Insidious communication amongst cancer cells
The tumor microenvironment is home to various types of cognate and non-cognate cell interactions. Here we comment on a newly discovered form of intercellular communication, which is based on endoplasmic reticulum stress signaling. Through this mechanism transmitter cancer cells impart receiver cance...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-05-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2017.1356898 |
| _version_ | 1797677203798884352 |
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| author | Jeffrey J. Rodvold Maurizio Zanetti |
| author_facet | Jeffrey J. Rodvold Maurizio Zanetti |
| author_sort | Jeffrey J. Rodvold |
| collection | DOAJ |
| description | The tumor microenvironment is home to various types of cognate and non-cognate cell interactions. Here we comment on a newly discovered form of intercellular communication, which is based on endoplasmic reticulum stress signaling. Through this mechanism transmitter cancer cells impart receiver cancer cells with resistance to secondary metabolic, pharmacologic and genotoxic stress, providing survival advantage. The implications of this finding are briefly discussed. |
| first_indexed | 2024-03-11T22:41:40Z |
| format | Article |
| id | doaj.art-3f9c4179bdf84f9b8aa1b1c096bc11ee |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:40Z |
| publishDate | 2018-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-3f9c4179bdf84f9b8aa1b1c096bc11ee2023-09-22T09:10:58ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562018-05-015310.1080/23723556.2017.13568981356898Insidious communication amongst cancer cellsJeffrey J. Rodvold0Maurizio Zanetti1University of California at San DiegoUniversity of California at San DiegoThe tumor microenvironment is home to various types of cognate and non-cognate cell interactions. Here we comment on a newly discovered form of intercellular communication, which is based on endoplasmic reticulum stress signaling. Through this mechanism transmitter cancer cells impart receiver cancer cells with resistance to secondary metabolic, pharmacologic and genotoxic stress, providing survival advantage. The implications of this finding are briefly discussed.http://dx.doi.org/10.1080/23723556.2017.1356898tumor microenvironmenter stresstumor heterogeneitychemoresistance |
| spellingShingle | Jeffrey J. Rodvold Maurizio Zanetti Insidious communication amongst cancer cells Molecular & Cellular Oncology tumor microenvironment er stress tumor heterogeneity chemoresistance |
| title | Insidious communication amongst cancer cells |
| title_full | Insidious communication amongst cancer cells |
| title_fullStr | Insidious communication amongst cancer cells |
| title_full_unstemmed | Insidious communication amongst cancer cells |
| title_short | Insidious communication amongst cancer cells |
| title_sort | insidious communication amongst cancer cells |
| topic | tumor microenvironment er stress tumor heterogeneity chemoresistance |
| url | http://dx.doi.org/10.1080/23723556.2017.1356898 |
| work_keys_str_mv | AT jeffreyjrodvold insidiouscommunicationamongstcancercells AT mauriziozanetti insidiouscommunicationamongstcancercells |