The Lumen of Human Intestinal Organoids Poses Greater Stress to Bacteria Compared to the Germ-Free Mouse Intestine: <named-content content-type="genus-species">Escherichia coli</named-content> Deficient in RpoS as a Colonization Probe

The Lumen of Human Intestinal Organoids Poses Greater Stress to Bacteria Compared to the Germ-Free Mouse Intestine: <named-content content-type="genus-species">Escherichia coli</named-content> Deficient in RpoS as a Colonization Probe

ABSTRACT Pluripotent stem-cell-derived human intestinal organoids (HIOs) are three-dimensional, multicellular structures that model a naive intestinal epithelium in an in vitro system. Several published reports have investigated the use of HIOs to study host-microbe interactions. We recently demonst...

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Bibliographic Details
Main Authors: Madeline R. Barron, Roberto J. Cieza, David R. Hill, Sha Huang, Veda K. Yadagiri, Jason R. Spence, Vincent B. Young
Format: Article
Language:English
Published: American Society for Microbiology 2020-12-01
Series:mSphere
Subjects:
RpoS
colonization
intestine
organoid
stress
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00777-20

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