A novel strategy to generate immunocytokines with activity-on-demand using small molecule inhibitors

A novel strategy to generate immunocytokines with activity-on-demand using small molecule inhibitors

Abstract Cytokine-based therapeutics have been shown to mediate objective responses in certain tumor entities but suffer from insufficient selectivity, causing limiting toxicity which prevents dose escalation to therapeutically active regimens. The antibody-based delivery of cytokines significantly...

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Bibliographic Details
Main Authors: Giulia Rotta, Ettore Gilardoni, Domenico Ravazza, Jacqueline Mock, Frauke Seehusen, Abdullah Elsayed, Emanuele Puca, Roberto De Luca, Christian Pellegrino, Thomas Look, Tobias Weiss, Markus G Manz, Cornelia Halin, Dario Neri, Sheila Dakhel Plaza
Format: Article
Language:English
Published: Springer Nature 2024-03-01
Series:EMBO Molecular Medicine
Subjects:
Cancer Immunotherapy
Tumor Targeting
Antibody-Cytokine Fusions
Tolerability
Small Molecule Inhibitors
Online Access:https://doi.org/10.1038/s44321-024-00034-0

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