Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes
Xeroderma is induced by diabetes, reducing patients’ quality of life. We aimed to clarify the roles of cutaneous water channel aquaporin-3 (AQP3) in diabetic xeroderma using type 2 diabetes model <i>db/db</i> mice. Blood glucose levels were unchanged in 5-week-old <i>db/db</i>...
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MDPI AG
2021-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/2/104 |
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| author | Nobutomo Ikarashi Nanaho Mizukami Chenchen Pei Ryogo Uchino Izumi Fujisawa Natsuko Fukuda Risako Kon Hiroyasu Sakai Junzo Kamei |
| author_facet | Nobutomo Ikarashi Nanaho Mizukami Chenchen Pei Ryogo Uchino Izumi Fujisawa Natsuko Fukuda Risako Kon Hiroyasu Sakai Junzo Kamei |
| author_sort | Nobutomo Ikarashi |
| collection | DOAJ |
| description | Xeroderma is induced by diabetes, reducing patients’ quality of life. We aimed to clarify the roles of cutaneous water channel aquaporin-3 (AQP3) in diabetic xeroderma using type 2 diabetes model <i>db/db</i> mice. Blood glucose levels were unchanged in 5-week-old <i>db/db</i> mice compared to <i>db/+</i> mice (control mice), but the pathophysiology of type 2 diabetes was confirmed in 12-week-old <i>db/db</i> mice. The dermal water content and AQP3 expression in 5-week-old <i>db/db</i> mice were almost the same as those in the control mice. On the other hand, in 12-week-old <i>db/db</i> mice, the dermal water content and AQP3 expression were significantly decreased. The addition of glucose to HaCaT cells had no effect on AQP3, but tumor necrosis factor-α (TNF-α) decreased the AQP3 expression level. Blood TNF-α levels or skin inflammation markers in the 12-week-old <i>db/db</i> mice were significantly higher than those in control mice. AQP3 levels in the skin were decreased in type 2 diabetes, and this decrease in AQP3 may be one of the causes of xeroderma. Therefore, a substance that increases AQP3 may be useful for improving xeroderma. Additionally, a decrease in skin AQP3 may be triggered by inflammation. Therefore, anti-inflammatory drugs may be effective as new therapeutic agents for diabetic xerosis. |
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| format | Article |
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| language | English |
| last_indexed | 2024-03-09T04:03:25Z |
| publishDate | 2021-01-01 |
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| series | Biomedicines |
| spelling | doaj.art-3fa2008cc889431695fa1cd9bbf342ef2023-12-03T14:10:10ZengMDPI AGBiomedicines2227-90592021-01-019210410.3390/biomedicines9020104Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 DiabetesNobutomo Ikarashi0Nanaho Mizukami1Chenchen Pei2Ryogo Uchino3Izumi Fujisawa4Natsuko Fukuda5Risako Kon6Hiroyasu Sakai7Junzo Kamei8Department of Biomolecular Pharmacology, Hoshi University, 2-4-41 Ebara, Shinagawaku, Tokyo 142-8501, JapanDepartment of Biomolecular Pharmacology, Hoshi University, 2-4-41 Ebara, Shinagawaku, Tokyo 142-8501, JapanDepartment of Biomolecular Pharmacology, Hoshi University, 2-4-41 Ebara, Shinagawaku, Tokyo 142-8501, JapanDepartment of Biomolecular Pharmacology, Hoshi University, 2-4-41 Ebara, Shinagawaku, Tokyo 142-8501, JapanDepartment of Biomolecular Pharmacology, Hoshi University, 2-4-41 Ebara, Shinagawaku, Tokyo 142-8501, JapanDepartment of Biomolecular Pharmacology, Hoshi University, 2-4-41 Ebara, Shinagawaku, Tokyo 142-8501, JapanDepartment of Biomolecular Pharmacology, Hoshi University, 2-4-41 Ebara, Shinagawaku, Tokyo 142-8501, JapanDepartment of Biomolecular Pharmacology, Hoshi University, 2-4-41 Ebara, Shinagawaku, Tokyo 142-8501, JapanDepartment of Biomolecular Pharmacology, Hoshi University, 2-4-41 Ebara, Shinagawaku, Tokyo 142-8501, JapanXeroderma is induced by diabetes, reducing patients’ quality of life. We aimed to clarify the roles of cutaneous water channel aquaporin-3 (AQP3) in diabetic xeroderma using type 2 diabetes model <i>db/db</i> mice. Blood glucose levels were unchanged in 5-week-old <i>db/db</i> mice compared to <i>db/+</i> mice (control mice), but the pathophysiology of type 2 diabetes was confirmed in 12-week-old <i>db/db</i> mice. The dermal water content and AQP3 expression in 5-week-old <i>db/db</i> mice were almost the same as those in the control mice. On the other hand, in 12-week-old <i>db/db</i> mice, the dermal water content and AQP3 expression were significantly decreased. The addition of glucose to HaCaT cells had no effect on AQP3, but tumor necrosis factor-α (TNF-α) decreased the AQP3 expression level. Blood TNF-α levels or skin inflammation markers in the 12-week-old <i>db/db</i> mice were significantly higher than those in control mice. AQP3 levels in the skin were decreased in type 2 diabetes, and this decrease in AQP3 may be one of the causes of xeroderma. Therefore, a substance that increases AQP3 may be useful for improving xeroderma. Additionally, a decrease in skin AQP3 may be triggered by inflammation. Therefore, anti-inflammatory drugs may be effective as new therapeutic agents for diabetic xerosis.https://www.mdpi.com/2227-9059/9/2/104diabetesaquaporinskinxerodermainflammationTNF-α |
| spellingShingle | Nobutomo Ikarashi Nanaho Mizukami Chenchen Pei Ryogo Uchino Izumi Fujisawa Natsuko Fukuda Risako Kon Hiroyasu Sakai Junzo Kamei Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes Biomedicines diabetes aquaporin skin xeroderma inflammation TNF-α |
| title | Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes |
| title_full | Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes |
| title_fullStr | Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes |
| title_full_unstemmed | Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes |
| title_short | Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes |
| title_sort | role of cutaneous aquaporins in the development of xeroderma in type 2 diabetes |
| topic | diabetes aquaporin skin xeroderma inflammation TNF-α |
| url | https://www.mdpi.com/2227-9059/9/2/104 |
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