocyte-monocyte ratio) were selected to construct the nomogram. The C-index was 0.731 in the training set and 0.707 in the validation set. The calibration curves of the training and validation group both exhibited close agreement between the predicted and the actual presence of LNM.ConclusionsA nomogram was established based on routinely measured pretreatment variables and the predicted results improved the management of patients with LNM.https://www.frontiersin.org/articles/10.3389/fonc.2022.786207/fullsupraglottic squamous cell laryngeal cancerlymph node metastasisnomogramdiagnosisC-index |
| spellingShingle | Lulu Song Yu Heng Chi-Yao Hsueh Huiying Huang Lei Tao Liang Zhou Ming Zhang A Predictive Nomogram for Lymph Node Metastasis in Supraglottic Laryngeal Squamous Cell Carcinoma Frontiers in Oncology supraglottic squamous cell laryngeal cancer lymph node metastasis nomogram diagnosis C-index |
| title | A Predictive Nomogram for Lymph Node Metastasis in Supraglottic Laryngeal Squamous Cell Carcinoma |
| title_full | A Predictive Nomogram for Lymph Node Metastasis in Supraglottic Laryngeal Squamous Cell Carcinoma |
| title_fullStr | A Predictive Nomogram for Lymph Node Metastasis in Supraglottic Laryngeal Squamous Cell Carcinoma |
| title_full_unstemmed | A Predictive Nomogram for Lymph Node Metastasis in Supraglottic Laryngeal Squamous Cell Carcinoma |
| title_short | A Predictive Nomogram for Lymph Node Metastasis in Supraglottic Laryngeal Squamous Cell Carcinoma |
| title_sort | predictive nomogram for lymph node metastasis in supraglottic laryngeal squamous cell carcinoma |
| topic | supraglottic squamous cell laryngeal cancer lymph node metastasis nomogram diagnosis C-index |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.786207/full |
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