CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships.
BACKGROUND:Migraine is common in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) but its treatment responses are not well described, and its relationship to stroke risk unknown. Encephalopathy is a less common presentation; it has been suggested i...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4911105?pdf=render |
| _version_ | 1828337154902720512 |
|---|---|
| author | Rhea Yan Ying Tan Hugh Stephen Markus |
| author_facet | Rhea Yan Ying Tan Hugh Stephen Markus |
| author_sort | Rhea Yan Ying Tan |
| collection | DOAJ |
| description | BACKGROUND:Migraine is common in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) but its treatment responses are not well described, and its relationship to stroke risk unknown. Encephalopathy is a less common presentation; it has been suggested it is related to migraine. We characterised migraine patterns and treatment responses in CADASIL, and examined associations between migraine and both stroke risk and encephalopathy. METHODS:300 symptomatic CADASIL patients were prospectively recruited from a national referral clinic over a nineteen year period, from 1996 to 2015. Data was collected using a standardised questionnaire. Migraine was classified according to the International Classification of Headache Disorders, 3rd edition (beta version). A cross-sectional analysis was carried out on the data collected. RESULTS:Migraine was present in 226 (75.3%), and the presenting feature in 203 (67.7%). It was usually accompanied by aura (89.8%). Patients showed variable responses to a variety of drugs for migraine. Of 24 given triptans, 45.5% had consistent or partial responses. None had complications following triptans. Thirty-three (11.0%) patients experienced encephalopathy lasting on average 8.1 ± 3.4 days. Patients with migraine with aura had higher odds of encephalopathy (OR = 5.4; 95%CI 1.6-28.4; p = 0.002). Patients with confusional aura had higher odds of encephalopathy than those with other aura types (OR = 2.5, 95%CI = 1.0-5.8, p = 0.04). There was also no increase in risk of encephalopathy with sex or age at onset of migraine. Migraineurs had a lower stroke risk than non-migraineurs (HR = 0.46, 95%CI 0.3-0.6, p = 2.1x10-6). CONCLUSIONS:Migraine with aura is a prominent feature of CADASIL. Treatment responses are similar to those seen in the general migraine population and no complications were observed with triptans. Migraine with aura was associated with increased risk of encephalopathy suggesting they may share pathophysiological mechanisms. There was no increased stroke risk associated with migraine, but risk appeared to be reduced although this finding needs confirming. |
| first_indexed | 2024-04-13T22:11:42Z |
| format | Article |
| id | doaj.art-3fa27204cbfa4b9fbbf4eac42fabdfe2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T22:11:42Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3fa27204cbfa4b9fbbf4eac42fabdfe22022-12-22T02:27:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01116e015761310.1371/journal.pone.0157613CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships.Rhea Yan Ying TanHugh Stephen MarkusBACKGROUND:Migraine is common in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) but its treatment responses are not well described, and its relationship to stroke risk unknown. Encephalopathy is a less common presentation; it has been suggested it is related to migraine. We characterised migraine patterns and treatment responses in CADASIL, and examined associations between migraine and both stroke risk and encephalopathy. METHODS:300 symptomatic CADASIL patients were prospectively recruited from a national referral clinic over a nineteen year period, from 1996 to 2015. Data was collected using a standardised questionnaire. Migraine was classified according to the International Classification of Headache Disorders, 3rd edition (beta version). A cross-sectional analysis was carried out on the data collected. RESULTS:Migraine was present in 226 (75.3%), and the presenting feature in 203 (67.7%). It was usually accompanied by aura (89.8%). Patients showed variable responses to a variety of drugs for migraine. Of 24 given triptans, 45.5% had consistent or partial responses. None had complications following triptans. Thirty-three (11.0%) patients experienced encephalopathy lasting on average 8.1 ± 3.4 days. Patients with migraine with aura had higher odds of encephalopathy (OR = 5.4; 95%CI 1.6-28.4; p = 0.002). Patients with confusional aura had higher odds of encephalopathy than those with other aura types (OR = 2.5, 95%CI = 1.0-5.8, p = 0.04). There was also no increase in risk of encephalopathy with sex or age at onset of migraine. Migraineurs had a lower stroke risk than non-migraineurs (HR = 0.46, 95%CI 0.3-0.6, p = 2.1x10-6). CONCLUSIONS:Migraine with aura is a prominent feature of CADASIL. Treatment responses are similar to those seen in the general migraine population and no complications were observed with triptans. Migraine with aura was associated with increased risk of encephalopathy suggesting they may share pathophysiological mechanisms. There was no increased stroke risk associated with migraine, but risk appeared to be reduced although this finding needs confirming.http://europepmc.org/articles/PMC4911105?pdf=render |
| spellingShingle | Rhea Yan Ying Tan Hugh Stephen Markus CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships. PLoS ONE |
| title | CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships. |
| title_full | CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships. |
| title_fullStr | CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships. |
| title_full_unstemmed | CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships. |
| title_short | CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships. |
| title_sort | cadasil migraine encephalopathy stroke and their inter relationships |
| url | http://europepmc.org/articles/PMC4911105?pdf=render |
| work_keys_str_mv | AT rheayanyingtan cadasilmigraineencephalopathystrokeandtheirinterrelationships AT hughstephenmarkus cadasilmigraineencephalopathystrokeandtheirinterrelationships |