The impact of obesity towards prostate diseases
Evidence has supported obesity as a risk factor for both benign prostate hyperplasia (BPH) and prostate cancer (PCa). Obesity causes several mechanisms including increased intra-abdominal pressure, altered endocrine status, increased sympathetic nervous activity, increased inflammation process, and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-03-01
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| Series: | Prostate International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S228788821530074X |
| _version_ | 1827843348500578304 |
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| author | Dyandra Parikesit Chaidir Arief Mochtar Rainy Umbas Agus Rizal Ardy Hariandy Hamid |
| author_facet | Dyandra Parikesit Chaidir Arief Mochtar Rainy Umbas Agus Rizal Ardy Hariandy Hamid |
| author_sort | Dyandra Parikesit |
| collection | DOAJ |
| description | Evidence has supported obesity as a risk factor for both benign prostate hyperplasia (BPH) and prostate cancer (PCa). Obesity causes several mechanisms including increased intra-abdominal pressure, altered endocrine status, increased sympathetic nervous activity, increased inflammation process, and oxidative stress, all of which are favorable in the development of BPH. In PCa, there are several different mechanisms, such as decreased serum testosterone, peripheral aromatization of androgens, insulin resistance, and altered adipokine secretion caused by inflammation, which may precipitate the development of and even cause high-grade PCa. The role of obesity in prostatitis still remains unclear. A greater understanding of the pathogenesis of prostate disease and adiposity could allow the development of new therapeutic markers, prognostic indicators, and drug targets. This review was made to help better understanding of the association between central obesity and prostate diseases, such as prostatitis, BPH, and PCa. |
| first_indexed | 2024-03-12T08:24:29Z |
| format | Article |
| id | doaj.art-3f9d707fb79b458785a548faf2d94a5d |
| institution | Directory Open Access Journal |
| issn | 2287-8882 |
| language | English |
| last_indexed | 2024-03-12T08:24:29Z |
| publishDate | 2016-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Prostate International |
| spelling | doaj.art-3f9d707fb79b458785a548faf2d94a5d2023-09-02T18:12:35ZengElsevierProstate International2287-88822016-03-01411610.1016/j.prnil.2015.08.001The impact of obesity towards prostate diseasesDyandra ParikesitChaidir Arief MochtarRainy UmbasAgus Rizal Ardy Hariandy HamidEvidence has supported obesity as a risk factor for both benign prostate hyperplasia (BPH) and prostate cancer (PCa). Obesity causes several mechanisms including increased intra-abdominal pressure, altered endocrine status, increased sympathetic nervous activity, increased inflammation process, and oxidative stress, all of which are favorable in the development of BPH. In PCa, there are several different mechanisms, such as decreased serum testosterone, peripheral aromatization of androgens, insulin resistance, and altered adipokine secretion caused by inflammation, which may precipitate the development of and even cause high-grade PCa. The role of obesity in prostatitis still remains unclear. A greater understanding of the pathogenesis of prostate disease and adiposity could allow the development of new therapeutic markers, prognostic indicators, and drug targets. This review was made to help better understanding of the association between central obesity and prostate diseases, such as prostatitis, BPH, and PCa.http://www.sciencedirect.com/science/article/pii/S228788821530074XBenign Prostate HyperplasiaObesityProstate CancerProstatitis |
| spellingShingle | Dyandra Parikesit Chaidir Arief Mochtar Rainy Umbas Agus Rizal Ardy Hariandy Hamid The impact of obesity towards prostate diseases Prostate International Benign Prostate Hyperplasia Obesity Prostate Cancer Prostatitis |
| title | The impact of obesity towards prostate diseases |
| title_full | The impact of obesity towards prostate diseases |
| title_fullStr | The impact of obesity towards prostate diseases |
| title_full_unstemmed | The impact of obesity towards prostate diseases |
| title_short | The impact of obesity towards prostate diseases |
| title_sort | impact of obesity towards prostate diseases |
| topic | Benign Prostate Hyperplasia Obesity Prostate Cancer Prostatitis |
| url | http://www.sciencedirect.com/science/article/pii/S228788821530074X |
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