CASTLEMAN DISEASE VARIANT OF POEMS SYNDROME. A CASE REPORT
Introduction: POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein, Skin changes) syndrome is a rare multisystem disorder. Castleman disease is an atypical lymphoproliferative disorder of unknown cause, which can be associated to POEMS. Clinical Case: This is the case of a 37-y...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Spanish |
| Published: |
Universidad Ricardo Palma
2019-10-01
|
| Series: | Revista de la Facultad de Medicina Humana |
| Subjects: | |
| Online Access: | http://revistas.urp.edu.pe/index.php/RFMH/article/view/2145 |
| _version_ | 1818759301430247424 |
|---|---|
| author | Pedro Paolo Sotelo Fanny Elizabeth Ramírez Calderón María Del Pilar Quiñones Avila |
| author_facet | Pedro Paolo Sotelo Fanny Elizabeth Ramírez Calderón María Del Pilar Quiñones Avila |
| author_sort | Pedro Paolo Sotelo |
| collection | DOAJ |
| description | Introduction: POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein, Skin changes) syndrome is a rare multisystem disorder. Castleman disease is an atypical lymphoproliferative disorder of unknown cause, which can be associated to POEMS.
Clinical Case: This is the case of a 37-year-old patient with 2-year history of numbness and weakness in lower limbs associated to multiple adenopathy, skin hyperpigmentation and hypertrichosis. Electromyography showed active chronic sensory-motor polyneuropathy of axonal type; and serum electrophoresis showed a monoclonal band of A Immunoglobulin lambda type. Submaxillary lymph node biopsy was consistent with Castleman Disease.
Conclusion: This report highlights the fact that Castleman Disease is frequent among patients with POEMS syndrome, constituting a significant variant, and should always be ruled out. Furthermore, plasmapheresis could be a useful alternative among patients with severe neurological symptoms. |
| first_indexed | 2024-12-18T06:40:33Z |
| format | Article |
| id | doaj.art-3f93578c68ca429083fa40a59e3a91c6 |
| institution | Directory Open Access Journal |
| issn | 1814-5469 2308-0531 |
| language | Spanish |
| last_indexed | 2024-12-18T06:40:33Z |
| publishDate | 2019-10-01 |
| publisher | Universidad Ricardo Palma |
| record_format | Article |
| series | Revista de la Facultad de Medicina Humana |
| spelling | doaj.art-3f93578c68ca429083fa40a59e3a91c62022-12-21T21:17:38ZspaUniversidad Ricardo PalmaRevista de la Facultad de Medicina Humana1814-54692308-05312019-10-0119412012510.25176/RFMH.v19i4.2145CASTLEMAN DISEASE VARIANT OF POEMS SYNDROME. A CASE REPORTPedro Paolo SoteloFanny Elizabeth Ramírez Calderón0María Del Pilar Quiñones Avilahttps://orcid.org/0000-0003-3992-983XIntroduction: POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein, Skin changes) syndrome is a rare multisystem disorder. Castleman disease is an atypical lymphoproliferative disorder of unknown cause, which can be associated to POEMS. Clinical Case: This is the case of a 37-year-old patient with 2-year history of numbness and weakness in lower limbs associated to multiple adenopathy, skin hyperpigmentation and hypertrichosis. Electromyography showed active chronic sensory-motor polyneuropathy of axonal type; and serum electrophoresis showed a monoclonal band of A Immunoglobulin lambda type. Submaxillary lymph node biopsy was consistent with Castleman Disease. Conclusion: This report highlights the fact that Castleman Disease is frequent among patients with POEMS syndrome, constituting a significant variant, and should always be ruled out. Furthermore, plasmapheresis could be a useful alternative among patients with severe neurological symptoms.http://revistas.urp.edu.pe/index.php/RFMH/article/view/2145POEMS syndromeCastleman's diseasePlasmapheresis |
| spellingShingle | Pedro Paolo Sotelo Fanny Elizabeth Ramírez Calderón María Del Pilar Quiñones Avila CASTLEMAN DISEASE VARIANT OF POEMS SYNDROME. A CASE REPORT Revista de la Facultad de Medicina Humana POEMS syndrome Castleman's disease Plasmapheresis |
| title | CASTLEMAN DISEASE VARIANT OF POEMS SYNDROME. A CASE REPORT |
| title_full | CASTLEMAN DISEASE VARIANT OF POEMS SYNDROME. A CASE REPORT |
| title_fullStr | CASTLEMAN DISEASE VARIANT OF POEMS SYNDROME. A CASE REPORT |
| title_full_unstemmed | CASTLEMAN DISEASE VARIANT OF POEMS SYNDROME. A CASE REPORT |
| title_short | CASTLEMAN DISEASE VARIANT OF POEMS SYNDROME. A CASE REPORT |
| title_sort | castleman disease variant of poems syndrome a case report |
| topic | POEMS syndrome Castleman's disease Plasmapheresis |
| url | http://revistas.urp.edu.pe/index.php/RFMH/article/view/2145 |
| work_keys_str_mv | AT pedropaolosotelo castlemandiseasevariantofpoemssyndromeacasereport AT fannyelizabethramirezcalderon castlemandiseasevariantofpoemssyndromeacasereport AT mariadelpilarquinonesavila castlemandiseasevariantofpoemssyndromeacasereport |