High Levels of Heavy Metal(loid)s Related to Biliary Hyperplasia in Hedgehogs (<i>Erinaceus europaeus</i>)
Heavy metal(loid) pollution of ecosystems is a current One Health problem. The liver is one of the most affected organs in cases of acute or chronic exposure to abnormal amounts of these substances, inducing histopathologic lesions. In order to assess the influence of heavy metal(loids), forty-five...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/13/8/1359 |
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| author | Catarina Jota Baptista Fernanda Seixas José M. Gonzalo-Orden Carla Patinha Pedro Pato Eduardo Ferreira da Silva María Casero Erica Brazio Ricardo Brandão Daniela Costa Teresa Letra Mateus Paula A. Oliveira |
| author_facet | Catarina Jota Baptista Fernanda Seixas José M. Gonzalo-Orden Carla Patinha Pedro Pato Eduardo Ferreira da Silva María Casero Erica Brazio Ricardo Brandão Daniela Costa Teresa Letra Mateus Paula A. Oliveira |
| author_sort | Catarina Jota Baptista |
| collection | DOAJ |
| description | Heavy metal(loid) pollution of ecosystems is a current One Health problem. The liver is one of the most affected organs in cases of acute or chronic exposure to abnormal amounts of these substances, inducing histopathologic lesions. In order to assess the influence of heavy metal(loids), forty-five European hedgehogs (<i>Erinaceus europaeus</i>) were submitted to necropsy, and liver samples were collected for a routine histopathology exam and metal(loid)s determination (As, Cd, Co, Cr, Cu and Pb) by ICP-MS. Age was estimated during the necropsy exam. Biliary hyperplasia was the most frequent lesion observed (16/45; 35.56%). No statistically significant associations were found between biliary hyperplasia and age or sex. Metal(loid)s’ concentrations were higher in animals with biliary hyperplasia (except for As). There was a statistically significant difference for both Cd and Co. For As, Cd and Co, cubs and juveniles animals showed significantly lower concentrations than elder individuals. Only for Pb were significant differences found between females and males. As described in the literature, exposure to metal(loid)s may be a cause of biliary hyperplasia, although further research (including the use of biochemical methods) is needed to support these results. To the authors’ knowledge, this is the first report of this association in hedgehogs. |
| first_indexed | 2024-03-11T05:18:45Z |
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| id | doaj.art-3f8dd85bb26c46bb8f6a7dea9ed6deef |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-11T05:18:45Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-3f8dd85bb26c46bb8f6a7dea9ed6deef2023-11-17T18:00:42ZengMDPI AGAnimals2076-26152023-04-01138135910.3390/ani13081359High Levels of Heavy Metal(loid)s Related to Biliary Hyperplasia in Hedgehogs (<i>Erinaceus europaeus</i>)Catarina Jota Baptista0Fernanda Seixas1José M. Gonzalo-Orden2Carla Patinha3Pedro Pato4Eduardo Ferreira da Silva5María Casero6Erica Brazio7Ricardo Brandão8Daniela Costa9Teresa Letra Mateus10Paula A. Oliveira11Departamento de Ciências Veterinárias, Escola de Ciências Agrárias e Veterinárias (ECAV), Universidade de Trás-os-Montes e Alto Douro, UTAD, 5000-801 Vila Real, PortugalDepartamento de Ciências Veterinárias, Escola de Ciências Agrárias e Veterinárias (ECAV), Universidade de Trás-os-Montes e Alto Douro, UTAD, 5000-801 Vila Real, PortugalInstituto de Biomedicina (IBIOMED), Universidad de León, 24071 León, SpainGeoBioTec, Departamento de Geociências, Universidade de Aveiro, 3810-193 Aveiro, PortugalGeoBioTec, Departamento de Geociências, Universidade de