Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions
Implantable biomaterials evoke foreign body responses in the central nervous system. The authors compare hydrogel-based biomaterials to identify cellular interactions and molecular mechanisms that drive different types of foreign body responses that have different effects on biomaterial function.
Main Authors: | Timothy M. OʼShea, Alexander L. Wollenberg, Jae H. Kim, Yan Ao, Timothy J. Deming, Michael V. Sofroniew |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2020-12-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-19906-3 |
Similar Items
-
Investigating Immunomodulatory Biomaterials for Preventing the Foreign Body Response
by: Alexia Kim, et al.
Published: (2023-12-01) -
Modulating, instead of suppressing, foreign body responses for biomaterials design
by: Zhencheng Liao, et al.
Published: (2021-01-01) -
Intracochlear fibrosis and the foreign body response to cochlear implant biomaterials
by: Megan J. Foggia, et al.
Published: (2019-12-01) -
Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response
by: Doloff, Joshua C, et al.
Published: (2024) -
Mechanisms of Foreign Body Giant Cell Formation in Response to Implantable Biomaterials
by: Farshid Eslami-Kaliji, et al.
Published: (2023-03-01)