Dopamine transporter glycosylation correlates with the vulnerability of midbrain dopaminergic cells in Parkinson's disease

Dopamine transporter glycosylation correlates with the vulnerability of midbrain dopaminergic cells in Parkinson's disease

The dopamine transporter (DAT) is a membrane glycoprotein responsible for dopamine (DA) uptake, which has been involved in the degeneration of DA cells in Parkinson's disease (PD). Given that DAT activity depends on its glycosylation status and membrane expression, and that not all midbrain DA...

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Bibliographic Details
Main Authors: Domingo Afonso-Oramas, Ignacio Cruz-Muros, Diego Álvarez de la Rosa, Pedro Abreu, Teresa Giráldez, Javier Castro-Hernández, Josmar Salas-Hernández, José L. Lanciego, Manuel Rodríguez, Tomas González-Hernández
Format: Article
Language:English
Published: Elsevier 2009-12-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Pathogenesis
Dopamine transporter
Glycosylation
Differential vulnerability
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109002435

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