A modification of a previous model for inflammatory tooth pain: Effects of different capsaicin and formalin concentrations and ibuprofen
BACKGROUND: This study aimed to solve the problems faced with the previous model of inflammatory tooth pain in rats. METHODS: After cutting 2 mm of the distal extremities, the polyethylene crowns were placed on the mandibular incisors. In contrast to the original model, we used flow composite inst...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Kerman University of Medical Sciences
2012-12-01
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| Series: | Journal of Oral Health and Oral Epidemiology |
| Subjects: | |
| Online Access: | http://johoe.kmu.ac.ir/index.php/johoe/article/view/14 |
| _version_ | 1818279658912743424 |
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| author | Maryam Raoof Mehdi Abbasnejad Ladan Amirkhosravi Hamed Ebrahimnejad Ramin Raoof |
| author_facet | Maryam Raoof Mehdi Abbasnejad Ladan Amirkhosravi Hamed Ebrahimnejad Ramin Raoof |
| author_sort | Maryam Raoof |
| collection | DOAJ |
| description | BACKGROUND: This study aimed to solve the problems faced with the previous model of inflammatory tooth pain in rats.
METHODS: After cutting 2 mm of the distal extremities, the polyethylene crowns were placed on the mandibular incisors. In contrast to the original model, we used flow composite instead of wire in order to maximize the retention of crowns. Different concentrations of capsaicin (10, 25 and 100 mg/ml) and formalin were administrated into the cavities under the crowns. The algesic agent-induced behaviors were evaluated.
RESULTS: The modified model had no liquid leakage. Furthermore, composite allowed the crowns to remain for a longer period of time. Capsaicin 25, 100 mg/ml and formalin applications induced significantly more painful stimulation compared with control groups (P < 0.001). These responses were significantly reduced by the administration of ibuprofen, 20 minutes prior to the capsaicin 100 mg/ml injection.
CONCLUSIONS: This model seems to be adequate for long-term pain related experiments in which fluid leakage elimination is important. |
| first_indexed | 2024-12-12T23:36:50Z |
| format | Article |
| id | doaj.art-3fa5bd1f47f24bc887ea51f9d7002175 |
| institution | Directory Open Access Journal |
| issn | 2322-1372 |
| language | English |
| last_indexed | 2024-12-12T23:36:50Z |
| publishDate | 2012-12-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Journal of Oral Health and Oral Epidemiology |
| spelling | doaj.art-3fa5bd1f47f24bc887ea51f9d70021752022-12-22T00:07:26ZengKerman University of Medical SciencesJournal of Oral Health and Oral Epidemiology2322-13722012-12-01127077917A modification of a previous model for inflammatory tooth pain: Effects of different capsaicin and formalin concentrations and ibuprofenMaryam Raoof0Mehdi Abbasnejad1Ladan Amirkhosravi2Hamed Ebrahimnejad3Ramin Raoof4Assistant Professor, Neuroscience Research Center and Department of Endodontics, Kerman University of Medical Sciences, Kerman, IranAssociate Professor, Department of Biology, School of Sciences, Shahid Bahonar University of Kerman, Kerman, IranOral and Dental Diseases Research Center, Kerman University of Medical Sciences, Kerman, IranOral and Dental Diseases Research Center, Kerman University of Medical Sciences, Kerman, IranMSc student, Department of Biology, School of Sciences, Shahid Bahonar University of Kerman, Kerman, IranBACKGROUND: This study aimed to solve the problems faced with the previous model of inflammatory tooth pain in rats. METHODS: After cutting 2 mm of the distal extremities, the polyethylene crowns were placed on the mandibular incisors. In contrast to the original model, we used flow composite instead of wire in order to maximize the retention of crowns. Different concentrations of capsaicin (10, 25 and 100 mg/ml) and formalin were administrated into the cavities under the crowns. The algesic agent-induced behaviors were evaluated. RESULTS: The modified model had no liquid leakage. Furthermore, composite allowed the crowns to remain for a longer period of time. Capsaicin 25, 100 mg/ml and formalin applications induced significantly more painful stimulation compared with control groups (P < 0.001). These responses were significantly reduced by the administration of ibuprofen, 20 minutes prior to the capsaicin 100 mg/ml injection. CONCLUSIONS: This model seems to be adequate for long-term pain related experiments in which fluid leakage elimination is important.http://johoe.kmu.ac.ir/index.php/johoe/article/view/14Odontalgia, Capsaicin, Formalin, Model, Rat |
| spellingShingle | Maryam Raoof Mehdi Abbasnejad Ladan Amirkhosravi Hamed Ebrahimnejad Ramin Raoof A modification of a previous model for inflammatory tooth pain: Effects of different capsaicin and formalin concentrations and ibuprofen Journal of Oral Health and Oral Epidemiology Odontalgia, Capsaicin, Formalin, Model, Rat |
| title | A modification of a previous model for inflammatory tooth pain: Effects of different capsaicin and formalin concentrations and ibuprofen |
| title_full | A modification of a previous model for inflammatory tooth pain: Effects of different capsaicin and formalin concentrations and ibuprofen |
| title_fullStr | A modification of a previous model for inflammatory tooth pain: Effects of different capsaicin and formalin concentrations and ibuprofen |
| title_full_unstemmed | A modification of a previous model for inflammatory tooth pain: Effects of different capsaicin and formalin concentrations and ibuprofen |
| title_short | A modification of a previous model for inflammatory tooth pain: Effects of different capsaicin and formalin concentrations and ibuprofen |
| title_sort | modification of a previous model for inflammatory tooth pain effects of different capsaicin and formalin concentrations and ibuprofen |
| topic | Odontalgia, Capsaicin, Formalin, Model, Rat |
| url | http://johoe.kmu.ac.ir/index.php/johoe/article/view/14 |
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