Associations between lower extremity muscle mass and metabolic parameters related to obesity in Japanese obese patients with type 2 diabetes
Background. Age-related loss of muscle mass (sarcopenia) increases the incidence of obesity in the elderly by reducing physical activity. This sarcopenic obesity may become self-perpetuating, increasing the risks for metabolic syndrome, disability, and mortality. We investigated the associations of...
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PeerJ Inc.
2015-05-01
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| author | Hidetaka Hamasaki Yu Kawashima Hiroki Adachi Sumie Moriyama Hisayuki Katsuyama Akahito Sako Hidekatsu Yanai |
| author_facet | Hidetaka Hamasaki Yu Kawashima Hiroki Adachi Sumie Moriyama Hisayuki Katsuyama Akahito Sako Hidekatsu Yanai |
| author_sort | Hidetaka Hamasaki |
| collection | DOAJ |
| description | Background. Age-related loss of muscle mass (sarcopenia) increases the incidence of obesity in the elderly by reducing physical activity. This sarcopenic obesity may become self-perpetuating, increasing the risks for metabolic syndrome, disability, and mortality. We investigated the associations of two sarcopenic indices, the ratio of lower extremity muscle mass to body weight (L/W ratio) and the ratio of lower extremity muscle mass to upper extremity muscle mass (L/U ratio), with metabolic parameters related to obesity in patients with type 2 diabetes and obesity.Methods. Of 148 inpatients with type 2 diabetes treated between October 2013 and April 2014, we recruited 26 with obesity but no physical disability. Daily physical activity was measured by a triaxial accelerometer during a period of hospitalization, and which was also evaluated by our previously reported non-exercise activity thermogenesis questionnaire. We measured body composition by bioelectrical impedance and investigated the correlations of L/W and L/U ratios with body weight, body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), visceral fat area, subcutaneous fat area, serum lipid profile, and daily physical activity.Results. The L/W ratio was significantly and negatively correlated with BMI, WC, WHR, body fat mass, body fat percentage, subcutaneous fat area, and serum free fatty acid concentration, was positively correlated with daily physical activity: the locomotive non-exercise activity thermogenesis score, but was not correlated with visceral fat area. The L/U ratio was significantly and positively correlated with serum high-density lipoprotein cholesterol.Conclusions. High L/W and L/U ratios, indicative of relatively preserved lower extremity muscle mass, were predictive of improved metabolic parameters related to obesity. Preserved muscle fitness in obesity, especially of the lower extremities, may prevent sarcopenic obesity and lower associated risks for metabolic syndrome and early mortality. |
| first_indexed | 2024-03-09T07:58:22Z |
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| last_indexed | 2024-03-09T07:58:22Z |
| publishDate | 2015-05-01 |
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| spelling | doaj.art-3f8a7c5fc85649c9ab423542f351cf992023-12-03T00:50:55ZengPeerJ Inc.PeerJ2167-83592015-05-013e94210.7717/peerj.942942Associations between lower extremity muscle mass and metabolic parameters related to obesity in Japanese obese patients with type 2 diabetesHidetaka Hamasaki0Yu Kawashima1Hiroki Adachi2Sumie Moriyama3Hisayuki Katsuyama4Akahito Sako5Hidekatsu Yanai6Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba, JapanDepartment of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba, JapanDepartment of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba, JapanDepartment of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba, JapanDepartment of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba, JapanDepartment of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba, JapanDepartment of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba, JapanBackground. Age-related loss of muscle mass (sarcopenia) increases the incidence of obesity in the elderly by reducing physical activity. This sarcopenic obesity may become self-perpetuating, increasing the risks for metabolic syndrome, disability, and mortality. We investigated the associations of two sarcopenic indices, the ratio of lower extremity muscle mass to body weight (L/W ratio) and the ratio of lower extremity muscle mass to upper extremity muscle mass (L/U ratio), with metabolic parameters related to obesity in patients with type 2 diabetes and obesity.Methods. Of 148 inpatients with type 2 diabetes treated between October 2013 and April 2014, we recruited 26 with obesity but no physical disability. Daily physical activity was measured by a triaxial accelerometer during a period of hospitalization, and which was also evaluated by our previously reported non-exercise activity thermogenesis questionnaire. We measured body composition by bioelectrical impedance and investigated the correlations of L/W and L/U ratios with body weight, body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), visceral fat area, subcutaneous fat area, serum lipid profile, and daily physical activity.Results. The L/W ratio was significantly and negatively correlated with BMI, WC, WHR, body fat mass, body fat percentage, subcutaneous fat area, and serum free fatty acid concentration, was positively correlated with daily physical activity: the locomotive non-exercise activity thermogenesis score, but was not correlated with visceral fat area. The L/U ratio was significantly and positively correlated with serum high-density lipoprotein cholesterol.Conclusions. High L/W and L/U ratios, indicative of relatively preserved lower extremity muscle mass, were predictive of improved metabolic parameters related to obesity. Preserved muscle fitness in obesity, especially of the lower extremities, may prevent sarcopenic obesity and lower associated risks for metabolic syndrome and early mortality.https://peerj.com/articles/942.pdfObesityResistance trainingMuscle massSarcopeniaType 2 diabetes |
| spellingShingle | Hidetaka Hamasaki Yu Kawashima Hiroki Adachi Sumie Moriyama Hisayuki Katsuyama Akahito Sako Hidekatsu Yanai Associations between lower extremity muscle mass and metabolic parameters related to obesity in Japanese obese patients with type 2 diabetes PeerJ Obesity Resistance training Muscle mass Sarcopenia Type 2 diabetes |
| title | Associations between lower extremity muscle mass and metabolic parameters related to obesity in Japanese obese patients with type 2 diabetes |
| title_full | Associations between lower extremity muscle mass and metabolic parameters related to obesity in Japanese obese patients with type 2 diabetes |
| title_fullStr | Associations between lower extremity muscle mass and metabolic parameters related to obesity in Japanese obese patients with type 2 diabetes |
| title_full_unstemmed | Associations between lower extremity muscle mass and metabolic parameters related to obesity in Japanese obese patients with type 2 diabetes |
| title_short | Associations between lower extremity muscle mass and metabolic parameters related to obesity in Japanese obese patients with type 2 diabetes |
| title_sort | associations between lower extremity muscle mass and metabolic parameters related to obesity in japanese obese patients with type 2 diabetes |
| topic | Obesity Resistance training Muscle mass Sarcopenia Type 2 diabetes |
| url | https://peerj.com/articles/942.pdf |
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