Severity evaluation of bhronic polypous rhinosinusitis based on changes of IL-1β cytokine and IL-1ra concentrations in nasal secretions
We provide the data on distribution of IL-1β and IL-1ra cytokine concentrations in nasal secretions from the patients with different forms of chronic polypous rhinosinusitis. The control group (group 1) included healthy persons. The second group consisted of patients exhibiting chronic polypous rhin...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2020-01-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/1742 |
| _version_ | 1797197872878321664 |
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| author | E. V. Bezrukova E. V. Vorobeychikov V. G. Konusova A. S. Simbirtsev |
| author_facet | E. V. Bezrukova E. V. Vorobeychikov V. G. Konusova A. S. Simbirtsev |
| author_sort | E. V. Bezrukova |
| collection | DOAJ |
| description | We provide the data on distribution of IL-1β and IL-1ra cytokine concentrations in nasal secretions from the patients with different forms of chronic polypous rhinosinusitis. The control group (group 1) included healthy persons. The second group consisted of patients exhibiting chronic polypous rhinosinusitis (CRS-NP), free of clinical signs of purulent inflammation in paranasal sinuses and/or bronchial asthma. The patients of group 3 were diagnosed with chronic purulent polypous rhinosinusitis (CPRS-NP). Group 4 consisted of the patients with chronic polypoid rhinosinusitis complicated by bronchial asthma (CRS-NP + BA). Cytokine concentration was determined by means of ELISA tests for all the patient groups. We have found that the local concentrations of IL-1ra and IL-1β cytokines were significantly different (p < 0.05) from the group of healthy individuals, dependent on the clinical forms of chronic polyposis. IL-1β concentrations in the group of patients with CRS-NP (No. 2) were increased 5-fold, for group of CPRS-NP patients (No. 3), these levels showed a 15.5-fold increase. In the group of patients with CRS-NP + BA (No. 4), the Il-1 levels were 13fold higher in comparison with healthy controls. The IL-1ra concentration in the group of healthy people (No. 1) was 1825.64+463.70 pg/ml. Upon development of CRS-NP (No. 2), an increase in its values up to 3646.21±263.39 pg/ml was registered. Upon development of CPRS-NP (No. 3), an increase in appropriate values up to 2305.33±282.86 pg/ml was noted, and, in cases of CRS-NP + BA, a decrease in its values to 956.15±213.02 pg/ml was observed.Meanwhile, a conflicting character was revealed for the changes in these cytokines, thus preventing their usage as an indicator of polyposis severity. At the same time, estimation of the CIL-1ra/CIL- 1β ratio in nasal secretions of the patients in groups 1, 2, 3 and 4 based on two-dimensional projection of the spatial CIL-1ra/ CIL-1β distribution provides a basis for discrimination of the patient groups. The CIL-1ra/ CIL-1β ratio as assessed for nasal secretions of patients belonging to groups 1, 2, 3, and 4 shows a general, statistically significant decrease with increasing severity of chronic polyposis (p < 0.001), thus making this parameter indiformative for intensity of the pathological process. The resulting 95% confidence intervals confirm that the cytokine ratios are promising parameter in order to estimate the efficiency of immune therapy. |
| first_indexed | 2024-03-08T05:48:34Z |
| format | Article |
| id | doaj.art-3f89fa194ded492bb1cbe05d6359285f |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:50:52Z |
