Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering
The application of scaffolding materials is believed to hold enormous potential for tissue regeneration. Despite the widespread application and rapid advance of several tissue-engineered scaffolds such as natural and synthetic polymer-based scaffolds, they have limited repair capacity due to the dif...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2022-04-01
|
| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X2100431X |
| _version_ | 1797203221554397184 |
|---|---|
| author | Xuewei Zhang Xi Chen Hua Hong Rubei Hu Jiashang Liu Changsheng Liu |
| author_facet | Xuewei Zhang Xi Chen Hua Hong Rubei Hu Jiashang Liu Changsheng Liu |
| author_sort | Xuewei Zhang |
| collection | DOAJ |
| description | The application of scaffolding materials is believed to hold enormous potential for tissue regeneration. Despite the widespread application and rapid advance of several tissue-engineered scaffolds such as natural and synthetic polymer-based scaffolds, they have limited repair capacity due to the difficulties in overcoming the immunogenicity, simulating in-vivo microenvironment, and performing mechanical or biochemical properties similar to native organs/tissues. Fortunately, the emergence of decellularized extracellular matrix (dECM) scaffolds provides an attractive way to overcome these hurdles, which mimic an optimal non-immune environment with native three-dimensional structures and various bioactive components. The consequent cell-seeded construct based on dECM scaffolds, especially stem cell-recellularized construct, is considered an ideal choice for regenerating functional organs/tissues. Herein, we review recent developments in dECM scaffolds and put forward perspectives accordingly, with particular focus on the concept and fabrication of decellularized scaffolds, as well as the application of decellularized scaffolds and their combinations with stem cells (recellularized scaffolds) in tissue engineering, including skin, bone, nerve, heart, along with lung, liver and kidney. |
| first_indexed | 2024-04-24T08:15:53Z |
| format | Article |
| id | doaj.art-3f8d4260b79741bea3bee33f28d3e4ed |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:15:53Z |
| publishDate | 2022-04-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-3f8d4260b79741bea3bee33f28d3e4ed2024-04-17T03:46:43ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2022-04-01101531Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineeringXuewei Zhang0Xi Chen1Hua Hong2Rubei Hu3Jiashang Liu4Changsheng Liu5Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomaterials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, PR ChinaCorresponding author.; Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomaterials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, PR ChinaKey Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomaterials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, PR ChinaKey Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomaterials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, PR ChinaKey Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomaterials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, PR ChinaCorresponding author.; Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomaterials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, PR ChinaThe application of scaffolding materials is believed to hold enormous potential for tissue regeneration. Despite the widespread application and rapid advance of several tissue-engineered scaffolds such as natural and synthetic polymer-based scaffolds, they have limited repair capacity due to the difficulties in overcoming the immunogenicity, simulating in-vivo microenvironment, and performing mechanical or biochemical properties similar to native organs/tissues. Fortunately, the emergence of decellularized extracellular matrix (dECM) scaffolds provides an attractive way to overcome these hurdles, which mimic an optimal non-immune environment with native three-dimensional structures and various bioactive components. The consequent cell-seeded construct based on dECM scaffolds, especially stem cell-recellularized construct, is considered an ideal choice for regenerating functional organs/tissues. Herein, we review recent developments in dECM scaffolds and put forward perspectives accordingly, with particular focus on the concept and fabrication of decellularized scaffolds, as well as the application of decellularized scaffolds and their combinations with stem cells (recellularized scaffolds) in tissue engineering, including skin, bone, nerve, heart, along with lung, liver and kidney.http://www.sciencedirect.com/science/article/pii/S2452199X2100431XDecellularizationECM3D scaffoldsTissue regenerationRecellularization |
| spellingShingle | Xuewei Zhang Xi Chen Hua Hong Rubei Hu Jiashang Liu Changsheng Liu Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering Bioactive Materials Decellularization ECM 3D scaffolds Tissue regeneration Recellularization |
| title | Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering |
| title_full | Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering |
| title_fullStr | Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering |
| title_full_unstemmed | Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering |
| title_short | Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering |
| title_sort | decellularized extracellular matrix scaffolds recent trends and emerging strategies in tissue engineering |
| topic | Decellularization ECM 3D scaffolds Tissue regeneration Recellularization |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X2100431X |
| work_keys_str_mv | AT xueweizhang decellularizedextracellularmatrixscaffoldsrecenttrendsandemergingstrategiesintissueengineering AT xichen decellularizedextracellularmatrixscaffoldsrecenttrendsandemergingstrategiesintissueengineering AT huahong decellularizedextracellularmatrixscaffoldsrecenttrendsandemergingstrategiesintissueengineering AT rubeihu decellularizedextracellularmatrixscaffoldsrecenttrendsandemergingstrategiesintissueengineering AT jiashangliu decellularizedextracellularmatrixscaffoldsrecenttrendsandemergingstrategiesintissueengineering AT changshengliu decellularizedextracellularmatrixscaffoldsrecenttrendsandemergingstrategiesintissueengineering |