LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS
Purpose: LL-37 is an antimicrobial peptide which plays an important role in the innate immunity. The aim of this study was to investigate the LL-37 levels in the gingival crevicular fluid (GCF) of middle-aged and young adults who have either gingivitis or healthy periodontal tissues. Materials and...
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| Format: | Article |
| Language: | English |
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Istanbul University
2017-01-01
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| Series: | Journal of Istanbul University Faculty of Dentistry |
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| Online Access: | http://www.journals.istanbul.edu.tr/iudis/article/view/5000185508/5000179590 |
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| author | Oya TÜRKOĞLU Gülnur EMİNGİL Gülnihal EREN Harika ATMACA Necil KÜTÜKCÜLER Gül ATİLLA |
| author_facet | Oya TÜRKOĞLU Gülnur EMİNGİL Gülnihal EREN Harika ATMACA Necil KÜTÜKCÜLER Gül ATİLLA |
| author_sort | Oya TÜRKOĞLU |
| collection | DOAJ |
| description | Purpose: LL-37 is an antimicrobial peptide which plays an important role in the innate immunity. The aim of this study was to investigate the LL-37 levels in the gingival crevicular fluid (GCF) of middle-aged and young adults who have either gingivitis or healthy periodontal tissues.
Materials and Methods: Forty middle-aged adults (20 healthy controls and 20 with gingivitis) and 41 younger adults (20 healthy controls and 21 with gingivitis) were included in the present study. Probing depth, clinical attachment level, plaque index, and papilla bleeding index were recorded. LL-37 levels in the GCF were analyzed by enzyme-linked immunosorbent assay.
Results: No significant differences were observed in the GCF LL-37 levels between young healthy and middle-aged healthy subjects. Also, there were no significant differences in GCF LL-37 levels between young and middle-aged gingivitis subjects. However, gingivitis groups had significantly higher GCF LL-37 levels than healthy groups (p<0.001). Correlation analysis demonstrated no significant correlation between age and GCF LL-37 levels neither in healthy nor in gingivitis groups.
Conclusion: The levels of LL-37 in GCF increase in the presence of gingival inflammation, however, this does not vary according to subjects being young or middle-aged. |
| first_indexed | 2024-04-10T14:45:36Z |
| format | Article |
| id | doaj.art-3fa63aafb3c445609215c0eee69f5328 |
| institution | Directory Open Access Journal |
| issn | 2149-2352 2149-4592 |
| language | English |
| last_indexed | 2024-04-10T14:45:36Z |
| publishDate | 2017-01-01 |
| publisher | Istanbul University |
| record_format | Article |
| series | Journal of Istanbul University Faculty of Dentistry |
| spelling | doaj.art-3fa63aafb3c445609215c0eee69f53282023-02-15T16:07:55ZengIstanbul UniversityJournal of Istanbul University Faculty of Dentistry2149-23522149-45922017-01-01511152110.17096/jiufd.42354LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITISOya TÜRKOĞLU0Gülnur EMİNGİL1Gülnihal EREN2Harika ATMACA3Necil KÜTÜKCÜLER4Gül ATİLLA5Department of Periodontology Faculty of Dentistry Ege UniversityDepartment of Periodontology Faculty of Dentistry Ege UniversityDepartment of Periodontology Faculty of Dentistry Ege UniversityDepartment of Biology Faculty of Science and Letters, Celal Bayar UniversityDepartment of Pediatrics Faculty of Medicine Ege UniversityDepartment of Periodontology Faculty of Dentistry Ege UniversityPurpose: LL-37 is an antimicrobial peptide which plays an important role in the innate immunity. The aim of this study was to investigate the LL-37 levels in the gingival crevicular fluid (GCF) of middle-aged and young adults who have either gingivitis or healthy periodontal tissues. Materials and Methods: Forty middle-aged adults (20 healthy controls and 20 with gingivitis) and 41 younger adults (20 healthy controls and 21 with gingivitis) were included in the present study. Probing depth, clinical attachment level, plaque index, and papilla bleeding index were recorded. LL-37 levels in the GCF were analyzed by enzyme-linked immunosorbent assay. Results: No significant differences were observed in the GCF LL-37 levels between young healthy and middle-aged healthy subjects. Also, there were no significant differences in GCF LL-37 levels between young and middle-aged gingivitis subjects. However, gingivitis groups had significantly higher GCF LL-37 levels than healthy groups (p<0.001). Correlation analysis demonstrated no significant correlation between age and GCF LL-37 levels neither in healthy nor in gingivitis groups. Conclusion: The levels of LL-37 in GCF increase in the presence of gingival inflammation, however, this does not vary according to subjects being young or middle-aged.http://www.journals.istanbul.edu.tr/iudis/article/view/5000185508/5000179590Cathelicidin LL-37antimicrobial peptidegingival crevicular fluidgingivitisage |
| spellingShingle | Oya TÜRKOĞLU Gülnur EMİNGİL Gülnihal EREN Harika ATMACA Necil KÜTÜKCÜLER Gül ATİLLA LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS Journal of Istanbul University Faculty of Dentistry Cathelicidin LL-37 antimicrobial peptide gingival crevicular fluid gingivitis age |
| title | LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS |
| title_full | LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS |
| title_fullStr | LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS |
| title_full_unstemmed | LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS |
| title_short | LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS |
| title_sort | levels of ll 37 antimicrobial peptide in the gingival crevicular fluid of young and middle aged subjects with or without gingivitis |
| topic | Cathelicidin LL-37 antimicrobial peptide gingival crevicular fluid gingivitis age |
| url | http://www.journals.istanbul.edu.tr/iudis/article/view/5000185508/5000179590 |
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