Establishment and validation of computational model for MT1-MMP dependent ECM degradation and intervention strategies.

Establishment and validation of computational model for MT1-MMP dependent ECM degradation and intervention strategies.

MT1-MMP is a potent invasion-promoting membrane protease employed by aggressive cancer cells. MT1-MMP localizes preferentially at membrane protrusions called invadopodia where it plays a central role in degradation of the surrounding extracellular matrix (ECM). Previous reports suggested a role for...

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Bibliographic Details
Main Authors: Daisuke Hoshino, Naohiko Koshikawa, Takashi Suzuki, Vito Quaranta, Alissa M Weaver, Motoharu Seiki, Kazuhisa Ichikawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3325185?pdf=render

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