Aveiro, 3810-193 Aveiro, PortugalGeoBioTec, Departamento de Geociências, Universidade de Aveiro, 3810-193 Aveiro, PortugalRIAS-ALDEIA—Wildlife Rehabilitation and Research Centre, Parque Natural da Ria Formosa, 8700-194 Olhão, PortugalCentro de Recuperação dos Animais Silvestres de Lisboa (LxCRAS), Parque Florestal de Monsanto, 1500-068 Lisboa, PortugalCERVAS-ALDEIA—Centro de Ecologia, Recuperação e Vigilância de Animais Selvagens, 6290-520 Gouveia, PortugalCERVAS-ALDEIA—Centro de Ecologia, Recuperação e Vigilância de Animais Selvagens, 6290-520 Gouveia, PortugalCentro de Ciência Animal e Veterinária (CECAV), AL4AnimalS, UTAD, 5000-801 Vila Real, PortugalDepartamento de Ciências Veterinárias, Escola de Ciências Agrárias e Veterinárias (ECAV), Universidade de Trás-os-Montes e Alto Douro, UTAD, 5000-801 Vila Real, PortugalHeavy metal(loid) pollution of ecosystems is a current One Health problem. The liver is one of the most affected organs in cases of acute or chronic exposure to abnormal amounts of these substances, inducing histopathologic lesions. In order to assess the influence of heavy metal(loids), forty-five European hedgehogs (<i>Erinaceus europaeus</i>) were submitted to necropsy, and liver samples were collected for a routine histopathology exam and metal(loid)s determination (As, Cd, Co, Cr, Cu and Pb) by ICP-MS. Age was estimated during the necropsy exam. Biliary hyperplasia was the most frequent lesion observed (16/45; 35.56%). No statistically significant associations were found between biliary hyperplasia and age or sex. Metal(loid)s’ concentrations were higher in animals with biliary hyperplasia (except for As). There was a statistically significant difference for both Cd and Co. For As, Cd and Co, cubs and juveniles animals showed significantly lower concentrations than elder individuals. Only for Pb were significant differences found between females and males. As described in the literature, exposure to metal(loid)s may be a cause of biliary hyperplasia, although further research (including the use of biochemical methods) is needed to support these results. To the authors’ knowledge, this is the first report of this association in hedgehogs.https://www.mdpi.com/2076-2615/13/8/1359metalbiliary hyperplasiahepatotoxicityhistopathologywildlifeOne Health |
| spellingShingle | Catarina Jota Baptista Fernanda Seixas José M. Gonzalo-Orden Carla Patinha Pedro Pato Eduardo Ferreira da Silva María Casero Erica Brazio Ricardo Brandão Daniela Costa Teresa Letra Mateus Paula A. Oliveira High Levels of Heavy Metal(loid)s Related to Biliary Hyperplasia in Hedgehogs (<i>Erinaceus europaeus</i>) Animals metal biliary hyperplasia hepatotoxicity histopathology wildlife One Health |
| title | High Levels of Heavy Metal(loid)s Related to Biliary Hyperplasia in Hedgehogs (<i>Erinaceus europaeus</i>) |
| title_full | High Levels of Heavy Metal(loid)s Related to Biliary Hyperplasia in Hedgehogs (<i>Erinaceus europaeus</i>) |
| title_fullStr | High Levels of Heavy Metal(loid)s Related to Biliary Hyperplasia in Hedgehogs (<i>Erinaceus europaeus</i>) |
| title_full_unstemmed | High Levels of Heavy Metal(loid)s Related to Biliary Hyperplasia in Hedgehogs (<i>Erinaceus europaeus</i>) |
| title_short | High Levels of Heavy Metal(loid)s Related to Biliary Hyperplasia in Hedgehogs (<i>Erinaceus europaeus</i>) |
| title_sort | high levels of heavy metal loid s related to biliary hyperplasia in hedgehogs i erinaceus europaeus i |
| topic | metal biliary hyperplasia hepatotoxicity histopathology wildlife One Health |
| url | https://www.mdpi.com/2076-2615/13/8/1359 |
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