Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome
Abstract Background We and others have observed that young girls predisposed to polycystic ovary syndrome (PCOS) display defective insulin sensitivity, beta-cell function and non-esterified fatty acids (NEFA) suppressibility during early pubertal years, compared to controls. Our objective is to asse...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-07-01
|
| Series: | Reproductive Biology and Endocrinology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12958-017-0275-0 |
| _version_ | 1818333366187982848 |
|---|---|
| author | Soren Harnois-Leblanc Andréanne Trottier Samuel Leblanc Marie-Claude Battista David H. Geller Jean-Patrice Baillargeon |
| author_facet | Soren Harnois-Leblanc Andréanne Trottier Samuel Leblanc Marie-Claude Battista David H. Geller Jean-Patrice Baillargeon |
| author_sort | Soren Harnois-Leblanc |
| collection | DOAJ |
| description | Abstract Background We and others have observed that young girls predisposed to polycystic ovary syndrome (PCOS) display defective insulin sensitivity, beta-cell function and non-esterified fatty acids (NEFA) suppressibility during early pubertal years, compared to controls. Our objective is to assess whether these differences in glucose and NEFA metabolisms persist after 5 years in late/post-puberty. Methods We conducted a prospective cohort study between 2007 and 2015 with 4–6 years of follow-up in an academic institution research center. We compared 8 daughters and sisters of PCOS women (PCOSr) to 8 age-matched girls unrelated to PCOS (±1.5 years). Girls were assessed initially at 8–14 years old and re-assessed after a median follow-up of 5.4 years, at 13–21 years old. Our main measures were a frequently sampled intravenous glucose tolerance test (FSivGTT)-derived insulin sensitivity (IS) and beta-cell function (disposition index, DIFSivGTT); and indices of NEFA suppression during FSivGTT (logn-linear slope of NEFA and T50 of NEFA suppression). Results At follow-up, both PCOSr and controls had similar results: IS = 3.2 vs 3.4 (p = 0.88), DIFSivGTT = 1926 vs 1380 (p = 0.44), logn-linear slope = −0.032 vs −0.032 (p = 0.88) and T50NEFA = 18.1 vs 20.8 min (p = 0.57). IS, DIFSivGTT and NEFA suppressibility were stable in PCOSr after 5 years, but decreased significantly in controls (all p < 0.05). Conclusions Impaired metabolism observed during early puberty in girls predisposed to PCOS remains stable after 5 years whereas control girls deteriorated their metabolic parameters. Therefore, both groups become comparable in late/post-puberty. Early puberty may thus represent a window during which metabolic alterations are transiently apparent in girls at risk of PCOS. |
| first_indexed | 2024-12-13T13:50:29Z |
| format | Article |
| id | doaj.art-3f8d2bb6b5404aae9ccb23899cceb007 |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-12-13T13:50:29Z |
| publishDate | 2017-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-3f8d2bb6b5404aae9ccb23899cceb0072022-12-21T23:43:12ZengBMCReproductive Biology and Endocrinology1477-78272017-07-011511910.1186/s12958-017-0275-0Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndromeSoren Harnois-Leblanc0Andréanne Trottier1Samuel Leblanc2Marie-Claude Battista3David H. Geller4Jean-Patrice Baillargeon5Division of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Université de SherbrookeDivision of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Université de SherbrookeDivision of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Université de SherbrookeResearch Center, Centre Hospitalier Universitaire de SherbrookeDepartment of Pediatrics, Cedars-Sinai Medical CenterDivision of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Université de SherbrookeAbstract Background We and others have observed that young girls predisposed to polycystic ovary syndrome (PCOS) display defective insulin sensitivity, beta-cell function and non-esterified fatty acids (NEFA) suppressibility during early pubertal years, compared to controls. Our objective is to assess whether these differences in glucose and NEFA metabolisms persist after 5 years in late/post-puberty. Methods We conducted a prospective cohort study between 2007 and 2015 with 4–6 years of follow-up in an academic institution research center. We compared 8 daughters and sisters of PCOS women (PCOSr) to 8 age-matched girls unrelated to PCOS (±1.5 years). Girls were assessed initially at 8–14 years old and re-assessed after a median follow-up of 5.4 years, at 13–21 years old. Our main measures were a frequently sampled intravenous glucose tolerance test (FSivGTT)-derived insulin sensitivity (IS) and beta-cell function (disposition index, DIFSivGTT); and indices of NEFA suppression during FSivGTT (logn-linear slope of NEFA and T50 of NEFA suppression). Results At follow-up, both PCOSr and controls had similar results: IS = 3.2 vs 3.4 (p = 0.88), DIFSivGTT = 1926 vs 1380 (p = 0.44), logn-linear slope = −0.032 vs −0.032 (p = 0.88) and T50NEFA = 18.1 vs 20.8 min (p = 0.57). IS, DIFSivGTT and NEFA suppressibility were stable in PCOSr after 5 years, but decreased significantly in controls (all p < 0.05). Conclusions Impaired metabolism observed during early puberty in girls predisposed to PCOS remains stable after 5 years whereas control girls deteriorated their metabolic parameters. Therefore, both groups become comparable in late/post-puberty. Early puberty may thus represent a window during which metabolic alterations are transiently apparent in girls at risk of PCOS.http://link.springer.com/article/10.1186/s12958-017-0275-0Polycystic ovary syndromeDaughtersPubertyInsulin sensitivityNon-esterified fatty acidsGlucose homeostasis |
| spellingShingle | Soren Harnois-Leblanc Andréanne Trottier Samuel Leblanc Marie-Claude Battista David H. Geller Jean-Patrice Baillargeon Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome Reproductive Biology and Endocrinology Polycystic ovary syndrome Daughters Puberty Insulin sensitivity Non-esterified fatty acids Glucose homeostasis |
| title | Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome |
| title_full | Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome |
| title_fullStr | Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome |
| title_full_unstemmed | Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome |
| title_short | Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome |
| title_sort | evolution of metabolic alterations 5 years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome |
| topic | Polycystic ovary syndrome Daughters Puberty Insulin sensitivity Non-esterified fatty acids Glucose homeostasis |
| url | http://link.springer.com/article/10.1186/s12958-017-0275-0 |
| work_keys_str_mv | AT sorenharnoisleblanc evolutionofmetabolicalterations5yearsafterearlypubertyinacohortofgirlspredisposedtopolycysticovarysyndrome AT andreannetrottier evolutionofmetabolicalterations5yearsafterearlypubertyinacohortofgirlspredisposedtopolycysticovarysyndrome AT samuelleblanc evolutionofmetabolicalterations5yearsafterearlypubertyinacohortofgirlspredisposedtopolycysticovarysyndrome AT marieclaudebattista evolutionofmetabolicalterations5yearsafterearlypubertyinacohortofgirlspredisposedtopolycysticovarysyndrome AT davidhgeller evolutionofmetabolicalterations5yearsafterearlypubertyinacohortofgirlspredisposedtopolycysticovarysyndrome AT jeanpatricebaillargeon evolutionofmetabolicalterations5yearsafterearlypubertyinacohortofgirlspredisposedtopolycysticovarysyndrome |