Will metformin use lead to a decreased risk of thyroid cancer? A systematic review and meta-analyses
Abstract Background It has been reported that metformin use may reduce the risk of thyroid cancer, but existing studies have generated inconsistent results. The purpose of this study was to investigate such association between metformin use and the risk of thyroid cancer. Methods Studies of metformi...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-09-01
|
| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01287-0 |
| _version_ | 1797453468361818112 |
|---|---|
| author | Hailong Li Yue Chen Lei Hu Wenzhi Yang Zongshi Gao Mengqing Liu Hui Tao Jie Li |
| author_facet | Hailong Li Yue Chen Lei Hu Wenzhi Yang Zongshi Gao Mengqing Liu Hui Tao Jie Li |
| author_sort | Hailong Li |
| collection | DOAJ |
| description | Abstract Background It has been reported that metformin use may reduce the risk of thyroid cancer, but existing studies have generated inconsistent results. The purpose of this study was to investigate such association between metformin use and the risk of thyroid cancer. Methods Studies of metformin use for the risk of thyroid cancer were searched in Web of Science, PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, China Biomedical Database, Wanfang Data, and Chinese Scientific Journals Database (VIP) from the establishment date to December 2022. Newcastle–Ottawa scale is adopted for assessing the methodological quality of included studies, and the inter-study heterogeneity was assessed by using the I-squared statistic. Combined odds ratios (ORs) with the corresponding 95% confidence intervals (CIs) were calculated through either fixed-effects or random-effects model according to the heterogeneity. Besides, subgroup analyses, sensitivity analyses and test for publication bias were conducted. Results Five studies involving 1,713,528 participants were enrolled in the qualitative and quantitative synthesis. The result of the meta-analyses showed that metformin use was associated with a statistically significant lower risk of thyroid cancer (pooled OR = 0.68, 95% CI = 0.50–0.91, P = 0.011). Moreover, in the subgroup analysis, we found that the use of metformin may also aid in the prevention of thyroid cancer in Eastern population (pooled OR = 0.55, 95% CI = 0.35–0.88, P = 0.012) rather than Western population (pooled OR = 0.89, 95% CI = 0.52–1.54, P = 0.685). Sensitivity analysis suggested the results of this meta-analyses were relatively stable. No publication bias was detected. Conclusion Metformin use is beneficial for reducing the risk of thyroid cancer. For further investigation, more well-designed studies are still needed to elucidate the association between metformin use and the risk of thyroid cancer. |
| first_indexed | 2024-03-09T15:23:16Z |
| format | Article |
| id | doaj.art-3f8938b19b8a43e896d5ca0905a3d617 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-09T15:23:16Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-3f8938b19b8a43e896d5ca0905a3d6172023-11-26T12:41:47ZengBMCEuropean Journal of Medical Research2047-783X2023-09-0128111210.1186/s40001-023-01287-0Will metformin use lead to a decreased risk of thyroid cancer? A systematic review and meta-analysesHailong Li0Yue Chen1Lei Hu2Wenzhi Yang3Zongshi Gao4Mengqing Liu5Hui Tao6Jie Li7Department of Clinical Medicine, Sun Yat-Sen UniversityDepartment of Orthopedics, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Orthopedics, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Orthopedics, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Orthopedics, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Clinical Medicine, School of Chaohu Clinical Medicine, Anhui Medical UniversityDepartment of Orthopedics, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical UniversityAbstract Background It has been reported that metformin use may reduce the risk of thyroid cancer, but existing studies have generated inconsistent results. The purpose of this study was to investigate such association between metformin use and the risk of thyroid cancer. Methods Studies of metformin use for the risk of thyroid cancer were searched in Web of Science, PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, China Biomedical Database, Wanfang Data, and Chinese Scientific Journals Database (VIP) from the establishment date to December 2022. Newcastle–Ottawa scale is adopted for assessing the methodological quality of included studies, and the inter-study heterogeneity was assessed by using the I-squared statistic. Combined odds ratios (ORs) with the corresponding 95% confidence intervals (CIs) were calculated through either fixed-effects or random-effects model according to the heterogeneity. Besides, subgroup analyses, sensitivity analyses and test for publication bias were conducted. Results Five studies involving 1,713,528 participants were enrolled in the qualitative and quantitative synthesis. The result of the meta-analyses showed that metformin use was associated with a statistically significant lower risk of thyroid cancer (pooled OR = 0.68, 95% CI = 0.50–0.91, P = 0.011). Moreover, in the subgroup analysis, we found that the use of metformin may also aid in the prevention of thyroid cancer in Eastern population (pooled OR = 0.55, 95% CI = 0.35–0.88, P = 0.012) rather than Western population (pooled OR = 0.89, 95% CI = 0.52–1.54, P = 0.685). Sensitivity analysis suggested the results of this meta-analyses were relatively stable. No publication bias was detected. Conclusion Metformin use is beneficial for reducing the risk of thyroid cancer. For further investigation, more well-designed studies are still needed to elucidate the association between metformin use and the risk of thyroid cancer.https://doi.org/10.1186/s40001-023-01287-0Metformin useThyroid cancerSystematic reviewMeta-analyses |
| spellingShingle | Hailong Li Yue Chen Lei Hu Wenzhi Yang Zongshi Gao Mengqing Liu Hui Tao Jie Li Will metformin use lead to a decreased risk of thyroid cancer? A systematic review and meta-analyses European Journal of Medical Research Metformin use Thyroid cancer Systematic review Meta-analyses |
| title | Will metformin use lead to a decreased risk of thyroid cancer? A systematic review and meta-analyses |
| title_full | Will metformin use lead to a decreased risk of thyroid cancer? A systematic review and meta-analyses |
| title_fullStr | Will metformin use lead to a decreased risk of thyroid cancer? A systematic review and meta-analyses |
| title_full_unstemmed | Will metformin use lead to a decreased risk of thyroid cancer? A systematic review and meta-analyses |
| title_short | Will metformin use lead to a decreased risk of thyroid cancer? A systematic review and meta-analyses |
| title_sort | will metformin use lead to a decreased risk of thyroid cancer a systematic review and meta analyses |
| topic | Metformin use Thyroid cancer Systematic review Meta-analyses |
| url | https://doi.org/10.1186/s40001-023-01287-0 |
| work_keys_str_mv | AT hailongli willmetforminuseleadtoadecreasedriskofthyroidcancerasystematicreviewandmetaanalyses AT yuechen willmetforminuseleadtoadecreasedriskofthyroidcancerasystematicreviewandmetaanalyses AT leihu willmetforminuseleadtoadecreasedriskofthyroidcancerasystematicreviewandmetaanalyses AT wenzhiyang willmetforminuseleadtoadecreasedriskofthyroidcancerasystematicreviewandmetaanalyses AT zongshigao willmetforminuseleadtoadecreasedriskofthyroidcancerasystematicreviewandmetaanalyses AT mengqingliu willmetforminuseleadtoadecreasedriskofthyroidcancerasystematicreviewandmetaanalyses AT huitao willmetforminuseleadtoadecreasedriskofthyroidcancerasystematicreviewandmetaanalyses AT jieli willmetforminuseleadtoadecreasedriskofthyroidcancerasystematicreviewandmetaanalyses |