Effects of One-Shot Hyaluronic Acid Injection in Lifelong Premature Ejaculation: A Pilot Study
The therapeutic management of premature lifelong ejaculation (PE) ranges from behavioral therapy to pharmacological and surgical treatments. Hyaluronic Acid (HA) injection into the glans penis is a non-surgical procedure, intended to reduce glans hypersensitivity, improving the intravaginal ejaculat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Endocrines |
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| Online Access: | https://www.mdpi.com/2673-396X/3/3/44 |
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| author | Anna Perri Danilo Lofaro Stefano Iuliano Sabrina Bossio Vittoria Rago Rocco Damiano Luigi Di Luigi Sandro La Vignera Nicola Mondaini Antonio Aversa |
| author_facet | Anna Perri Danilo Lofaro Stefano Iuliano Sabrina Bossio Vittoria Rago Rocco Damiano Luigi Di Luigi Sandro La Vignera Nicola Mondaini Antonio Aversa |
| author_sort | Anna Perri |
| collection | DOAJ |
| description | The therapeutic management of premature lifelong ejaculation (PE) ranges from behavioral therapy to pharmacological and surgical treatments. Hyaluronic Acid (HA) injection into the glans penis is a non-surgical procedure, intended to reduce glans hypersensitivity, improving the intravaginal ejaculation latency time (IELT). HA injection can be performed through different techniques that, although safe and effective, rarely can cause local complications. In this pilot uncontrolled study, we tested the effectiveness of a new technique based on a single HA injection into the frenulum of the glans, to improve IELT in a sample of patients affected by PE. We observed a significant increase of the IELT after one (median 73.3, IQR 66.2–79.9 s) and two months (66.2, 63.1–73.9) that gradually decreased at three months, remaining still significantly higher than at baseline (34.8, 30.9–37.4). PEDT and IIEF questionnaires significantly improved compared to baseline in the first two months of follow-up (<i>p</i> < 0.001). In conclusion, the preliminary results emerging from this pilot uncontrolled study, highlight the effectiveness of this one-shot HA injection approach, although a larger sample and longer follow-up time are needed to standardize the procedure. |
| first_indexed | 2024-03-10T00:09:57Z |
| format | Article |
| id | doaj.art-3f8bf735ca9c4e5e9aa13f79306c52d7 |
| institution | Directory Open Access Journal |
| issn | 2673-396X |
| language | English |
| last_indexed | 2024-03-10T00:09:57Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Endocrines |
| spelling | doaj.art-3f8bf735ca9c4e5e9aa13f79306c52d72023-11-23T16:00:36ZengMDPI AGEndocrines2673-396X2022-09-013353854410.3390/endocrines3030044Effects of One-Shot Hyaluronic Acid Injection in Lifelong Premature Ejaculation: A Pilot StudyAnna Perri0Danilo Lofaro1Stefano Iuliano2Sabrina Bossio3Vittoria Rago4Rocco Damiano5Luigi Di Luigi6Sandro La Vignera7Nicola Mondaini8Antonio Aversa9Department of Experimental and Clinical Medicine, University of Catanzaro “Magna Græcia”, 88100 Catanzaro, ItalydeHealth Lab, Department of Mechanical Energetic and Management Engineering, University of Calabria, 87036 Rende, ItalyDepartment of Experimental and Clinical Medicine, University of Catanzaro “Magna Græcia”, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, University of Catanzaro “Magna Græcia”, 88100 Catanzaro, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, ItalyDepartment of Experimental and Clinical Medicine, University of Catanzaro “Magna Græcia”, 88100 Catanzaro, ItalyDepartment of Movement, Human and Health Sciences, University of Rome “Foro Italico”, 00135 Rome, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95124 Catania, ItalyDepartment of Experimental and Clinical Medicine, University of Catanzaro “Magna Græcia”, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, University of Catanzaro “Magna Græcia”, 88100 Catanzaro, ItalyThe therapeutic management of premature lifelong ejaculation (PE) ranges from behavioral therapy to pharmacological and surgical treatments. Hyaluronic Acid (HA) injection into the glans penis is a non-surgical procedure, intended to reduce glans hypersensitivity, improving the intravaginal ejaculation latency time (IELT). HA injection can be performed through different techniques that, although safe and effective, rarely can cause local complications. In this pilot uncontrolled study, we tested the effectiveness of a new technique based on a single HA injection into the frenulum of the glans, to improve IELT in a sample of patients affected by PE. We observed a significant increase of the IELT after one (median 73.3, IQR 66.2–79.9 s) and two months (66.2, 63.1–73.9) that gradually decreased at three months, remaining still significantly higher than at baseline (34.8, 30.9–37.4). PEDT and IIEF questionnaires significantly improved compared to baseline in the first two months of follow-up (<i>p</i> < 0.001). In conclusion, the preliminary results emerging from this pilot uncontrolled study, highlight the effectiveness of this one-shot HA injection approach, although a larger sample and longer follow-up time are needed to standardize the procedure.https://www.mdpi.com/2673-396X/3/3/44premature lifelong ejaculation (PE)intravaginal ejaculation latency time (IELT)hyaluronic acid (HA)HA injection |
| spellingShingle | Anna Perri Danilo Lofaro Stefano Iuliano Sabrina Bossio Vittoria Rago Rocco Damiano Luigi Di Luigi Sandro La Vignera Nicola Mondaini Antonio Aversa Effects of One-Shot Hyaluronic Acid Injection in Lifelong Premature Ejaculation: A Pilot Study Endocrines premature lifelong ejaculation (PE) intravaginal ejaculation latency time (IELT) hyaluronic acid (HA) HA injection |
| title | Effects of One-Shot Hyaluronic Acid Injection in Lifelong Premature Ejaculation: A Pilot Study |
| title_full | Effects of One-Shot Hyaluronic Acid Injection in Lifelong Premature Ejaculation: A Pilot Study |
| title_fullStr | Effects of One-Shot Hyaluronic Acid Injection in Lifelong Premature Ejaculation: A Pilot Study |
| title_full_unstemmed | Effects of One-Shot Hyaluronic Acid Injection in Lifelong Premature Ejaculation: A Pilot Study |
| title_short | Effects of One-Shot Hyaluronic Acid Injection in Lifelong Premature Ejaculation: A Pilot Study |
| title_sort | effects of one shot hyaluronic acid injection in lifelong premature ejaculation a pilot study |
| topic | premature lifelong ejaculation (PE) intravaginal ejaculation latency time (IELT) hyaluronic acid (HA) HA injection |
| url | https://www.mdpi.com/2673-396X/3/3/44 |
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