Genetic variation in Japanese Holstein cattle for EBL development
Abstract Background Infection with bovine leukemia virus (BLV), the causative agent for enzootic bovine leukosis (EBL), is increasing in dairy farms of Japan. The tendency of tumor development following BLV infection in certain cow families and bull lines has previously been described. We therefore...
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | BMC Veterinary Research |
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| Online Access: | http://link.springer.com/article/10.1186/s12917-020-02625-8 |
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| author | Yasuko Inagaki Tomoko Kobayashi Yoshihito Suda Kazuya Kusama Kazuhiko Imakawa |
| author_facet | Yasuko Inagaki Tomoko Kobayashi Yoshihito Suda Kazuya Kusama Kazuhiko Imakawa |
| author_sort | Yasuko Inagaki |
| collection | DOAJ |
| description | Abstract Background Infection with bovine leukemia virus (BLV), the causative agent for enzootic bovine leukosis (EBL), is increasing in dairy farms of Japan. The tendency of tumor development following BLV infection in certain cow families and bull lines has previously been described. We therefore hypothesized the existence of a genetic component which differentiates cattle susceptibility to the disease. Results We analyzed routinely collected large-scale data including postmortem inspection data, which were combined with pedigree information and epidemiological data of BLV infection. A total of 6,022 postmortem inspection records of Holstein cattle, raised on 226 farms served by a regional abattoir over 10 years from 2004 to 2015, were analyzed for associations between sire information and EBL development. We then identified statistically the relative susceptibility to EBL development for the progeny of specific sires and paternal grandsires (PGSs). The heritability of EBL development was calculated as 0.19. Similarly, proviral loads (PVLs) of progeny from identified sires and PGSs were analyzed, but no significant differences were found. Conclusions These observations suggest that because EBL development in our Holstein population is, at least in part, influenced by genetic factors independent of PVL levels, genetic improvement for lower incidence of EBL development in cattle notwithstanding BLV infection is possible. |
| first_indexed | 2024-12-13T15:45:50Z |
| format | Article |
| id | doaj.art-3f8aa02cf31a4669a1dd1c3d6d5e7e6f |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-12-13T15:45:50Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-3f8aa02cf31a4669a1dd1c3d6d5e7e6f2022-12-21T23:39:42ZengBMCBMC Veterinary Research1746-61482020-10-011611810.1186/s12917-020-02625-8Genetic variation in Japanese Holstein cattle for EBL developmentYasuko Inagaki0Tomoko Kobayashi1Yoshihito Suda2Kazuya Kusama3Kazuhiko Imakawa4Laboratory of Animal Health, Department of Animal Science, Faculty of Agriculture, Tokyo University of AgricultureLaboratory of Animal Health, Department of Animal Science, Faculty of Agriculture, Tokyo University of AgricultureDepartment of Food, Agriculture and Environment, Miyagi UniversityDepartment of Endocrine Pharmacology, Tokyo University of Pharmacy and Life SciencesLaboratory of Molecular Reproduction, Research Institute of Agriculture, Tokai UniversityAbstract Background Infection with bovine leukemia virus (BLV), the causative agent for enzootic bovine leukosis (EBL), is increasing in dairy farms of Japan. The tendency of tumor development following BLV infection in certain cow families and bull lines has previously been described. We therefore hypothesized the existence of a genetic component which differentiates cattle susceptibility to the disease. Results We analyzed routinely collected large-scale data including postmortem inspection data, which were combined with pedigree information and epidemiological data of BLV infection. A total of 6,022 postmortem inspection records of Holstein cattle, raised on 226 farms served by a regional abattoir over 10 years from 2004 to 2015, were analyzed for associations between sire information and EBL development. We then identified statistically the relative susceptibility to EBL development for the progeny of specific sires and paternal grandsires (PGSs). The heritability of EBL development was calculated as 0.19. Similarly, proviral loads (PVLs) of progeny from identified sires and PGSs were analyzed, but no significant differences were found. Conclusions These observations suggest that because EBL development in our Holstein population is, at least in part, influenced by genetic factors independent of PVL levels, genetic improvement for lower incidence of EBL development in cattle notwithstanding BLV infection is possible.http://link.springer.com/article/10.1186/s12917-020-02625-8Bovine leukemia virusEnzootic bovine leukosisHolstein cattleheritability |
| spellingShingle | Yasuko Inagaki Tomoko Kobayashi Yoshihito Suda Kazuya Kusama Kazuhiko Imakawa Genetic variation in Japanese Holstein cattle for EBL development BMC Veterinary Research Bovine leukemia virus Enzootic bovine leukosis Holstein cattle heritability |
| title | Genetic variation in Japanese Holstein cattle for EBL development |
| title_full | Genetic variation in Japanese Holstein cattle for EBL development |
| title_fullStr | Genetic variation in Japanese Holstein cattle for EBL development |
| title_full_unstemmed | Genetic variation in Japanese Holstein cattle for EBL development |
| title_short | Genetic variation in Japanese Holstein cattle for EBL development |
| title_sort | genetic variation in japanese holstein cattle for ebl development |
| topic | Bovine leukemia virus Enzootic bovine leukosis Holstein cattle heritability |
| url | http://link.springer.com/article/10.1186/s12917-020-02625-8 |
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