Pigment epithelium-derived factor and matrix metalloproteinase-9 in liver cirrhosis
Background/Aim: The aim of this study was to assess the role of serum pigment epithelium-derived factor (PEDF) and matrix metalloproteinase-9 (MMP-9) in progression of liver cirrhosis and development of hepatocellular carcinoma (HCC). Patients and Methods: Serum levels of PEDF and MMP-9 were tested...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | The Saudi Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2016;volume=22;issue=5;spage=375;epage=379;aulast=Kozlowska |
| _version_ | 1818910710438035456 |
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| author | Joanna Kozlowska Tomasz Mikula Magdalena Suchacz Joanna Jabnonska Wojciech Stanczak Janusz Cianciara Alicja Wiercinska-Drapalo |
| author_facet | Joanna Kozlowska Tomasz Mikula Magdalena Suchacz Joanna Jabnonska Wojciech Stanczak Janusz Cianciara Alicja Wiercinska-Drapalo |
| author_sort | Joanna Kozlowska |
| collection | DOAJ |
| description | Background/Aim: The aim of this study was to assess the role of serum pigment epithelium-derived factor (PEDF) and matrix metalloproteinase-9 (MMP-9) in progression of liver cirrhosis and development of hepatocellular carcinoma (HCC). Patients and Methods: Serum levels of PEDF and MMP-9 were tested in 212 patients with liver cirrhosis and in a control group of 30 healthy volunteers. HCC was diagnosed in 45 of the 212 patients studied (21%). Results: Serum PEDF and MMP-9 were higher in the study group than that in the control group (P < 0.001). In patients with alcoholic or mixed (alcoholic and viral hepatitis-related) cirrhosis, serum PEDF was higher than that in other patients (13970.2 ± 13406.9 ng/ml vs. 8563.5 ± 9602.7 ng/ml, P = 0.008). In patients with viral hepatitis-related cirrhosis, significantly higher PEDF levels were recorded in those with HCC (13429.1 ± 12045.8) than that in patients without HCC (6660.1 ± 7927.1; P = 0.04). There was a trend for higher serum MMP-9 in patients with HCC (5778.7 ± 12426.6 vs. 1389.8 ± 1944.7 in those without HCC; P = 0.07). Significant negative correlation between serum MMP-9 and serum alpha-fetoprotein in patients with HCC was observed (r = −0.54; P = 0.04). Conclusion: Serum PEDF and MMP-9 could be auxiliary markers in diagnosis of HCC, especially in patients with low alpha-fetoprotein level. Alcohol consumption can affect serum PEDF. |
| first_indexed | 2024-12-19T22:47:08Z |
| format | Article |
| id | doaj.art-3fa6f1593d544728a49043ae41851664 |
| institution | Directory Open Access Journal |
| issn | 1319-3767 1998-4049 |
| language | English |
| last_indexed | 2024-12-19T22:47:08Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Saudi Journal of Gastroenterology |
| spelling | doaj.art-3fa6f1593d544728a49043ae418516642022-12-21T20:02:56ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492016-01-0122537537910.4103/1319-3767.191143Pigment epithelium-derived factor and matrix metalloproteinase-9 in liver cirrhosisJoanna KozlowskaTomasz MikulaMagdalena SuchaczJoanna JabnonskaWojciech StanczakJanusz CianciaraAlicja Wiercinska-DrapaloBackground/Aim: The aim of this study was to assess the role of serum pigment epithelium-derived factor (PEDF) and matrix metalloproteinase-9 (MMP-9) in progression of liver cirrhosis and development of hepatocellular carcinoma (HCC). Patients and Methods: Serum levels of PEDF and MMP-9 were tested in 212 patients with liver cirrhosis and in a control group of 30 healthy volunteers. HCC was diagnosed in 45 of the 212 patients studied (21%). Results: Serum PEDF and MMP-9 were higher in the study group than that in the control group (P < 0.001). In patients with alcoholic or mixed (alcoholic and viral hepatitis-related) cirrhosis, serum PEDF was higher than that in other patients (13970.2 ± 13406.9 ng/ml vs. 8563.5 ± 9602.7 ng/ml, P = 0.008). In patients with viral hepatitis-related cirrhosis, significantly higher PEDF levels were recorded in those with HCC (13429.1 ± 12045.8) than that in patients without HCC (6660.1 ± 7927.1; P = 0.04). There was a trend for higher serum MMP-9 in patients with HCC (5778.7 ± 12426.6 vs. 1389.8 ± 1944.7 in those without HCC; P = 0.07). Significant negative correlation between serum MMP-9 and serum alpha-fetoprotein in patients with HCC was observed (r = −0.54; P = 0.04). Conclusion: Serum PEDF and MMP-9 could be auxiliary markers in diagnosis of HCC, especially in patients with low alpha-fetoprotein level. Alcohol consumption can affect serum PEDF.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2016;volume=22;issue=5;spage=375;epage=379;aulast=KozlowskaFibrosis markershepatocellular carcinomaliver cirrhosis |
| spellingShingle | Joanna Kozlowska Tomasz Mikula Magdalena Suchacz Joanna Jabnonska Wojciech Stanczak Janusz Cianciara Alicja Wiercinska-Drapalo Pigment epithelium-derived factor and matrix metalloproteinase-9 in liver cirrhosis The Saudi Journal of Gastroenterology Fibrosis markers hepatocellular carcinoma liver cirrhosis |
| title | Pigment epithelium-derived factor and matrix metalloproteinase-9 in liver cirrhosis |
| title_full | Pigment epithelium-derived factor and matrix metalloproteinase-9 in liver cirrhosis |
| title_fullStr | Pigment epithelium-derived factor and matrix metalloproteinase-9 in liver cirrhosis |
| title_full_unstemmed | Pigment epithelium-derived factor and matrix metalloproteinase-9 in liver cirrhosis |
| title_short | Pigment epithelium-derived factor and matrix metalloproteinase-9 in liver cirrhosis |
| title_sort | pigment epithelium derived factor and matrix metalloproteinase 9 in liver cirrhosis |
| topic | Fibrosis markers hepatocellular carcinoma liver cirrhosis |
| url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2016;volume=22;issue=5;spage=375;epage=379;aulast=Kozlowska |
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