The Biological Effects of Novel Nutraceuticals with Curcuminoids and Other Plant-Derived Immunomodulators and Pre-Probiotics
An effective and well-balanced immune system is pivotal for maintaining health. Diet and nutrition can affect the functioning of numerous immune parameters, with direct repercussions on homeostasis. Since our immune functions are indispensable in defending the body against pathogens and thus play a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/5/666 |
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| author | Adina Elena Răducanu Bianca-Maria Tihăuan Ioana Cristina Marinaș Oana Teodora Ciupercă Carmen Elena Țebrencu Elena Ionescu Tatiana Onisei |
| author_facet | Adina Elena Răducanu Bianca-Maria Tihăuan Ioana Cristina Marinaș Oana Teodora Ciupercă Carmen Elena Țebrencu Elena Ionescu Tatiana Onisei |
| author_sort | Adina Elena Răducanu |
| collection | DOAJ |
| description | An effective and well-balanced immune system is pivotal for maintaining health. Diet and nutrition can affect the functioning of numerous immune parameters, with direct repercussions on homeostasis. Since our immune functions are indispensable in defending the body against pathogens and thus play a vital role in maintaining health, modulating immune response may well serve as the basis for the development of plant-based functional foods and novel nutraceuticals. This concept is currently utilized in attempts to prevent or mitigate inflammatory reactions via the development of targeted food products or active ingredients since an extended number of phytoconstituents (such as curcuminoids) are associated with beneficial effects on immunity. Immunomodulatory plant-based dietary supplements are considered effective in improving immune functions and reducing the incidence of immunological disorders or imbalances. Therefore, the main focus of this study was to evidence the beneficial biological effects such as antioxidant and antimicrobial, as well as nutritional status, biocompatibility and cell proliferation capacity and immunomodulation of two novel nutraceuticals. The first nutraceutic was based on curcuminoids and other actives from <i>Trigonella foenum- graecum</i> (seeds), <i>Chelidonium majus</i> L. (aerial parts), <i>Taraxacum officinale</i> L. (roots), vitamins (C, D3, A, E) and minerals (zinc) whereas the second one was made of probiotics such as <i>Lactobacillus acidophilus</i> and <i>Bifidobacterium animalis subsp. Lactis</i> combined with actives from <i>Helianthus tuberosus</i> (tubers) and <i>Psyllium</i>/<i>Plantago ovata</i> (husk) as herbal prebiotics. |
| first_indexed | 2024-03-10T11:40:18Z |
| format | Article |
| id | doaj.art-3f8dcac4775644b2be813d172f0e0ff5 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T11:40:18Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-3f8dcac4775644b2be813d172f0e0ff52023-11-21T18:30:03ZengMDPI AGPharmaceutics1999-49232021-05-0113566610.3390/pharmaceutics13050666The Biological Effects of Novel Nutraceuticals with Curcuminoids and Other Plant-Derived Immunomodulators and Pre-ProbioticsAdina Elena Răducanu0Bianca-Maria Tihăuan1Ioana Cristina Marinaș2Oana Teodora Ciupercă3Carmen Elena Țebrencu4Elena Ionescu5Tatiana Onisei6Research and Development Department, The National Institute for Research and Development in Food Bioresources, Str. Dinu Vintilă, No.6, 021102 Bucharest, RomaniaResearch and Development Department, The National Institute for Research and Development in Food Bioresources, Str. Dinu Vintilă, No.6, 021102 Bucharest, RomaniaResearch Institute of the University of Bucharest—ICUB, 91–95 Spl. Independentei, 50567 Bucharest, RomaniaFaculty of Chemical Engineering and Environmental Protection “Cristofor Simionescu”, “Gheorghe Asachi” Technical University of Iași, 73, Prof. Dr. Docent D. Mangeron Street, 700050 Iași, RomaniaResearch and Processing Centre for Medicinal Plants “PLANTAVOREL” S.A., 46, Cuza Voda Street, 610019 Piatra Neamţ, RomaniaResearch and Processing Centre for Medicinal Plants “PLANTAVOREL” S.A., 46, Cuza Voda Street, 610019 Piatra Neamţ, RomaniaResearch and Development Department, The National Institute for Research and Development in Food Bioresources, Str. Dinu Vintilă, No.6, 021102 Bucharest, RomaniaAn effective and well-balanced immune system is pivotal for maintaining health. Diet and nutrition can affect the functioning of numerous immune parameters, with direct repercussions on homeostasis. Since our immune functions are indispensable in defending the body against pathogens and thus play a vital role in maintaining health, modulating immune response may well serve as the basis for the development of plant-based functional foods and novel nutraceuticals. This concept is currently utilized in attempts to prevent or mitigate inflammatory reactions via the development of targeted food products or active ingredients since an extended number of phytoconstituents (such as curcuminoids) are associated with beneficial effects on immunity. Immunomodulatory plant-based dietary supplements are considered effective in improving immune functions and reducing the incidence of immunological disorders or imbalances. Therefore, the main focus of this study was to evidence the beneficial biological effects such as antioxidant and antimicrobial, as well as nutritional status, biocompatibility and cell proliferation capacity and immunomodulation of two novel nutraceuticals. The first nutraceutic was based on curcuminoids and other actives from <i>Trigonella foenum- graecum</i> (seeds), <i>Chelidonium majus</i> L. (aerial parts), <i>Taraxacum officinale</i> L. (roots), vitamins (C, D3, A, E) and minerals (zinc) whereas the second one was made of probiotics such as <i>Lactobacillus acidophilus</i> and <i>Bifidobacterium animalis subsp. Lactis</i> combined with actives from <i>Helianthus tuberosus</i> (tubers) and <i>Psyllium</i>/<i>Plantago ovata</i> (husk) as herbal prebiotics.https://www.mdpi.com/1999-4923/13/5/666novel nutraceuticalsplant-based immunomodulatorspre-probioticsantimicrobialcytotoxic |
| spellingShingle | Adina Elena Răducanu Bianca-Maria Tihăuan Ioana Cristina Marinaș Oana Teodora Ciupercă Carmen Elena Țebrencu Elena Ionescu Tatiana Onisei The Biological Effects of Novel Nutraceuticals with Curcuminoids and Other Plant-Derived Immunomodulators and Pre-Probiotics Pharmaceutics novel nutraceuticals plant-based immunomodulators pre-probiotics antimicrobial cytotoxic |
| title | The Biological Effects of Novel Nutraceuticals with Curcuminoids and Other Plant-Derived Immunomodulators and Pre-Probiotics |
| title_full | The Biological Effects of Novel Nutraceuticals with Curcuminoids and Other Plant-Derived Immunomodulators and Pre-Probiotics |
| title_fullStr | The Biological Effects of Novel Nutraceuticals with Curcuminoids and Other Plant-Derived Immunomodulators and Pre-Probiotics |
| title_full_unstemmed | The Biological Effects of Novel Nutraceuticals with Curcuminoids and Other Plant-Derived Immunomodulators and Pre-Probiotics |
| title_short | The Biological Effects of Novel Nutraceuticals with Curcuminoids and Other Plant-Derived Immunomodulators and Pre-Probiotics |
| title_sort | biological effects of novel nutraceuticals with curcuminoids and other plant derived immunomodulators and pre probiotics |
| topic | novel nutraceuticals plant-based immunomodulators pre-probiotics antimicrobial cytotoxic |
| url | https://www.mdpi.com/1999-4923/13/5/666 |
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