Evaluation of Prothrombin Time in Acute Acetaminophen Overdose treated by N-acetylcysteine
Background: Acetaminophen (N-Acetyl-p aminophenol; APAP) is one of the most common types of analgesics. It is also the most common xneobitic reported to poison centers. This study investigates if therapeutic doses of NAC can falsely increase coagulation tests, prothrombin time (PT) and bleeding time...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2016-02-01
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| Series: | Asia Pacific Journal of Medical Toxicology |
| Subjects: | |
| Online Access: | http://apjmt.mums.ac.ir/article_7352_11b27c9c2774f607c70cc673ee70bc12.pdf |
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| author | Babak Mostafazadeh Soheila Vaghefi Mohammadali Emamhadi Latif Gachkar |
| author_facet | Babak Mostafazadeh Soheila Vaghefi Mohammadali Emamhadi Latif Gachkar |
| author_sort | Babak Mostafazadeh |
| collection | DOAJ |
| description | Background: Acetaminophen (N-Acetyl-p aminophenol; APAP) is one of the most common types of analgesics. It is also the most common xneobitic reported to poison centers. This study investigates if therapeutic doses of NAC can falsely increase coagulation tests, prothrombin time (PT) and bleeding time (BT). Methods: Thirty-six APAP poisoned patients whose acetaminophen serum concentration were in toxic zone in the Rummak-Matheiw graph were treated by NAC according to standard intravenous 21 hours protocol. Prothrombin time (PT) and bleeding time (BT) in all cases were measured before the start of the NAC and at the 8th and 16th hour of the treatment. Results: The mean age of the cases was 21.5 ± 5.12 years old. Among them, 31 cases (86%) were female. The mean dose of ingested APAP was 9.6 ±2.0 grams (7.8 – 16.1 g). Mean of SLA was 196.0±37.7. The means of BT were nor significantly different at all evolution times (2.6±0.64, 2.6±0.62 and 2.6± 0.6. The means of PT rose at 16th hour of NAC treatment in as compared 8th hour (16.1± 1.1 s 12.3±0.6 s, respectively) (P |
| first_indexed | 2024-12-14T04:14:13Z |
| format | Article |
| id | doaj.art-3fa8176ebffb4df9bbdd11d8ac31f008 |
| institution | Directory Open Access Journal |
| issn | 2322-2611 2322-4320 |
| language | English |
| last_indexed | 2024-12-14T04:14:13Z |
| publishDate | 2016-02-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Asia Pacific Journal of Medical Toxicology |
| spelling | doaj.art-3fa8176ebffb4df9bbdd11d8ac31f0082022-12-21T23:17:35ZengMashhad University of Medical SciencesAsia Pacific Journal of Medical Toxicology2322-26112322-43202016-02-0152464810.22038/apjmt.2016.73527352Evaluation of Prothrombin Time in Acute Acetaminophen Overdose treated by N-acetylcysteineBabak Mostafazadeh0Soheila Vaghefi1Mohammadali Emamhadi2Latif Gachkar3Associate Professor, Department of Forensic Medicine and Toxicology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Clinical Specialist in Forensic Medicine and Toxicology, Mofid Educational Hospital, Department of Forensic Medicine and Toxicology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranAssociate Professor of Forensic Medicine and Toxicology, Department of Forensic Medicine and Toxicology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranProfessor of Infectious Diseases, School of Medicine, Department of Infectious Diseases, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranBackground: Acetaminophen (N-Acetyl-p aminophenol; APAP) is one of the most common types of analgesics. It is also the most common xneobitic reported to poison centers. This study investigates if therapeutic doses of NAC can falsely increase coagulation tests, prothrombin time (PT) and bleeding time (BT). Methods: Thirty-six APAP poisoned patients whose acetaminophen serum concentration were in toxic zone in the Rummak-Matheiw graph were treated by NAC according to standard intravenous 21 hours protocol. Prothrombin time (PT) and bleeding time (BT) in all cases were measured before the start of the NAC and at the 8th and 16th hour of the treatment. Results: The mean age of the cases was 21.5 ± 5.12 years old. Among them, 31 cases (86%) were female. The mean dose of ingested APAP was 9.6 ±2.0 grams (7.8 – 16.1 g). Mean of SLA was 196.0±37.7. The means of BT were nor significantly different at all evolution times (2.6±0.64, 2.6±0.62 and 2.6± 0.6. The means of PT rose at 16th hour of NAC treatment in as compared 8th hour (16.1± 1.1 s 12.3±0.6 s, respectively) (Phttp://apjmt.mums.ac.ir/article_7352_11b27c9c2774f607c70cc673ee70bc12.pdfAcetaminophen PoisoningN-acetylcysteineBleeding TimeProthrombin Time |
| spellingShingle | Babak Mostafazadeh Soheila Vaghefi Mohammadali Emamhadi Latif Gachkar Evaluation of Prothrombin Time in Acute Acetaminophen Overdose treated by N-acetylcysteine Asia Pacific Journal of Medical Toxicology Acetaminophen Poisoning N-acetylcysteine Bleeding Time Prothrombin Time |
| title | Evaluation of Prothrombin Time in Acute Acetaminophen Overdose treated by N-acetylcysteine |
| title_full | Evaluation of Prothrombin Time in Acute Acetaminophen Overdose treated by N-acetylcysteine |
| title_fullStr | Evaluation of Prothrombin Time in Acute Acetaminophen Overdose treated by N-acetylcysteine |
| title_full_unstemmed | Evaluation of Prothrombin Time in Acute Acetaminophen Overdose treated by N-acetylcysteine |
| title_short | Evaluation of Prothrombin Time in Acute Acetaminophen Overdose treated by N-acetylcysteine |
| title_sort | evaluation of prothrombin time in acute acetaminophen overdose treated by n acetylcysteine |
| topic | Acetaminophen Poisoning N-acetylcysteine Bleeding Time Prothrombin Time |
| url | http://apjmt.mums.ac.ir/article_7352_11b27c9c2774f607c70cc673ee70bc12.pdf |
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