| publishDate | 2020-01-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-3f89fa194ded492bb1cbe05d6359285f2024-04-22T13:07:45ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2020-01-012161155116210.15789/1563-0625-2019-6-1155-11621235Severity evaluation of bhronic polypous rhinosinusitis based on changes of IL-1β cytokine and IL-1ra concentrations in nasal secretionsE. V. Bezrukova0E. V. Vorobeychikov1V. G. Konusova2A. S. Simbirtsev3North-Western State I. Mechnikov Medical UniversityPolifarm LLCPolifarm LLCState Research Institute of Highly Pure BiopreparationsWe provide the data on distribution of IL-1β and IL-1ra cytokine concentrations in nasal secretions from the patients with different forms of chronic polypous rhinosinusitis. The control group (group 1) included healthy persons. The second group consisted of patients exhibiting chronic polypous rhinosinusitis (CRS-NP), free of clinical signs of purulent inflammation in paranasal sinuses and/or bronchial asthma. The patients of group 3 were diagnosed with chronic purulent polypous rhinosinusitis (CPRS-NP). Group 4 consisted of the patients with chronic polypoid rhinosinusitis complicated by bronchial asthma (CRS-NP + BA). Cytokine concentration was determined by means of ELISA tests for all the patient groups. We have found that the local concentrations of IL-1ra and IL-1β cytokines were significantly different (p < 0.05) from the group of healthy individuals, dependent on the clinical forms of chronic polyposis. IL-1β concentrations in the group of patients with CRS-NP (No. 2) were increased 5-fold, for group of CPRS-NP patients (No. 3), these levels showed a 15.5-fold increase. In the group of patients with CRS-NP + BA (No. 4), the Il-1 levels were 13fold higher in comparison with healthy controls. The IL-1ra concentration in the group of healthy people (No. 1) was 1825.64+463.70 pg/ml. Upon development of CRS-NP (No. 2), an increase in its values up to 3646.21±263.39 pg/ml was registered. Upon development of CPRS-NP (No. 3), an increase in appropriate values up to 2305.33±282.86 pg/ml was noted, and, in cases of CRS-NP + BA, a decrease in its values to 956.15±213.02 pg/ml was observed.Meanwhile, a conflicting character was revealed for the changes in these cytokines, thus preventing their usage as an indicator of polyposis severity. At the same time, estimation of the CIL-1ra/CIL- 1β ratio in nasal secretions of the patients in groups 1, 2, 3 and 4 based on two-dimensional projection of the spatial CIL-1ra/ CIL-1β distribution provides a basis for discrimination of the patient groups. The CIL-1ra/ CIL-1β ratio as assessed for nasal secretions of patients belonging to groups 1, 2, 3, and 4 shows a general, statistically significant decrease with increasing severity of chronic polyposis (p < 0.001), thus making this parameter indiformative for intensity of the pathological process. The resulting 95% confidence intervals confirm that the cytokine ratios are promising parameter in order to estimate the efficiency of immune therapy.https://www.mimmun.ru/mimmun/article/view/1742chronic rhinosinusitisnasal polyposisil-1βil-1racytokineschronic rhinosinusitisinterleukins |
| spellingShingle | E. V. Bezrukova E. V. Vorobeychikov V. G. Konusova A. S. Simbirtsev Severity evaluation of bhronic polypous rhinosinusitis based on changes of IL-1β cytokine and IL-1ra concentrations in nasal secretions Медицинская иммунология chronic rhinosinusitis nasal polyposis il-1β il-1ra cytokines chronic rhinosinusitis interleukins |
| title | Severity evaluation of bhronic polypous rhinosinusitis based on changes of IL-1β cytokine and IL-1ra concentrations in nasal secretions |
| title_full | Severity evaluation of bhronic polypous rhinosinusitis based on changes of IL-1β cytokine and IL-1ra concentrations in nasal secretions |
| title_fullStr | Severity evaluation of bhronic polypous rhinosinusitis based on changes of IL-1β cytokine and IL-1ra concentrations in nasal secretions |
| title_full_unstemmed | Severity evaluation of bhronic polypous rhinosinusitis based on changes of IL-1β cytokine and IL-1ra concentrations in nasal secretions |
| title_short | Severity evaluation of bhronic polypous rhinosinusitis based on changes of IL-1β cytokine and IL-1ra concentrations in nasal secretions |
| title_sort | severity evaluation of bhronic polypous rhinosinusitis based on changes of il 1β cytokine and il 1ra concentrations in nasal secretions |
| topic | chronic rhinosinusitis nasal polyposis il-1β il-1ra cytokines chronic rhinosinusitis interleukins |
| url | https://www.mimmun.ru/mimmun/article/view/1742 |
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