Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective
The absence of ‘shovel-ready’ anti-coronavirus drugs during vaccine development has exceedingly worsened the SARS-CoV-2 pandemic. Furthermore, new vaccine-resistant variants and coronavirus outbreaks may occur in the near future, and we must be ready to face this possibility. However, efficient anti...
Main Authors: | Mona Seifert, Subhas C Bera, Pauline van Nies, Robert N Kirchdoerfer, Ashleigh Shannon, Thi-Tuyet-Nhung Le, Xiangzhi Meng, Hongjie Xia, James M Wood, Lawrence D Harris, Flavia S Papini, Jamie J Arnold, Steven Almo, Tyler L Grove, Pei-Yong Shi, Yan Xiang, Bruno Canard, Martin Depken, Craig E Cameron, David Dulin |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-10-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/70968 |
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