Oligomerization of Hsp70: Current Perspectives on Regulation and Function

Oligomerization of Hsp70: Current Perspectives on Regulation and Function

The Hsp70 molecular chaperone in conjunction with Hsp90 and a suite of helper co-chaperones are required for the folding and subsequent refolding of a large proportion of the proteome. These proteins are critical for cell viability and play major roles in diseases of proteostasis which include neuro...

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Bibliographic Details
Main Authors: Jade E. Takakuwa, Nitika, Laura E. Knighton, Andrew W. Truman
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
Hsp70
molecular chaperones
dimerization
oligomerization
proteostasis
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2019.00081/full

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